Patents by Inventor Scott C. Weaver

Scott C. Weaver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
    Patent number: 10533186
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 14, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Attenuated Recombinant Alphaviruses Incapable of Replicating in Mosquitoes and Uses Thereof
    Publication number: 20170240919
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 24, 2017
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Alphavirus compositions and methods of use
    Patent number: 9683244
    Abstract: Embodiments are directed compositions related to Eilat virus and uses thereof.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: June 20, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Scott C. Weaver, Farooq Nasar, Rodion V. Gorchakov, Hilda Guzman, Naomi Forrester, Gustavo Palacios, Ian W. Lipkin, Robert B. Tesh
  • Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
    Patent number: 9580690
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: February 28, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Alphavirus compositions and methods of use
    Patent number: 9422529
    Abstract: Embodiments are directed compositions related to Eilat virus and uses thereof. Certain aspects are directed to the detection of non-Eilat entities using a chimeric Eilat alphavirus as a capture agent.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: August 23, 2016
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Farooq Nasar, Jesse Erasmus, Scott C. Weaver
  • Compositions and methods related to viruses of the genus
    Patent number: 9388428
    Abstract: Certain embodiments are directed to Negevirus and their polynucleotides and polypeptides.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: July 12, 2016
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Farooq Nasar, Rodion V. Gorchakov, Andrew D. Haddow, Robert B. Tesh, Hilda Guzman, Scott C. Weaver
  • Alphavirus Compositions and Methods of Use
    Publication number: 20150175975
    Abstract: Embodiments are directed compositions related to Eilat virus and uses thereof. Certain aspects are directed to the detection of non-Eilat entities using a chimeric Eilat alphavirus as a capture agent.
    Type: Application
    Filed: October 28, 2014
    Publication date: June 25, 2015
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Farooq Nasar, Jesse Erasmus, Scott C. Weaver
  • COMPOSITIONS AND METHODS RELATED TO VIRUSES OF THE GENUS NEGEVIRUS
    Publication number: 20140227765
    Abstract: Certain embodiments are directed to Negevirus and their polynucleotides and polypeptides.
    Type: Application
    Filed: November 21, 2013
    Publication date: August 14, 2014
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Farooq Nasar, Rodion V. Gorchakov, Andrew D. Haddow, Robert B. Tesh, Hilda Guzman, Scott C. Weaver
  • Chimeric sindbis-western equine encephalitis virus and uses thereof
    Patent number: 8748591
    Abstract: The present invention discloses a chimeric alphavirus comprising a Sindbis virus cDNA fragment, an Eastern equine encephalitis virus cDNA fragment, a Western equine encephalitis virus cDNA fragment or a combination thereof. The present also discloses the use of this chimeric alphavirus as vaccines and in serological and diagnostic assays.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: June 10, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Scott C. Weaver, Ilya Frolov
  • Alphavirus Compositions and Methods of Use
    Publication number: 20140056938
    Abstract: Embodiments are directed compositions related to Eilat virus and uses thereof.
