Abstract: A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.

Abstract: A piston pump with a working fluid region, drive mechanism and a lubricating fluid region. The pump's working fluid region is configured to circulate a working fluid through an external circuit, such as a micro combined heat and power system. The working fluid region is separated from its lubricating fluid region by a seal. By keeping a sufficient quantity of lubricating fluid against the lubricating fluid region side of the seal, leakage of working fluid from the working fluid region to the lubricating fluid region can be significantly reduced. The pump may include various alternative forms of lubricant pumping devices to effect transport and pressurization of the lubricating fluid, including a variable volume pumping cavity, separate oil transfer pump, and mixture between the lubricating fluid and high pressure working fluid. Various piston configurations in the working fluid region may also be used to improve piston sealing.