Abstract: A portable system for substantially automated monitoring of nerve conduction velocity through the carpal tunnel of a patient includes an electrode supporting structure which supports stimulating and pickup electrodes in a predetermined spatial relationship so as to contact the patient's arm and hand. The electrode supporting structure is a part of a housing which contains stimulating signal generating and response signal processing circuitry, which operates substantially automatically under control of a microprocessor. The microprocessor controls generation of stimulating pulses and determines the elapsed time until the occurrence of a predetermined response signal characteristic, such as its peak. Data relating to nerve conduction time or velocity measurements and response signal waveform are stored in a removable memory to permit later analysis and treatment recommendation by a physician.