    Type: Application
    Filed: June 21, 2013
    Publication date: February 27, 2014
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Scott C. Weaver, Farooq Nasar, Rodion V. Gorchakov, Hilda Guzman, Naomi Forrester, Gustavo Palacios, Ian W. Lipkin, Robert B. Tesh
  • Attenuated Recombinant Alphaviruses Incapable of Replicating in Mosquitoes and Uses Thereof
    Publication number: 20140010841
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Application
    Filed: April 3, 2013
    Publication date: January 9, 2014
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Attenuation of encephalitogenic alphavirus and uses thereof
    Patent number: 8614082
    Abstract: The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, CVEE30-68, includes two domains with distinguished functions. The integrity of both domains determines not only the intracellular distribution of CVEE, but is also essential for direct capsid function in the inhibition of transcription. The replacement of the N-terminal fragment of CVEE by its SINV-specific counterpart in VEEV TC-83 genome does not affect virus replication in vitro, but makes it less cytopathic and more attenuated in vivo.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: December 24, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Ilya V. Frolov, Elena Frolova, Scott C. Weaver
  • Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
    Patent number: 8426188
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: April 23, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Chimeric chikungunya virus and uses thereof
    Patent number: 8343506
    Abstract: The present invention discloses a chimeric Chikungunya virus comprising a heterologous alphavirus cDNA fragment and a Chikungunya virus cDNA fragment. The heterologous alphavirus may include but is not limited to Sindbis virus, Eastern equine encephalitis virus or Venezuelan equine encephalitis virus. The present invention also discloses the use of this chimeric Chikungunya virus as vaccines and in serological and diagnostic assays.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: January 1, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Ilya V. Frolov, Scott C. Weaver, Eryu Wang
  • Attenuation of Encephalitogenic Alphavirus and Uses Thereof
    Publication number: 20120100181
    Abstract: The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, CVEE30-68, includes two domains with distinguished functions. The integrity of both domains determines not only the intracellular distribution of CVEE, but is also essential for direct capsid function in the inhibition of transcription. The replacement of the N-terminal fragment of CVEE by its SINV-specific counterpart in VEEV TC-83 genome does not affect virus replication in vitro, but makes it less cytopathic and more attenuated in vivo.
    Type: Application
    Filed: October 28, 2011
    Publication date: April 26, 2012
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Ilya V. Frolov, Elena Frolova, Scott C. Weaver
  • Chimeric chikungunya virus and uses thereof
    Publication number: 20110171249
    Abstract: The present invention discloses a chimeric Chikungunya virus comprising a heterologous alphavirus cDNA fragment and a Chikungunya virus cDNA fragment. The heterologous alphavirus may include but is not limited to Sindbis virus, Eastern equine encephalitis virus or Venezuelan equine encephalitis virus. The present invention also discloses the use of this chimeric Chikungunya virus as vaccines and in serological and diagnostic assays.
    Type: Application
    Filed: April 12, 2010
    Publication date: July 14, 2011
    Inventors: Ilya V. Frolov, Scott C. Weaver, Eryu Wang
  • Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
    Publication number: 20110052634
    Abstract: The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
    Type: Application
    Filed: July 23, 2010
    Publication date: March 3, 2011
    Inventors: Scott C. Weaver, Ilya V. Frolov, Elena Frolova
  • Chimeric sindbis-eastern equine encephalitis virus and uses thereof
    Publication number: 20100247565
    Abstract: The present invention discloses a chimeric alphavirus comprising a Sindbis virus cDNA fragment and an Eastern equine encephalitis virus cDNA fragment. The present also discloses the use of this chimeric alphavirus as vaccines and in serological and diagnostic assays.
    Type: Application
    Filed: June 29, 2006
    Publication date: September 30, 2010
    Inventors: Ilya Frolov, Patricia V. Aguilar, Scott C. Weaver, Slobodan Paessler
  • Attenuation of encephalitogenic alphavirus and uses thereof
    Publication number: 20100015179
    Abstract: The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, CVEE30-68, includes two domains with distinguished functions. The integrity of both domains determines not only the intracellular distribution of CVEE, but is also essential for direct capsid function in the inhibition of transcription. The replacement of the N-terminal fragment of CVEE by its SINV-specific counterpart in VEEV TC-83 genome does not affect virus replication in vitro, but makes it less cytopathic and more attenuated in vivo.
    Type: Application
    Filed: August 15, 2008
    Publication date: January 21, 2010
    Inventors: Ilya V. Frolov, Elena Frolova, Scott C. Weaver
  • Chimeric sindbis-western equine encephalitis virus and uses thereof
    Publication number: 20080260698
    Abstract: The present invention discloses a chimeric alphavirus comprising a Sindbis virus cDNA fragment, an Eastern equine encephalitis virus cDNA fragment, a Western equine encephalitis virus cDNA fragment or a combination thereof. The present also discloses the use of this chimeric alphavirus as vaccines and in serological and diagnostic assays.
    Type: Application
    Filed: April 17, 2008
    Publication date: October 23, 2008
    Inventors: Scott C. Weaver, Ilya Frolov