Abstract: A pump for inducing flow within a vascular system comprises a cannula having a first configuration for deployment within the vascular system and a second configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. An impeller is configured to induce the fluid flow by rotation about an axis. The impeller has a first radius in the first configuration and a second radius in the second configuration, where the second radius is greater than the first radius.

Abstract: A pump for inducing flow within a vascular system comprises a cannula having a first configuration for deployment within the vascular system and a second configuration for directing the fluid flow within the vascular system, where the second configuration has a greater diameter than the first configuration. An impeller is configured to induce the fluid flow by rotation about an axis. The impeller has a first radius in the first configuration and a second radius in the second configuration, where the second radius is greater than the first radius.

Abstract: A medical device guide having an inner member having a proximal end, a distal end, and at least one lumen therein. An outer member surrounds the proximal portion of the inner member such that the distal end of the inner member projects beyond the distal end of the outer member, the portion of the inner member being sufficient flexible to flex with a guide wire extending through the lumen. The outer member is sufficiently stiff that the proximal end of the medical device guide can be engaged by a driven by a medical device advancer.

Abstract: Various systems for advancing medical devices within a subject's body are provided that configured to engage the outer surface of the medical device at a number of points about the circumference of the medical device, to thereby grip the medical device for enabling advancement of the device. The advancing systems include engaging portions configured to engage the outer surface of a medical device at a number of points about the circumference of the medical device. The engaging portions preferably engage opposing sides of the medical device's outer surface over a predetermined longitudinal length, to clamp against a longitudinal portion of the medical device that provides improved surface contact with the medical device over conventional roller guides. Various methods for performing medical procedures utilizing various medical devices and advancer systems are also provided.

Abstract: A medical device guide having an inner member having a proximal end, a distal end, and at least one lumen therein. An outer member surrounds the proximal portion of the inner member such that the distal end of the inner member projects beyond the distal end of the outer member, the portion of the inner member being sufficient flexible to flex with a guide wire extending through the lumen. The outer member is sufficiently stiff that the proximal end of the medical device guide can be engaged by a driven by a medical device advancer.

Abstract: An advancer system is described for moving an elongate medical device within a body. The system includes a drive unit having a motor. The drive unit is configured to translate movement of the motor to the device so as to alternately advance and retract the device relative to the body. The advancer system also includes a user-operable control system configured to control the drive unit. The control system can interface with a magnetic navigation system. The above-described system allows an operating physician to control catheter advancement and retraction while remaining outside an x-ray imaging field. Thus the physician is freed from repeated x-ray exposure.

Abstract: A system for moving an elongate medical device has at least one drive element for engaging and moving an elongate medical device. Various embodiments provide for moving the separate inner and outer elements of a telescoping medical device. Some systems also provide for the rotation of a rotatable distal element on a rotatable medical device or the rotation of extension element in a telescoping medical device.

Abstract: A guide for controlling the orientation of a medical device includes a cannula having a lumen therein for the medical device, and a guide member having a passage therein for receiving and directing the medical device, the guide member being movably mounted in the cannula for movement. The guide member can be magnetically responsive to an externally applied magnetic field, or can be magnetically responsive to an externally applied magnetic field when a magnetic medical device is in the passage, and/or it can be mechanically responsive.

Abstract: An automated system for navigating a medical device through the lumens and cavities in an operating region in a patient. The system includes an elongate medical device, having a proximal end and a distal end adapted to be introduced into the operating region. The system also includes an imaging system for displaying an image of the operating region, including a representation of the distal end of the medical device in the operating region. The system also includes a localization system for determining the position of the medical device in a frame of reference translatable to the displayed image of the imaging system. Finally, the system includes a system for orienting the medical device in a selected direction in the operating region, this system may be, for example, a magnetic navigation system which acts through the interaction of magnetic fields associated with the medical device inside the operating region and at least one external source magnet outside the patient's body.

Abstract: A deflection mechanism for selectively inducing a bend in a catheter body includes an elongated deflection wire extending within a deflection lumen of the catheter body and into a handle. A guide track is formed within the handle and a thumb wheel is mounted proximal to the elongated guide track within the handle and supports a pinion gear; the thumb wheel and the pinion gear are adapted to be rotated about a common thumb wheel axis, which extends substantially perpendicular to the longitudinal axis. A rack arm extends obliquely to the longitudinal axis of the handle and includes runners received by the guide track, an attachment point coupling the deflection wire to the rack arm and a linear rack engaging the pinion gear. Rotation of the thumb wheel in a first direction draws the deflection wire proximally through the deflection lumen.