Patents by Inventor Scott I. Klein

Scott I. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
    Patent number: 5053392
    Abstract: Disclosed are novel amino acid derivatives of the formula: ##STR1## wherein X is H, amidino or ##STR2## Y is H, amino or ##STR3## Z is ##STR4## OR.sub.1 or a naturally occurring L-amino acid, bounded to the carbon atom at the .alpha.-amino position;R is alkyl, aryl or aralkyl;R.sub.1 and R.sub.2 are independently H, alkyl, aryl, aralkyl or allyl;m is 1 through 5;n is 0 through 4; andpharmaceutically acceptable salts thereof, that inhibit platelet aggregation and thrombus formation in mammalian blood.
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: October 1, 1991
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino
  • Anti-thrombotic peptides and pseudopeptides
    Patent number: 5051405
    Abstract: Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof containing certain amino acids and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: September 24, 1991
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Scott I. Klein, Bruce F. Molino, Mark Czekaj, Charles J. Gardner
  • Anti-thrombotic peptides and pseudopeptides
    Patent number: 4952562
    Abstract: Disclosed are novel peptides and pseudopeptides and pharmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: August 28, 1990
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Scott I. Klein, Bruce F. Molino, Mark Czekaj, Charles J. Gardner, Jeffrey C. Pelletier
  • Benzoxepins as intermediates to 5HT.sub.3 antagonists
    Patent number: 4924010
    Abstract: Certain specific substituted 9-N-(1-azabicycolo-[2.2.2.]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-ben zoxepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic activity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: May 8, 1990
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Raymond Youssefyeh, Scott I. Klein, Henry F. Campbell, Donald E. Kuhla
  • Certain benzoxepins and their pharmaceutical compositions and methods
    Patent number: 4859683
    Abstract: Certain specific substituted 9-N-(1-azabicyclo[3.3.1.]nonan-4-yl)carboxamido-2,3,4,5-tetrahydro-1-benzo xepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic activity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.
    Type: Grant
    Filed: February 4, 1988
    Date of Patent: August 22, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Raymond Youssefyeh, Scott I. Klein, Henry F. Campbell, Donald E. Kuhla
  • Quinuclidyl benzoxepins as 5-HT.sub.3 antagonists
    Patent number: 4857517
    Abstract: Certain specific substituted 9-N-(1-azabicyclo-[2.2.2.]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-benz oxepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic acticity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.
    Type: Grant
    Filed: February 4, 1988
    Date of Patent: August 15, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Raymond Youssefyeh, Scott I. Klein, Henry F. Campbell, Donald E. Kuhla