Patents by Inventor Scott R. Gilbertson

Scott R. Gilbertson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS
    Publication number: 20230124492
    Abstract: In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Application
    Filed: December 10, 2020
    Publication date: April 20, 2023
    Inventors: Cynthia V. Pagba, Alemayehu Gorfe Abebe, Scott R. Gilbertson, Kasuni Dilsha
  • 5-HTR agonist analogs
    Patent number: 10544152
    Abstract: The invention relates to the novel analogs of selective 5HT2CR agonist WAY163909, the preparation, and the use thereof.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: January 28, 2020
    Assignees: The Board of Regents of The University of Texas System, University of Houston System
    Inventors: Kathryn A. Cunningham, Scott R. Gilbertson
  • NOVEL 5-HT2CR AGONIST ANALOGS
    Publication number: 20190031672
    Abstract: The invention relates to the novel analogs of selective 5HT2CR agonist WAY163909, the preparation, and the use thereof.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 31, 2019
    Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, University of Houston System
    Inventors: Kathryn A. Cunningham, Scott R. Gilbertson
  • Substrate peptide sequences for plague plasminogen activator and uses thereof
    Patent number: 9187523
    Abstract: The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: November 17, 2015
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Vladimir L. Motin, Sadhana Chauhan, Scott R. Gilbertson, Anton Agarkov, Pedro Lory
  • Substrate peptide sequences for plague plasminogen activator and uses thereof
    Publication number: 20120045474
    Abstract: The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
    Type: Application
    Filed: August 29, 2011
    Publication date: February 23, 2012
    Inventors: Vladimir L. Motin, Sadhana Chauhan, Scott R. Gilbertson, Anton Agarkov, Pedro Lory
  • METHODS AND COMPOSITIONS TO INHIBIT EDEMA FACTOR AND ADENYLYL CYCLASE
    Publication number: 20120010233
    Abstract: Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3?,5?-adenosine monophosphate. Specific compositions of the invention are also novel.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 12, 2012
    Applicants: Board of Regents, The University of Texas, Mission Pharmacal Co.
    Inventors: Catherine H. Schein, Scott R. Gilbertson, Johnny W. Peterson, Deliang Chen, Maria Esterlla-Jimenez, Mary A. Walter, Jian Gao
  • Substrate peptide sequences for plague plasminogen activator and uses thereof
    Patent number: 8030447
    Abstract: The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: October 4, 2011
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Vladimir L. Motin, Sadhana Chauhan, Scott R. Gilbertson, Anton Agarkov, Pedro Lory
  • Methods and compositions to inhibit edema factor and adenylyl cyclase
    Patent number: 8003692
    Abstract: Fluorene-based molecules and their derivatives are described in compositions for the treatment of intestinal fluid loss.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: August 23, 2011
    Assignees: Board of Regents, The University of Texas System, Mission Pharmacal Co.
    Inventors: Catherine H. Schein, Johnny W. Peterson, Scott R. Gilbertson, Deliang Chen, Maria Estrella-Jimenez, Mary A. Walter, Jian Gao
  • Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase
    Publication number: 20090093519
    Abstract: Small molecules and their derivatives are described for the treatment and/or prevention of intestinal fluid loss. Also disclosed are methods of using said molecules and their derivatives to treat and/or prevent conditions associated with increased levels of 3?,5?-adenosine monophosphate. Specific compositions of the invention are also novel.
    Type: Application
    Filed: June 13, 2008
    Publication date: April 9, 2009
    Applicants: Mission Pharmacal Co., Board of Regents, The University of Texas System
    Inventors: Catherine H. Schein, Scott R. Gilbertson, Johnny W. Peterson, Deliang Chen, Maria Estrella-Jimenez, Mary A. Walter, Jian Gao
  • Substrate peptide sequences for plague plasminogen activator and uses thereof
    Publication number: 20090069248
    Abstract: The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 12, 2009
    Inventors: Vladimir L. Motin, Sadhana Chauhan, Scott R. Gilbertson, Anton Agarkov, Pedro Lory
  • Phosphine containing amino acids and peptides and methods of preparing and using same
    Patent number: 5541289
    Abstract: A method for incorporating novel phosphine containing amino acids into peptide sequences is provided. The resulting phosphine-containing peptides can be used to bind a transition metal between two phosphine moieties presented on an amino acid in a peptide. The resulting phosphine-containing peptide metal complex is useful as a stereoselective catalyst of a chemical reaction or as a means for delivering a metal selectively to a target tissue or organ for medical uses.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: July 30, 1996
    Assignee: Washington University
    Inventor: Scott R. Gilbertson