Patents by Inventor Scot R. Weinberger
Scot R. Weinberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150057949Abstract: Methods and systems for improved chemical event detection from back scattering interferometry fringe data provide sensitive detection of a chemical event by more selectively analyzing fringe shift data.Type: ApplicationFiled: March 15, 2013Publication date: February 26, 2015Inventors: Scot R. Weinberger, William E. Rich, Stephen Dotson, Kirk C. Odencrantz, Fei Shen, Richard Isaacs
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Publication number: 20120176627Abstract: This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The device can do so under conditions in which ambient temperature changes from 0.1° C. to 5° C. over 5 minutes.Type: ApplicationFiled: January 10, 2012Publication date: July 12, 2012Applicants: Vanderbilt University, Molecular Sensing, Inc.Inventors: Scot R. Weinberger, Bruce J. Richardson, Darryl L. Bornhop
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Patent number: 8120777Abstract: This invention provides an interferometric detection device configured to maintain a temperature of a sensing area to within 20 m° C. of a first target temperature and to maintain a temperature of the medium within 500 m° C. of a second target temperature The device can do so under conditions in which ambient temperature changes from 0.1° C. to 5° C. over 5 minutes.Type: GrantFiled: December 9, 2008Date of Patent: February 21, 2012Assignees: Molecular Sensing, Inc., Vanderbilt UniversityInventors: Scot R. Weinberger, Bruce J. Richardson, Darryl J. Bornhop
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Publication number: 20090185190Abstract: This invention provides an interferometer for detecting analyte in a microfluidic chip. The device maintains a stable temperature at the chip with variation of no more than 5 microdegrees C. and/or no more than 20 microdegrees C. in the medium through which the optical train travels from a source of coherent light to the chip when ambient temperature changes up to 5 degrees centigrade over five minutes. The device comprises thermally isolated compartments that hinder heat transfer from one part of the instrument to another and temperature regulators that regulate temperature of the chip and the optical train compartment as a function of temperatures at the chip, in the compartment, and ambient. The invention also provides a microfluidic system that can deliver 1 microliter of sample to a sensing area with loss in analyte concentration of less than 5%. The device has an adaptor that mates with a micropipette tip and short channel length and small volume to the sensing area.Type: ApplicationFiled: December 9, 2008Publication date: July 23, 2009Applicants: Molecular Sensing, Inc., Vanderbilt UniversityInventors: Scot R. Weinberger, Bruce J. Richardson, Darry L. Bornhop
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Patent number: 7046357Abstract: A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid path in communication with at least a discrete region of the surface, wherein the one fluid path and the discrete region together define a contained sample region on the surface. The fluidic system has a removable portion, wherein the removal of the removable portion of the fluidic system renders the discrete region directly interrogatable by a surface-based analytical tool.Type: GrantFiled: January 29, 2004Date of Patent: May 16, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Louis Hlousek
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Patent number: 6977370Abstract: Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the analyte in the presence of energy absorbing molecules at a mid-IR wavelength that is offset from an IR absorption maximum of the energy absorbing molecules.Type: GrantFiled: March 19, 2004Date of Patent: December 20, 2005Assignee: Ciphergen Biosystems, Inc.Inventor: Scot R. Weinberger
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Patent number: 6946653Abstract: Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.Type: GrantFiled: June 26, 2002Date of Patent: September 20, 2005Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Pete Tornatore
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Publication number: 20040248318Abstract: A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid path in communication with at least a discrete region of the surface, wherein the one fluid path and the discrete region together define a contained sample region on the surface. The fluidic system has a removable portion, wherein the removal of the removable portion of the fluidic system renders the discrete region directly interrogatable by a surface-based analytical tool.Type: ApplicationFiled: January 29, 2004Publication date: December 9, 2004Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Louis Hlousek
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Patent number: 6707031Abstract: A laser optical bench for use with a laser desorption/ionization mass spectrometer. The laser optical bench includes a laser for producing light, a focusing structure that receives light from the laser and focuses predominantly in a single plane, an attenuator that receives light from the focusing structure, beam steering structure for directing light from the attenuator from the target; and a final focusing element for focusing light from the beam steering structure on the target. Further focusing elements may be included for further focusing and dispersing the light beam in different planes. Additionally, photodetectors or photodiodes may be included for energy measurement and sensing a lasing event.Type: GrantFiled: May 11, 2000Date of Patent: March 16, 2004Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Raymond G. Bryan
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Publication number: 20030219731Abstract: The invention provides an analytical instrument comprising an affinity capture probe interface, a laser desorption ionization source, and a tandem mass spectrometer. Also presented are new methods for protein discovery and identification and for characterization of molecular interactions that utilize the instrument of the present invention.Type: ApplicationFiled: April 1, 2003Publication date: November 27, 2003Applicants: CIPHERGEN BIOSYSTEMS, INC., HUMAN GENOME SCIENCES, INC.Inventors: Scot R. Weinberger, Tina Morris
