Patents by Inventor Scott H. Watterson

Scott H. Watterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acridone inhibitors of IMPDH enzyme
    Patent number: 7312209
    Abstract: Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ?O and ?S; W is —C(?O)—, —S(?O)—, or —S(O)2—; or W may be —CH2— if X is —C(?O)—; X is selected from —CH2—, —N(R4)—, and —O—, except that when W is —CH2—, X is —C(?O)—; Y is a bond or —C(R40)(R45)—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and R1, R2, R24, and R25 are as defined in the specification.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 25, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, Ping Chen, T. G. Murali Dhar, Henry H. Gu, Yufen Zhao
  • 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same
    Patent number: 7008958
    Abstract: Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme, wherein R3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R1, R2, R4, and R5 are as defined in the specification.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: March 7, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott H. Watterson, T. G. Murali Dhar, Edwin J. Iwan wicz
  • Heterocycles that are inhibitors of IMPDH enzyme
    Patent number: 6919335
    Abstract: Compounds of the formula wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is CR4 or N; X5 is CR5 or N; and X6 is CR6 or N are useful as inhibitors of IMPDH enzyme. Thus, these compounds can be used as therapeutic agents for IMPDH-associated disorders.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: July 19, 2005
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, T. G. Murali Dhar, William J. Pitts, Henry H. Gu
  • Heterocyclic acridone inhibitors of IMPDH enzyme
    Patent number: 6916809
    Abstract: Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ?O and ?S; W is —C(?O)—, —S(?O)—, or —S(O)2—; or W may be —CH2— if X is —C(?O)—; X is selected from —CH2—, —N(R4)—, and —O—, except that when W is —CH2—, X is —C(?O)—; Y is a bond or —C(R40)(R45)—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X1, X2, X3, X4, X5, X6, X7, X8, X9, X10 and X11 are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 12, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ping Chen, T.G. Murali Dhar, Edwin J. Iwanowicz, Scott H. Watterson, Henry Gu, Yufen Zhao
  • Acridone inhibitors of IMPDH enzyme
    Publication number: 20040053955
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: December 20, 2002
    Publication date: March 18, 2004
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, Ping Chen, T. G. Murali Dhar, Henry H. Gu, Yufen Zhao
  • 2-Substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same
    Publication number: 20030232866
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: May 20, 2003
    Publication date: December 18, 2003
    Inventors: Scott H. Watterson, T.G. Murali Dhar, Edwin J. Iwanowicz
  • Heterocyclic acridone inhibitors of IMPDH enzyme
    Publication number: 20030181497
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: December 20, 2002
    Publication date: September 25, 2003
    Inventors: Ping Chen, T. G. Murali Dhar, Edwin J. Iwanowicz, Scott H. Watterson, Henry Gu, Yufen Zhao
  • Amino-substituted compounds useful as inhibitors of IMPDH enzyme
    Patent number: 6617323
    Abstract: The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), wherein X is —C(O)—, —C(S)—, or —S(O)2—; A is an optionally-substituted saturated or unsaturated monocyclic or bicyclic ring; B is a saturated or unsaturated monocyclic or bicyclic ring system having at least one substituent Q which is selected from R7 and R8; R7 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R7 is substituted with R8 is selected from (C0-C6)alkyl, (C2-C6)alkenyl and (C2-C6)alkynyl and R8 is substituted with and Z1 through Z5 are as defined in the specification.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: September 9, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Edwin J. Iwanowicz, Katerina Leftheris, Chunjian Liu, Toomas Mitt, Scott H. Watterson
  • Amino-substituted compounds useful as inhibitors of impdh enzyme
    Publication number: 20020183315
    Abstract: The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), 1
    Type: Application
    Filed: May 23, 2002
    Publication date: December 5, 2002
    Inventors: Edwin J. Iwanowicz, Katerina Leftheris, Chunjian Liu, Toomas Mitt, Scott H. Watterson
  • Inhibitors of IMPDH enzyme
    Patent number: 6420403
    Abstract: The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: July 16, 2002
    Inventors: Edwin J. Iwanowicz, T. G. Murali Dhar, Katerina Leftheris, Chunjian Liu, Toomas Mitt, Scott H. Watterson, Joel C. Barrish
  • Heterocycles that are inhibitors of IMPDH enzyme
    Publication number: 20020040022
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 23, 2001
    Publication date: April 4, 2002
    Inventors: Edwin J. Iwanowicz, Scott H. Watterson, T.G. Murali Dhar, William J. Pitts, Henry H. Gu