Patents by Inventor Scott E. Denmark
Scott E. Denmark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11774454Abstract: The present disclosure provides non-invasive methods for determining the gender of an embryo during in vitro embryo culture.Type: GrantFiled: May 12, 2023Date of Patent: October 3, 2023Assignee: The Board of Trustees of the University of IllinoisInventors: Marcello Rubessa, Matthew B. Wheeler, Andrea Ambrosi, Scott E. Denmark, Dianelys Gonzalez-Pena
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Publication number: 20230303612Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.Type: ApplicationFiled: May 18, 2023Publication date: September 28, 2023Inventors: Jonas Verhoeven, Guido Alfons F. Verniest, Johannes Wilhelmus John F. Thuring, Tongfei Wu, Vineet Pande, Lieven Meerpoel, Dirk Brehmer, Weimei Sun, Scott E. Denmark
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Patent number: 11702441Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.Type: GrantFiled: June 10, 2021Date of Patent: July 18, 2023Assignee: Janssen Pharmaceutica NVInventors: Jonas Verhoeven, Guido Alfons F. Verniest, Johannes Wilhelmus John F. Thuring, Tongfei Wu, Vineet Pande, Lieven Meerpoel, Dirk Brehmer, Weimei Sun, Scott E. Denmark
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Patent number: 11664093Abstract: Catalyst design in asymmetric reaction development has traditionally been driven by empiricism, wherein experimentalists attempt to qualitatively recognize structural patterns to improve selectivity. Machine learning algorithms and chemoinformatics can potentially accelerate this process by recognizing otherwise inscrutable patterns in large datasets. Herein we report a computationally guided workflow for chiral catalyst selection using chemoinformatics at every stage of development. Robust molecular descriptors that are agnostic to the catalyst scaffold allow for selection of a universal training set on the basis of steric and electronic properties. This set can be used to train machine learning methods to make highly accurate predictive models over a broad range of selectivity space. Using support vector machines and deep feed-forward neural networks, we demonstrate accurate predictive modeling in the chiral phosphoric acid-catalyzed thiol addition to N-acylimines.Type: GrantFiled: August 26, 2019Date of Patent: May 30, 2023Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Scott E. Denmark, Andrew F. Zahrt, Jeremy J. Henle, Brennan T. Rose, Yang Wang, William T. Darrow
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Patent number: 11427887Abstract: Disclosed herein is a method for extracting precious metals from supported catalysts. The precious metal in one embodiment is rhodium. The supported catalyst may be from equipment, such as a used catalytic converter. The method is carried out at low temperature, and does not require harsh conditions, such as the use of a strong acid. The method involves contacting the catalytic material with a polar molecule and a reactive gas.Type: GrantFiled: November 26, 2018Date of Patent: August 30, 2022Assignee: The Board of Trustees of the University of IllinoisInventors: Malek Y. S. Ibrahim, Scott E. Denmark
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Publication number: 20220165365Abstract: Methods, apparatus, and storage medium for determining a combination of coupling partners for a reaction according to input data. The method includes obtaining test input data for a test coupling partner of a test chemical type; obtaining selected input data for a selected coupling partner of a selected chemical type; determining, based on a reaction condition library, a candidate reaction condition set according to the test input data and selected input data, the candidate reaction condition set comprising a previous reaction condition; determining a candidate reaction vector representative of the candidate reaction condition set; inputting the candidate reaction vector into an input layer of a neural network set; and receiving an output at an output layer of the neural network set, the output indicative of a predicted yield from reacting the test coupling partner and the selected coupling partner under the candidate reaction condition set.Type: ApplicationFiled: November 23, 2021Publication date: May 26, 2022Inventors: Andrew F. Zahrt, Nicholas Ian Rinehart, Scott E. Denmark
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Publication number: 20210380627Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.Type: ApplicationFiled: June 10, 2021Publication date: December 9, 2021Inventors: Jonas Verhoeven, Guido Alfons F. Verniest, Johannes Wilhelmus John F. Thuring, Tongfei Wu, Vineet Pande, Lieven Meerpoel, Dirk Brehmer, Weimei Sun, Scott E. Denmark
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Patent number: 11059850Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.Type: GrantFiled: December 6, 2018Date of Patent: July 13, 2021Assignee: Janssen Pharmaceutica NVInventors: Jonas Verhoeven, Guido Alfons F. Verniest, Johannes Wilhelmus John F. Thuring, Tongfei Wu, Vineet Pande, Lieven Meerpoel, Dirk Brehmer, Weimei Sun, Scott E. Denmark
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Publication number: 20210055303Abstract: The present disclosure provides non-invasive methods for determining the gender of an embryo during in vitro embryo culture.Type: ApplicationFiled: August 24, 2020Publication date: February 25, 2021Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Marcello RUBESSA, Matthew B. WHEELER, Andrea AMBROSI, Scott E. DENMARK, Dianelys GONZALEZ-PENA