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Patent number: 6580071Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: GrantFiled: July 11, 2002Date of Patent: June 17, 2003Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20030098413Abstract: Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.Type: ApplicationFiled: June 26, 2002Publication date: May 29, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Pete Tornatore
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Publication number: 20030062473Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: ApplicationFiled: July 11, 2002Publication date: April 3, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20020195555Abstract: The invention provides an analytical instrument comprising an affinity capture probe interface, a laser desorption ionization source, and a tandem mass spectrometer. Also presented are new methods for protein discovery and identification and for characterization of molecular interactions that utilize the instrument of the present invention.Type: ApplicationFiled: March 8, 2002Publication date: December 26, 2002Inventors: Scot R. Weinberger, Werner Ens, Alexander Laboda, Victor Spicer, Raymond G. Bryan, Ken Standing, Pete Tornatore, James R. McNabb
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Publication number: 20020182649Abstract: Presented are novel apparatus and methods for protein characterization, identification, and sequencing using affinity capture laser desorption/ionization tandem mass spectrometry.Type: ApplicationFiled: January 31, 2002Publication date: December 5, 2002Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Huw A. Davies, Ning Tang
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Patent number: 6294790Abstract: An ion detector includes a secondary charged particle generator that generates secondary charged particles in response to primary ions that engage the secondary charged particle generator. The secondary charged particle generator has an electrostatic potential that repels the secondary charged particles toward an electro-emissive detector that generates electrons in response to primary ions and secondary charged particles that engage the electro-emissive detector The electro-emissive detector has a field that attracts the secondary charged particles. An anode is provided for detecting electrons generated by the electro-emissive detector and for generating a signal.Type: GrantFiled: September 22, 1998Date of Patent: September 25, 2001Assignee: Ciphergen Biosystems, Inc.Inventor: Scot R. Weinberger
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Patent number: 5777325Abstract: A laser desorption ionization instrument for and method of measuring the molecular weight of large organic molecules includes a time of flight mass spectrometer (TOF MS). The TOF MS instrument provides optimized optic design for both DC and TLF modes. The invention further provides dynamic resolution enhancement for a given ejection pulse, along with optimized ion ejection pulses relative to the ion optic elements. The invention also provides means for compensating for difference in total kinetic energy among ions of different mass; high resolution detection means for improved sensitivity for large molecular weight species. The invention further provides x-y-z stage for sample presentation of both standard MALDI and gel or membrane based samples.Type: GrantFiled: May 6, 1996Date of Patent: July 7, 1998Assignee: Hewlett-Packard CompanyInventors: Scot R. Weinberger, Edward P. Donlon, Yevgeny Kaplun, Tor C. Anderson, Liang Li, Larry Russon, Randy Whittal
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Patent number: 5643800Abstract: The present invention is a sample preparation system and method that can be used with all types of analyte materials, that produces homogeneously deposited crystals across a sample surface, and that lends itself to automation. In this system and method, analyte crystallization is caused by lyophilization. A homogeneous analyte/solvent mixture is placed on a sample surface. The mixture is frozen, then the solvent is sublimated through the application of a vacuum. A homogenous distribution of analyte crystals across the sample surface results.Type: GrantFiled: September 21, 1995Date of Patent: July 1, 1997Assignee: Hewlett-Packard CompanyInventors: E. Rocco Tarantino, Scot R. Weinberger
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Patent number: 5594243Abstract: A laser desorption ionization instrument for measuring the molecular weight of large organic molecules includes a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer includes a sample lock for holding, under vacuum, a plurality of samples to be analyzed. A sample may be inserted into and removed from the sample lock and into the mass spectrometer without breaking vacuum in the spectrometer. Signal processing electronics of the LDIM instrument include means for identifying quasi-molecular species of a molecule being measured. The instrument includes improvements in ion optics, microchannel plate detectors, laser irradiation of samples, and preparation of samples for measurement.Type: GrantFiled: March 4, 1993Date of Patent: January 14, 1997Assignee: Hewlett Packard CompanyInventors: Scot R. Weinberger, Robert W. Egan, Thomas W. Hoppe, deceased, Ernst Gassmann, Martin M. Schar, Klaus O. Bornsen, E. Rocco Tarantino
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Patent number: 5382793Abstract: A laser desorption ionization instrument for measuring the molecular weight of large organic molecules includes a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer includes a sample lock for holding, under vacuum, a plurality of samples to be analyzed. A sample may be inserted into and removed from the sample lock and into the mass spectrometer without breaking vacuum in the spectrometer. Signal processing electronics of the LDIM instrument include means for identifying quasi-molecular species of a molecule being measured. The instrument includes improvements in ion optics, microchannel plate detectors, laser irradiation of samples, and preparation of samples for measurement.Type: GrantFiled: March 6, 1992Date of Patent: January 17, 1995Assignee: Hewlett-Packard CompanyInventors: Scot R. Weinberger, Robert W. Egan, Thomas W. Hoppe, Ernst Gassmann, Martin M. Schar, Klaus O. Bornsen, E. Rocco Tarantino