Patents by Inventor Scott M. Berry
Scott M. Berry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958403Abstract: A work machine can include a machine frame; and a component box holding a plurality of electrical components mounted to a roof of the machine frame; wherein the component box includes a plurality of indicator light sets exposed on an outer surface of the component box, wherein the plurality of indicator light sets are configured to indicate to external personnel a mode of operation of the work machine.Type: GrantFiled: May 23, 2022Date of Patent: April 16, 2024Assignee: Caterpillar Inc.Inventors: Adam L. Berry, Ashley Dallas Menges, William Clayton Martin, Ryan P. Pecinovsky, Scott M. Toombs
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Patent number: 11618021Abstract: A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.Type: GrantFiled: June 26, 2020Date of Patent: April 4, 2023Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Joshua M. Lang, Duane S. Juang, Scott M. Berry, Tamara S. Rodems
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Publication number: 20210255071Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: ApplicationFiled: April 7, 2021Publication date: August 19, 2021Inventors: David J. Beebe, Ben P. Casavant, David J, Guckenberger, Scott M. Berry
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Publication number: 20210215684Abstract: A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes a first plate having a first region for receiving at least a portion of the sample. A second plate is spaced from the first plate by a distance and has a first region for receiving a reagent. A force attracts the target bound solid phase substrate toward the first region of the second plate such that the target bound solid phase substrate in the portion of the sample are drawn through the air gap and into the reagent by the force.Type: ApplicationFiled: March 10, 2021Publication date: July 15, 2021Inventors: David J. Beebe, Scott M. Berry
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Patent number: 11029310Abstract: A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes a first plate having a first region for receiving at least a portion of the sample. A second plate is spaced from the first plate by a distance and has a first region for receiving a reagent. A force attracts the target bound solid phase substrate toward the first region of the second plate such that the target bound solid phase substrate in the portion of the sample are drawn through the air gap and into the reagent by the force.Type: GrantFiled: March 14, 2013Date of Patent: June 8, 2021Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Scott M. Berry
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Patent number: 10996149Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: GrantFiled: August 30, 2017Date of Patent: May 4, 2021Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Publication number: 20200406260Abstract: A method of sample preparation for streamlined multi-step assays is provided. The method includes the step of providing a microfluidic device including a reservoir defined by a surface configured to repel an aqueous solution. A dried reagent is provided on a portion of the surface and the reservoir is filled with an oil. A first droplet formed from the aqueous solution is positioned on the dried reagent so to pick-up and re-dissolve the dried reagent therein so as to expose the portion of the surface. In addition, a second droplet of an aqueous solution may be deposited on a hydrophilic spot patterned on the surface. A magnetic force may be configured to interact magnetically with the paramagnetic beads within the first droplet to move the droplet through the oil in the reservoir or to move the paramagnetic beads from the first droplet, through the oil, into the second droplet.Type: ApplicationFiled: June 26, 2020Publication date: December 31, 2020Inventors: David J. Beebe, Joshua M. Lang, Duane S. Juang, Scott M. Berry, Tamara S. Rodems
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Patent number: 10640530Abstract: A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method includes the steps of capturing the fraction-bound solid phase substrate and bringing an isolation buffer and the fraction-bound solid phase substrate into contact to purify the captured fraction-bound solid phase substrate.Type: GrantFiled: February 8, 2018Date of Patent: May 5, 2020Assignee: Wisconsin Alumni Research FoundationInventors: David Beebe, Lindsay Strotman, Scott M. Berry
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Patent number: 10564077Abstract: A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein to capture a desired fraction of the biological sample. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone multiple other positions adjacent various purification, protein analysis, separation and extraction zones. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the other zones to perform a multi-step assay on the isolated fraction within the device.Type: GrantFiled: March 15, 2013Date of Patent: February 18, 2020Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Joshua M. Lang, Benjamin P. Casavant, Scott M. Berry, Lindsay N. Strotman
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Patent number: 10441950Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: GrantFiled: July 17, 2018Date of Patent: October 15, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Patent number: 10434513Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.Type: GrantFiled: June 8, 2016Date of Patent: October 8, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Scott M. Berry, Hannah M. Pezzi
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Patent number: 10391495Abstract: A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample received in the well has a concave meniscus. A deformation tool is engageable with the sample container and is moveable between a first disengaged position wherein the deformation tool is spaced from the sample container and a second, engaged position wherein the deformation tool engages and deforms at least a portion of the sample container such that the meniscus of the sample in the well is converted from concave to convex.Type: GrantFiled: August 22, 2016Date of Patent: August 27, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Hannah M. Pezzi, Scott M. Berry
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Publication number: 20180318827Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Patent number: 10040062Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.Type: GrantFiled: January 14, 2014Date of Patent: August 7, 2018Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Publication number: 20180162901Abstract: A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method includes the steps of capturing the fraction-bound solid phase substrate and bringing an isolation buffer and the fraction-bound solid phase substrate into contact to purify the captured fraction-bound solid phase substrate.Type: ApplicationFiled: February 8, 2018Publication date: June 14, 2018Inventors: David Beebe, Lindsay Strotman, Scott M. Berry
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Publication number: 20180095018Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: ApplicationFiled: August 30, 2017Publication date: April 5, 2018Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Publication number: 20180050338Abstract: A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. The sample received in the well has a concave meniscus. A deformation tool is engageable with the sample container and is moveable between a first disengaged position wherein the deformation tool is spaced from the sample container and a second, engaged position wherein the deformation tool engages and deforms at least a portion of the sample container such that the meniscus of the sample in the well is converted from concave to convex.Type: ApplicationFiled: August 22, 2016Publication date: February 22, 2018Inventors: David J. Beebe, David J. Guckenberger, JR., Hannah M. Pezzi, Scott M. Berry
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Publication number: 20170356829Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.Type: ApplicationFiled: June 8, 2016Publication date: December 14, 2017Inventors: David J. Beebe, David J. Guckenberger, JR., Scott M. Berry, Hannah M. Pezzi
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Patent number: 9766166Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.Type: GrantFiled: January 9, 2013Date of Patent: September 19, 2017Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
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Patent number: 9459189Abstract: A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein and a second zone for receiving an isolation fluid therein. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone and a second position adjacent the isolation zone. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the isolation zone in response to the force moving from the first position to the second position.Type: GrantFiled: April 2, 2014Date of Patent: October 4, 2016Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, Scott M. Berry, David J. Guckenberger, Ben P. Casavant