Abstract: An implantable device for delivering a drug includes a housing and a source of drug contained within the housing. An orifice mechanism is located at the housing and communicates with the source of drug. The orifice mechanism includes an inner member having a proximal end and a distal end and a winding helically wound around the inner member. The winding and the inner member define a first channel for carrying the drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding. The drug is carried by the orifice mechanism and dispensed outside of the housing.

Abstract: An orifice device for delivering one or more drugs includes an inner member having a proximal end and a distal end; and a plurality of windings helically wound around the inner member. Each winding defines a separate layer and each winding includes at least one wire helically wound around the inner member. The plurality of windings and the inner member define at least two separate carrying one or more drugs therethrough. An inlet is at the proximal end of each of the plurality of windings and an outlet is at the distal end of the plurality of windings. At least one of the plurality of windings has a plurality of distinct wires helically wound in parallel around the inner member and at least one of the plurality of windings respectively. In some embodiments, the plural and the inner member define at least three separate channels for carrying one or more drugs therethrough. In some embodiments, at least two of the plurality of distinct wires have a different dimension.

Abstract: An orifice device for delivering a drug includes an inner member having a proximal end and a distal end. A winding is helically wound around the inner member. The winding and the inner member define a first channel for carrying a drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding.

Abstract: A device for delivering a drug includes a body having a proximal end and a distal end and an opening in the distal end thereof. An orifice mechanism at the distal end of the body communicates with the opening. The orifice mechanism includes an inner member having a proximal end and a distal end; a winding helically wound around the inner member; and wherein the winding and the inner member define a first channel for carrying a drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the inner member.

Abstract: A method for manufacturing an orifice mechanism includes the steps of providing a mandrel having a length and helically wrapping a winding around at least a portion of the length of the mandrel. The mandrel and the winding define a first channel for carrying a drug therethrough. An inlet is at one end of the winding and an outlet is at the other end of the winding.

Abstract: An implantable device for delivering a drug includes a housing and a source of drug contained within the housing. An orifice mechanism is located at the housing and communicates with the source of drug. The orifice mechanism includes an inner member having a proximal end and a distal end and a winding helically wound around the inner member. The winding and the inner member define a first channel for carrying the drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding. The drug is carried by the orifice mechanism and dispensed outside of the housing.

Abstract: A long term oxygen therapy system having an oxygen supply directly linked with a patient's lung or lungs may be utilized to more efficiently treat hypoxia caused by chronic obstructive pulmonary disease such as emphysema and chronic bronchitis. The system includes an oxygen source, one or more valves and fluid carrying conduits. The fluid carrying conduits link the oxygen source to diseased sites within the patient's lungs. A collateral ventilation bypass trap system directly linked with a patient's lung or lungs may be utilized to increase the expiratory flow from the diseased lung or lungs, thereby treating another aspect of chronic obstructive pulmonary disease. The system includes a trap, a filter/one-way valve and an air carrying conduit. In order for the system to be effective, an air-tight seal between the parietal and visceral pleurae is required. Chemical pleurodesis is utilized for creating the seal.

Abstract: An internet-based robust universal air taxi and charter system utilizes a centralized database and server to match trips with available aircraft in which the end user is presented with information about various available aircraft. To avoid out-of-date or erroneous information, all information is automatically inputted by aircraft vendors who use the central server for routine daily data entry for their businesses, with all vendors being continuously connected to the central server without the necessity of logging on to upload any additional data. Thus, the central server is used in the day-to-day business of the aircraft vendors. This provides automatically updated vendor files on a real-time basis to increase reliability and accuracy. In one embodiment chartering is accomplished by embedding specialized software tools at every travel agency, vendor and/or broker who subscribes.

Abstract: A modified class of nickel aluminide (NiAl) type material is disclosed having useful amounts of toughness and ductility at low temperatures, e.g. room temperature. The basic NiAl material is modified with an additional of the material such as cobalt which produces a structure which is susceptible to undergoing a martensitic transformation. The martensitic structure when produced results in a significant increase in toughness and ductility at low temperatures.