Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.

Abstract: A delivery apparatus for a medical device can include a handle, a shaft, a plurality of sleeves, and a suture. The shaft includes a proximal end portion coupled to the handle and is configured to be disposed outside of a patient's body during an implantation procedure and a distal end portion configured to be disposed inside a patient's body during the implantation procedure. Each of the sleeves includes a connection portion coupled to the distal end portion of the shaft and a receiving portion configured to receive an apex of a stent or a prosthetic heart valve. The suture extends through the shaft and the sleeves and is configured for releasably securing the stent or the prosthetic heart valve to the receiving portions of the sleeves.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: The present disclosure provides, inter alia, ADCs with charge variant chemical linkers useful in treating various diseases such as cancer and autoimmune disorders.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: A method for use with a problem is provided. The method comprises activity on the part of a user. The user activity is structured to include a locate step involving a definition of the problem and ideation of factors that are material to the problem or to the utility of possible solutions to the problem. The user activity is also structured to include a navigate step following the locate step and involving a ranking of the factors in terms of the importance of the factor to the problem and the extent to which the factor can be controlled, a selection amongst the factors of factors that are relatively more important and/or relatively more susceptible to control, than the others, a review of the selected factors to identify viewpoints related to the factors, and a review of the selected factors from the identified viewpoints to ideate a body of insights.

Abstract: Methods and systems are provided for a systematic approach to computer aided inventing. In a modeling environment, a model representing an item, composition or process can be defined and configured using the lexicon and specification of an innovation database. In the model, objects can be indentified, defined, and configured to provide the model with constituent products, components, features and materials. An innovation engine automatically applies one or more morphs from the innovation database to the objects or the model to generate morphed versions of the model that may provide innovations of, or invention to, the item, composition or process represented by the model.

Abstract: Methods and systems are provided for a systematic approach to computer aided inventing. In a modeling environment, a model representing any item, composition or process can be defined and configured using the lexicon and specification of an innovation database. In the model, objects can be identified, defined, and configured to provide the model with constituent products, components, features and materials. An innovation engine automatically applies one or more morphs from the innovation database to the objects of the model to generate morphed versions of the model that may provide innovations of or invention to the item, composition or process represented by the model.

Abstract: Methods and systems are provided for a systematic approach to computer aided inventing. In a modeling environment, a model representing any item, composition or process can be defined and configured using the lexicon and specification of an innovation database. In the model, objects can be identified, defined, and configured to provide the model with constituent products, components, features and materials. An innovation engine automatically applies one or more morphs from the innovation database to the objects of the model to generate morphed versions of the model that may provide innovations of or inventions to the item, composition or process represented by the model.

Abstract: Improvements are disclosed for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus comprises a cylindrical mold roll rotatable about an axis and defining small fastener element-shaped mold cavities in the surface thereof, and pressure-applying means to apply operating pressure to force the resin into the cavities at a pressure zone. The pressure-applying means and mold roll define a mold gap therebetween for forming the base web. The advantageous use of relatively long mold rolls, to produce a correspondingly wide web, and the use of higher molding pressures, e.g. to form very small fastener elements, is enabled by various improvements, including means to maintain the mold gap at a desired thickness profile across the length of the molding region of the mold roll under operating pressure. In some cases the pressure-applying means includes a pressure roll, in other cases it includes a resin nozzle assembly or pressure head.

Abstract: Improvements are disclosed for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus comprises a cylindrical mold roll rotatable about an axis and defining small fastener element-shaped mold cavities in the surface thereof, and pressure-applying means to apply operating pressure to force the resin into the cavities at a pressure zone. The pressure-applying means and mold roll define a mold gap therebetween for forming the base web. The advantageous use of relatively long mold rolls, to produce a correspondingly wide web, and the use of higher molding pressures, e.g. to form very small fastener elements, is enabled by various improvements, including means to maintain the mold gap at a desired thickness profile across the length of the molding region of the mold roll under operating pressure. In some cases the pressure-applying means includes a pressure roll, in other cases it includes a resin nozzle assembly or pressure head.

