Abstract: The present invention provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of bictegravir, or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.

Abstract: The disclosure is directed to methods of treating subjects infected with HIV, once daily, with single unit dosage forms that include darunavir (or a hydrate or solvate thereof), cobicistat, emtricitabine, and a tenofovir prodrug, or salt thereof.

Abstract: The disclosure is directed to methods of treating subjects infected with HIV, once daily, with single unit dosage forms that include darunavir (or a hydrate or solvate thereof), cobicistat, emtricitabine, and a tenofovir prodrug, or salt thereof.

Abstract: The invention provides a solid oral dosage form comprising tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides a solid oral dosage form comprising tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.

Abstract: Substrates and arrays that can be used for biological analysis with particle beam instruments are provided. In one embodiment, a substrate for an array is constructed and arranged to be used for imaging samples with a particle beam instrument such as a transmission electron microscope. The substrate can include one or more ligands (e.g., nucleic acids, polypeptides, oligosaccharides, and synthetic polymers) which may form an array. Corresponding changes in labeling chemistry can allow for ligands, binding partners and other relevant materials to be identifiable, quantitatable, and even sequenceable via modified forms of electron microscopy. In certain embodiments, the array dimensions are on the order of nanometers per functional region rather than micrometers as in certain conventional arrays. With these dimensions, smaller amounts of sample material can be used and more accurate genetic analyses performed.

Abstract: An improved method for treating HIV infection comprising administering to a human in need of such treatment a combination of a therapeutically effective amount of tipranavir or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of capravirine or a pharmaceutically acceptable salt thereof.