Patents by Inventor Scott Deamond

Scott Deamond has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use
    Patent number: 7262177
    Abstract: A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and P represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner, wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: August 28, 2007
    Assignee: Cell Works Therapeutics, Inc.
    Inventors: Paul O. P. Ts'O, Robert Duff, Scott Deamond
  • Ligands to enhance cellular uptake of biomolecules
    Publication number: 20060183886
    Abstract: The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payload” to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway.
    Type: Application
    Filed: October 21, 2005
    Publication date: August 17, 2006
    Inventors: Paul Tso, Robert Duff, Yuanzhong Zhou, Scott Deamond, Clinton Roby
  • Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use
    Publication number: 20050250679
    Abstract: A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and P represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner, wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
    Type: Application
    Filed: June 13, 2005
    Publication date: November 10, 2005
    Inventors: Paul Ts'O, Robert Duff, Scott Deamond
  • Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
    Patent number: 6906182
    Abstract: A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, and P represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner, wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 14, 2005
    Assignees: Cell Works Therapeutics, Inc., Johns Hopkins University
    Inventors: Paul O. P. Ts'o, Robert Duff, Scott Deamond
  • Ligands to enhance cellular uptake of biomolecules
    Publication number: 20030119724
    Abstract: The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or “payload” to a hepatocyte intracellularly via a receptor-mediated, ligand-directed pathway.
    Type: Application
    Filed: June 22, 2001
    Publication date: June 26, 2003
    Inventors: Paul O.P. Ts`o, Robert Duff, Yuanzhong Zhou, Scott Deamond, Clinton Roby
  • Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
    Publication number: 20030032584
    Abstract: A conjugate of formula A-L-P, in which:
    Type: Application
    Filed: November 30, 2001
    Publication date: February 13, 2003
    Applicant: Cell Works Inc.
    Inventors: Paul O.P. Ts'o, Robert Duff, Scott Deamond