Abstract: A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted graft or vessel via an introducer sheath. When deployed, the basket will automatically conform to the inner dimensions of the vessel lumen. The rotating basket is slowly withdrawn through the clotted graft, mechanically fragmenting the clot. The fragmented, homogenized debris can be flushed into the venous system or aspirated.

Abstract: A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted graft or vessel via an introducer sheath. When deployed, the basket will automatically conform to the inner dimensions of the vessel lumen. The rotating basket is slowly withdrawn through the clotted graft, mechanically fragmenting the clot. The fragmented, homogenized debris can be flushed into the venous system or aspirated.

Abstract: A device and methods for filtering blood clot particles from blood from patient undergoing treatment for a thrombotic condition with a catheter are described. The device comprises a housing having a first end defining a fluid port, an opposite end defining a suction port, and a valve member disposed between the fluid port and the reservoir. The valve member has a semipermeable membrane portion permeable to blood but impermeable to blood clot particles and a one way valve portion having an open position permitting passage of fluid and particles from the fluid port to the reservoir and a closed position blocking passage of particles between the reservoir and the fluid port.

Abstract: A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted graft or vessel via an introducer sheath. When deployed, the basket will automatically conform to the inner dimensions of the vessel lumen. The rotating basket is slowly withdrawn through the clotted graft, mechanically fragmenting the clot. The fragmented, homogenized debris can be flushed into the venous system or aspirated.

Abstract: A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted graft or vessel via an introducer sheath. When deployed, the basket will automatically conform to the inner dimensions of the vessel lumen. The rotating basket is slowly withdrawn through the clotted graft, mechanically fragmenting the clot. The fragmented, homogenized debris can be flushed into the venous system or aspirated.

Abstract: A guide catheter includes a body and a centering mechanism. The body has an elongatable section and a lumen with a stop. The centering mechanism is a plurality of bias elements that forms a self-expanding basket attached to the body so that the elongatable section is within the basket. A straightening catheter engages the stop to stretch the elongatable section and to flatten the basket against the body. The guide catheter can be inserted into a vessel and the centering mechanism can be positioned at a desired treatment site by means of an over-the-wire guidewire system. The straightening catheter can be removed to allow the self-expanding basket to center the guide catheter in the vessel. A dosing device can then be inserted into the guide catheter and located at the centered basket to deliver the brachytherapy to prevent restenosis.

Abstract: A percutaneous thrombolytic device, also referred to herein as a percutaneous mechanical fragmentation catheter system, that includes a wire cage or basket attached to a rotational drive motor. The fragmentation basket, ensheathed in an outer catheter, is introduced into the clotted graft or vessel via an introducer sheath. When deployed, the basket will automatically conform to the inner dimensions of the vessel lumen. The rotating basket is slowly withdrawn through the clotted graft, mechanically fragmenting the clot. The fragmented, homogenized debris can be flushed into the venous system or aspirated.

Abstract: A percutaneous stent-graft is disclosed for restoring blood flow between vessels. The stent-graft has a body implantable device and first and second retaining elements. Also disclosed are methods for deploying a stent-graft.

Abstract: A catheter assembly comprising a needle received within a catheter. The needle has a solid tip and a hole in the cylindrical wall of the needle that communicates with the internal passageway of the needle. The needle is received within the lumen of the catheter, the catheter having a hole in its side wall that aligns with the side hole of the needle. Alignment of the side holes is provided by complementary alignment features on the proximal ends of the needle and catheter. The needle may be connected to a flash chamber for observation of fluid from the cavity. Fluid does not flow into the needle without first entering the side hole of the catheter. Observation of fluid in the flash chamber will not occur until the side hole of the catheter contacts the fluid. This side entrance provides positive indication that the distal end of the catheter has entered the cavity.

Abstract: A percutaneous stent-graft is disclosed for restoring blood flow between vessels. The stent-graft has a body implantable device and first and second peel-away retaining elements. Also disclosed are methods for deploying a stent-graft.