Abstract: A polymer synthesizer is disclosed which has a base on which sits a synthesis case, a synthesis block, and a means of moving the synthesis block and supports for a reagent shelf. The synthesis case has a loading station, drain station, and a water tolerant reagent area and a water sensitive reagent dispensing area. The synthesis case has a cover, a first and a second side, a first and a second end, and a bottom side which contacts the base. The bottom side of the synthesis case has a top face in which there are tracks. A synthesis block moves back and forth in the synthesis case and has a top face and an opening in the top face for a synthesis plate with a plurality of wells. The synthesis block also has a collection area under the synthesis plate to drain spent reagents or optionally hold a sample plate. The polymer synthesizer also has a means of moving the synthesis block back and forth in the synthesis case, preferably a pulley, cable and motor.

Abstract: The present invention is directed to a microcentrifuge apparatus adapted to simultaneously spin a plurality of samples contained within a plurality of rotors. The microcentrifuge comprises an upper plate that has a plurality of upper plate holes; and a lower plate that has a plurality of lower plate holes or recesses. The lower plate is adjacent and substantially parallel to the upper plate, and the plurality of lower plate holes or recesses are in axial alignment with the plurality of upper plate holes. The plurality of rotors are adapted for retaining and spinning the plurality of samples, and are positioned between the upper plate and the lower plate. Each of the plurality of rotors has at opposing ends an upper shaft and a lower shaft, wherein the upper shaft engages one of the upper plate holes and the lower shaft engages one of the lower plate holes or recesses such that the axes of rotation of each of the plurality rotors are substantially perpendicular to the upper and lower plates.

Abstract: A new centrifuge filter is designed for use in an arrayable micro-centrifuge. The filter has an upstream end where fluid enters the filter, an opposite or downstream end, and sides where fluid exits by centrifugal force. The filter is a piece of semipermeable material which is capable of letting certain fluids and small molecules pass therethrough and retaining macromolecules and particles. Also disclosed is an optional support for the filter.

Abstract: The present invention is directed to a microcentrifuge apparatus adapted to simultaneously spin a plurality of samples contained within a plurality of rotors. The microcentrifuge comprises an upper plate that has a plurality of upper plate holes; and a lower plate that has a plurality of lower plate holes or recesses. The lower plate is adjacent and substantially parallel to the upper plate, and the plurality of lower plate holes or recesses are in axial alignment with the plurality of upper plate holes. The plurality of rotors are adapted for retaining and spinning the plurality of samples, and are positioned between the upper plate and the lower plate. Each of the plurality of rotors has at opposing ends an upper shaft and a lower shaft, wherein the upper shaft engages one of the upper plate holes and the lower shaft engages one of the lower plate holes or recesses such that the axes of rotation of each of the plurality rotors are substantially perpendicular to the upper and lower plates.

Abstract: A micropipetter a plurality of hollow needles to deliver fluid, the needles being anchored in a sample block; a needle guide assembly with a plurality of needle guide shafts and compression springs attached at one end to the sample block and at the other end to a needle guide plate, each spring surrounding a needle guide shaft, and the needle guide plate controlling the spacing of the needles; a sample block having a plurality of hollow, tapered spaces, each of which connect with the hollow needle; a displacement volume block having a plurality of hollow spaces, each being occupied by a piston pin, each piston pin being sealed with a stationary seal assembly; a stationary sheet seal located between the sample block and the displacement volume block, the sheet seal having a plurality of holes corresponding to and separating the spaces in the sample block and the displacement volume block, such that precise volume displacement is provided; a seal constraint plate located above the displacement volume block, the

Abstract: A microcentrifuge apparatus has a plurality of rotors for simultaneously spinning a plurality of samples; a retainer for retaining each of the rotors on a bearing surface; and at least one source of motive power, coupled to the rotors by a coupling means, for causing each of the rotors to spin at substantially the same rate. The source of motive power can be a motor, engine, or electromagnetic power. The coupling means can be a drive belt, gears, or friction drive. Another embodiment of the microcentrifuge has a plurality of disposable rotors for simultaneously spinning a plurality of samples; a retainer for retaining each of the rotors on a bearing surface; and a source of motive power, coupled to the rotors, causing each of the rotors to spin at substantially the same rate.

Abstract: A thermocycling apparatus comprising a plurality of capillaries for moving DNA-containing samples between two or more discrete zones maintained at selected elevated temperatures.

Abstract: A thermocycling apparatus comprising a plurality of capillaries for moving DNA-containing samples between two or more discrete zones maintained at selected elevated temperatures.

Abstract: Apparatus and method for producing a defined size distribution of polynucleotide fragments having a selected mean size range between about 100 and 20,000 base pairs. The method includes passing a suspension of polynucleotide fragments through an apparatus containing a capillary with an orifice near the outlet end of the capillary.