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Publication number: 20200369707Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.Type: ApplicationFiled: December 6, 2018Publication date: November 26, 2020Inventors: Jonas VERHOEVEN, Guido Alfons F. VERNIEST, Johannes Wilhelmus John F. THURING, Tongfei WU, Vineet PANDE, Lieven MEERPOEL, Dirk BREHMER, Weimei SUN, Scott E. DENMARK
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Publication number: 20200234798Abstract: Catalyst design in asymmetric reaction development has traditionally been driven by empiricism, wherein experimentalists attempt to qualitatively recognize structural patterns to improve selectivity. Machine learning algorithms and chemoinformatics can potentially accelerate this process by recognizing otherwise inscrutable patterns in large datasets. Herein we report a computationally guided workflow for chiral catalyst selection using chemoinformatics at every stage of development. Robust molecular descriptors that are agnostic to the catalyst scaffold allow for selection of a universal training set on the basis of steric and electronic properties. This set can be used to train machine learning methods to make highly accurate predictive models over a broad range of selectivity space. Using support vector machines and deep feed-forward neural networks, we demonstrate accurate predictive modeling in the chiral phosphoric acid-catalyzed thiol addition to N-acylimines.Type: ApplicationFiled: August 26, 2019Publication date: July 23, 2020Inventors: Scott E. Denmark, Andrew F. Zahrt, Jeremy J. Henle, Brennan T. Rose, Yang Wang, William T. Darrow
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Publication number: 20190161824Abstract: Disclosed herein is a method for extracting precious metals from supported catalysts. The precious metal in one embodiment is rhodium. The supported catalyst may be from equipment, such as a used catalytic converter. The method is carried out at low temperature, and does not require harsh conditions, such as the use of a strong acid. The method involves contacting the catalytic material with a polar molecule and a reactive gas.Type: ApplicationFiled: November 26, 2018Publication date: May 30, 2019Inventors: Malek Y.S. Ibrahim, Scott E. Denmark
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Publication number: 20140031562Abstract: A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an aldehyde or a hemiacetal. The reaction mixture includes a ruthenium catalyst, carbon monoxide at a level of at least 1 equivalent relative to the substrate, and water at a level of at least 1 equivalent relative to the substrate, and an amine at a level of from 0 to 0.5 equivalent relative to the substrate. The reaction mixture may also include a halide, and the equivalents of the amine may be similar to those of the halide. The reacting includes maintaining the reaction mixture at a temperature of at least 40° C. The method may be catalytic in metal, environmentally benign, amenable to large-scale applications, and applicable to a wide range of substrates.Type: ApplicationFiled: August 28, 2009Publication date: January 30, 2014Applicant: The Board of Trustees of the University of IllinoiInventors: Scott E. Denmark, Selena Milicevic, Son T. Nguyen
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Patent number: 6867323Abstract: Improved methods for generating a —C—C— bond by cross-coupling of a transferable group with an acceptor group. The transferable group is a substituent of an organosilicon nucleophile and the acceptor group is provided as an organic electrophile. The reaction is catalyzed by a Group 10 transition metal complex (e.g., Ni, Pt or Pd), particularly by a palladium complex. Certain methods of this invention use improved organosilicon nucleophiles which are readily prepared, can give high product yields and exhibit high stereoselectivity. Methods of this invention employ activating ions such as halides, hydroxide, hydride and silyloxides. In specific embodiments, organosilicon nucleophilic reagents of this invention include siloxanes, particularly cyclic siloxanes. The combination of the cross-coupling reactions of this invention with ring-closing metathesis, hydrosilylation and intramolecular hydrosilylation reactions provide useful synthetic strategies that have wide application.Type: GrantFiled: June 6, 2001Date of Patent: March 15, 2005Assignee: The Board of Trustees of the University of IllinoisInventors: Scott E. Denmark, Jun Young Choi, Daniel Wehrli, Zhicai Wu, Luc Neuville, Weitao Pan, Ramzi F. Sweis, Zhigang Wang, Shyh-Ming Yang
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Publication number: 20020183516Abstract: Improved methods for generating a —C—C— bond by cross-coupling of a transferable group with an acceptor group. The transferable group is a substituent of an organosilicon nucleophile and the acceptor group is provided as an organic electrophile. The reaction is catalyzed by a Group 10 transition metal complex (e.g., Ni, Pt or Pd), particularly by a palladium complex. Certain methods of this invention use improved organosilicon nucleophiles which are readily prepared, can give high product yields and exhibit high stereo selectivity. Methods of this invention employ activating ions such as halides, hydroxide, hydride and silyloxides. In specific embodiments, organosilicon nucleophilic reagents of this invention include siloxanes, particularly cyclic siloxanes. The combination of the cross-coupling reactions of this invention with ring-closing metathesis, hydrosilylation and intramolecular hydrosilylation reactions provide useful synthetic strategies that have wide application.Type: ApplicationFiled: June 6, 2001Publication date: December 5, 2002Inventors: Scott E. Denmark, Jun Young Choi, Daniel Wehrli, Zhicai Wu, Luc Neuville, Weitao Pan, Ramzi F. Sweis, Zhigang Wang, Shyh-Ming Yang