Abstract: The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.

Abstract: An arrangement of interconnected timers is provided for operation with a microprocessor programmed to determine time delay counts that are fed out to these timers such that the timers can take care of the actual task of firing GTO inverter switches or not firing GTO inverter switches coupled with an AC traction motor for a vehicle. It is necessary to have correct transitions between the minus GTO switch and the plus GTO switch being ON for providing the desired motor voltage conditions with minimum electromagnetic interference in relation to the power supply. In addition the use of timer queues in complicated synthesis modes like the PWM and the quasi six-step operates to give the microprocessor adequate operating time for reasonable control signal time duration calculations. The timers are synchronized in hardware by a single crystal frequency, and they are synchronized in software such that the three phase independent waveforms stay 120.degree. apart.