Patents by Inventor Scott Lokey

Scott Lokey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE-PEPTOID SCAFFOLDS
    Publication number: 20220002346
    Abstract: Molecular scaffolds, including cyclic peptides, that have high (large) cell permeability.
    Type: Application
    Filed: July 2, 2021
    Publication date: January 6, 2022
    Inventors: R. Scott LOKEY, Akihiro FURUKAWA
  • Cell permeable cyclic peptide scaffolds
    Patent number: 11001609
    Abstract: Aspects of the present disclosure include cell permeable cyclic peptide scaffolds that include a hexapeptide composed of naturally or non-naturally occurring amino acids. Pharmaceutical compositions having one or more of the cell permeable cyclic peptide scaffolds and pharmaceutically acceptable excipient are also provided. Methods for using the subject cell permeable cyclic peptide scaffolds are also described.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: May 11, 2021
    Assignee: The Regents of the University of California
    Inventor: Scott Lokey
  • Cell Permeable Cyclic Peptide Scaffolds
    Publication number: 20200157149
    Abstract: Aspects of the present disclosure include cell permeable cyclic peptide scaffolds that include a hexapeptide composed of naturally or non-naturally occurring amino acids. Pharmaceutical compositions having one or more of the cell permeable cyclic peptide scaffolds and pharmaceutically acceptable excipient are also provided. Methods for using the subject cell permeable cyclic peptide scaffolds are also described.
    Type: Application
    Filed: April 23, 2018
    Publication date: May 21, 2020
    Inventor: Scott LOKEY
  • USE OF TRIFLUOROACETAMIDE FOR N-TERMINAL PROTECTION
    Publication number: 20150011778
    Abstract: This disclosure teaches the novel use of trifluoroacetamide for N-terminal protection. The disclosure also teaches novel compositions and chemical structures associated therewith. These methods and compositions are useful for site-specific methylation of peptide backbone amides, performed, for example, to modulate the pharmacokinetic properties of peptide drugs.
    Type: Application
    Filed: February 19, 2013
    Publication date: January 8, 2015
    Inventors: Scott Lokey, Rushia Turner
  • Phalloidin derivatives and methods for their synthesis
    Publication number: 20120231996
    Abstract: The invention provides a cyclomonomer having actin-binding activity. The cyclomonomer is of utility for the study of the molecular biology of actin polymerization. The cyclomonomer is also useful for the study of and treatment of the toxic effects of Amanita sp. poisoning.
    Type: Application
    Filed: June 9, 2011
    Publication date: September 13, 2012
    Inventors: R. Scott Lokey, Laura A. Schuresko
  • Phalloidin derivatives and methods for their synthesis
    Patent number: 7964702
    Abstract: The invention provides a cyclomonomer having actin-binding activity. The cyclomonomer is of utility for the study of the molecular biology of actin polymerization. The cyclomonomer is also useful for the study of and treatment of the toxic effects of Amanita sp. poisoning.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: June 21, 2011
    Assignee: The Regents of the University of California
    Inventors: R. Scott Lokey, Laura A. Schuresko
  • STRUCTURE-BASED APPROACH TO DESIGN OF INHIBITORS OF PROTEIN-PROCESSIVITY FACTOR INTERACTIONS
    Publication number: 20100298164
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Application
    Filed: July 2, 2010
    Publication date: November 25, 2010
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon J. Zuccola, Kristie Grove Bridges, Scott Lokey
  • Structure-based approach to design of inhibitors of protein-processivity factor interactions
    Patent number: 7388070
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: June 17, 2008
    Assignee: President and Fellows of Harvard College
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon J. Zuccola, Kristie Grove Bridges, Scott Lokey
  • Structure-based approach to design of protein-processivity factor interactions
    Publication number: 20070055459
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Application
    Filed: November 6, 2006
    Publication date: March 8, 2007
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon Zuccola, Kristie Bridges, Scott Lokey