Abstract: Improvements are disclosed for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus comprises a cylindrical mold roll rotatable about an axis and defining small fastener element-shaped mold cavities in the surface thereof, and pressure-applying means to apply operating pressure to force the resin into the cavities at a pressure zone. The pressure-applying means and mold roll define a mold gap therebetween for forming the base web. The advantageous use of relatively long mold rolls, to produce a correspondingly wide web, and the use of higher molding pressures, e.g. to form very small fastener elements, is enabled by various improvements, including means to maintain the mold gap at a desired thickness profile across the length of the molding region of the mold roll under operating pressure. In some cases the pressure-applying means includes a pressure roll, in other cases it includes a resin nozzle assembly or pressure head.

Abstract: Improvements are disclosed for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus comprises a cylindrical mold roll rotatable about an axis and defining small fastener element-shaped mold cavities in the surface thereof, and pressure-applying means to apply operating pressure to force the resin into the cavities at a pressure zone. The pressure-applying means and mold roll define a mold gap therebetween for forming the base web. The advantageous use of relatively long mold rolls, to produce a correspondingly wide web, and the use of higher molding pressures, e.g. to form very small fastener elements, is enabled by various improvements, including means to maintain the mold gap at a desired thickness profile across the length of the molding region of the mold roll under operating pressure. In some cases the pressure-applying means includes a pressure roll, in other cases it includes a resin nozzle assembly or pressure head.

Abstract: A fastener member (10) useful for separable engagement with surface fibers of a low-loft, non-woven fabric, or the like, has a base web (12) and a multitude of fastener elements (14) formed with and extending from the base web (12). The fastener elements have a profile that comprises an elongated stem portion (22) adjacent the base web (12) and including at an acute angle to the base. A crook portion (24) is formed on the end of the stem and is directed oppositely to the direction of inclination of the stem, being exposed for engaging a mating fastening member (32). The acute angle of the stem of the elements (14) enables them to flex toward the base. Offset pair of such elements (14) can operatively move in a pincer-type motion to engage fibers (32) and to retain engaged fibers. Other element configurations are disclosed. The fastener member has particular application for fastening of disposable products such as garments and diapers.

Abstract: Improvements for an apparatus for continuously molding small fastener elements integral with a base web from a flowable resin. The apparatus includes a rotating cylindrical mold roll defining small fastener element-shaped mold cavities in its peripheral surface. Resin is forced into the cavities under pressure at a gap between the mold roll and either a pressure roll, a pressure nozzle, or a belt. The improvements compensate for the crowning of the mold roll under high molding pressures, enabling the molding of wider products. Other gap controls include skewing, product thickness feedback, and active roll bending. Some pressure and backup rolls have compliant surfaces for conforming to the mold roll to avoid high contact loads that can damage the cavities.

Abstract: Blank washer for cleaning individual sheet metal blanks with a drawing compound liquid suitable for press operations which employs pressurized liquid vortex diffuser means to replace conventional scrubbing brushes. An enclosure with air knives at entrance and exit to the blank washer provides closed loop recirculating of both air and cleaning liquid, which is filtered and repumped to plenum chambers feeding individual vortex diffuser cylindrical outlets which discharge liquid vortexes in close proximity to the passing sheet metal.

Abstract: Pineapple processing method comprising automatic steps of slicing the raw pineapple, positioning individual slices on conveyor pallets progressing through sequential processing stations for individually scanning each slice, recording an image of each slice based on distinguishing relative transmissivity of edible fruit from unedible shell, flaws such as eyes, and core, using control responsive to recorded image for cutting irregular perimeter path along the boundary line of edible fruit, determining maximum diameter of edible cylindrical slice within the irregular perimeter path for selective size whole slice processing, followed by small piece processing of remaining perimeter of edible fruit.