Patents by Inventor Scott P. Runyon

Scott P. Runyon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL DERIVATIVES AS APELIN RECEPTOR AGONISTS
    Publication number: 20240174638
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: February 15, 2022
    Publication date: May 30, 2024
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN
  • Heterocyclic apelin receptor (APJ) agonists and uses thereof
    Patent number: 11926612
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 12, 2024
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, Kenneth S. Rehder
  • INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
    Publication number: 20230339863
    Abstract: The present disclosure includes peripheral partial agonists of one or more CB receptors, including modulation of CB1, both with and without CB2 selectivity. The compounds of the present disclosure may be useful in the treatment of diseases and disorders mediated by a CB-signaling pathway, including but not limited to pain, gastrointestinal disorders, metabolic disorders, and liver disorders, such as alcoholic steatohepatitis or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: January 29, 2021
    Publication date: October 26, 2023
    Inventors: George AMATO, Rangan MAITRA, Scott P. RUNYON
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11535630
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: December 27, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • METHODS AND USES FOR APELIN RECEPTOR AGONISTS
    Publication number: 20220280483
    Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 8, 2022
    Inventors: Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER, Scott P. RUNYON
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11401244
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: August 2, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Substituted 1,2,3,4-tetrahydroisoquinolines as kappa opioid antagonists
    Patent number: 11292783
    Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 5, 2022
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Chad M. Kormos, Pauline W. Ondachi, Scott P. Runyon, Hernan A. Navarro, James B. Thomas, S. Wayne Mascarella
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11267789
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: March 8, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10954247
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 23, 2021
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20210070767
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 11, 2021
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20190322644
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Application
    Filed: October 11, 2017
    Publication date: October 24, 2019
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20190315693
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 17, 2019
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS
  • Tetrahydroisoquinoline Kappa Opioid Antagonists
    Publication number: 20190263781
    Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 29, 2019
    Applicant: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Chad M. Kormos, Pauline W. Ondachi, Scott P. Runyon, Hernan A. Navarro, James B. Thomas, S. Wayne Mascarella
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10377718
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 13, 2019
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10100059
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 16, 2018
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
    Patent number: 10087211
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 2, 2018
    Assignees: RESEARCH TRIANGLE INSTITUTE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20180265518
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • Arylpiperazine opioid receptor antagonists
    Patent number: 9750738
    Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: September 5, 2017
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Frank Ivy Carroll, Juan P. Cueva, James B. Thomas, S. Wayne Mascarella, Scott P. Runyon
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20170166577
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: RE49594
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: August 1, 2023
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu