Abstract: Disclosed herein are system, method, and computer program product embodiments for managing and tracking the deployment of a cloud control within a cloud network where creation of the cloud control may be distributed between different user devices in the cloud network. A cloud control is implemented using a control policy which is composed of one or more components that provide functions for executing a functionality of the cloud control. A component workflow manager delegates control of the one or more components to different user devices and tracks the development workflow of the components as they progress through workflow states until they are ready for deployment within the cloud network.

Abstract: An exemplary automated system and method are provided for monitoring and controlling the transfer of water to water tanks or containers during a water transfer process. In one embodiment, the automated system includes a first manifold, a plurality of controllable valves, a plurality of level indicators, a pump, controller(s), storage device, and display. In one implementation, the controller is configured to control the opening/closing of the plurality of controllable valves based, at least in part, on the water levels of the frac water tanks. The controller(s) may include one or more control modes. In other implementations, the system may include a second manifold (or additional manifolds) and the capability to blend water from two or more sources, such as from an impaired water source, using either a single or multiple-manifold configuration. In other implementations, an assembly is provided, such as a skid or trailer mounted assembly, for use in a mobile automated system.

Abstract: A wearable injector for automated delivery of biologic drugs that solves the problem of high volume and high viscosity drug administration by providing a device that can be worn by the patient through use of an adhesive patch to deliver the medication slowly over extended periods of time.

Abstract: A wearable injector for automated delivery of biologic drugs that solves the problem of high volume and high viscosity drug administration by providing a device that can be worn by the patient through use of an adhesive patch to deliver the medication slowly over extended periods of time.

Abstract: Needle assemblies for retractable needle syringes include a needle, a needle seal, and a needle retainer, wherein the needle includes one or more barbs substantially at its proximal end. The needle retainer engages an optional needle-over-mold component that is fixedly attached to the needle. The needle-over-mold may be connected to the distal surface of the needle seal and may travel, such as by being a couple component, with the needle during the operation of the syringe. A safety syringe includes a barrel having a needle assembly mounted at a distal end and a plunger assembly mounted at a proximal end. A drug may be contained in a drug chamber of barrel, between the plunger assembly and needle assembly, proximally of the needle seal for drug delivery to a user. The plunger assembly includes a plunger seal having a needle-engaging portion to capture the needle at the barb for retraction.

Abstract: An expanding plunger rod (100) for a syringe (50). The expanding plunger rod is configured to transition from a packaged configuration for packaging to an expanded configuration for operation. The expanding plunger rod comprises a substantially cylindrical outer sleeve (110) having a closed-off bottom end (108) and an open upper end (111). The expanding plunger includes an inner rod (114) having a lower end (138) and an upper end (140). The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod is configured to lock axially in place so as to prevent transition from the expanded configuration to the packaged configuration.

Abstract: The present invention provides orexin receptor antagonists for use in treating aggression in a subject. The orexin receptor antagonists can have selective affinity for orexin receptor 1 (Ox1R) or for orexin receptor 2 (Ox2). The orexin receptor antagonists can also have dual affinity for both Ox1R and Ox2R, wherein their affinities can be the same or different. The present invention also provides pharmaceutical compositions and kits comprising orexin receptor antagonists for treating aggression or for treating psychiatric disorders with an aggression component.

Abstract: An exemplary automated system and method are provided for monitoring and controlling the transfer of water to water tanks or containers during a water transfer process. In one embodiment, the automated system includes a first manifold, a plurality of controllable valves, a plurality of level indicators, a pump, controller(s), storage device, and display. In one implementation, the controller is configured to control the opening/closing of the plurality of controllable valves based, at least in part, on the water levels of the frac water tanks. The controller(s) may include one or more control modes. In other implementations, the system may include a second manifold (or additional manifolds) and the capability to blend water from two or more sources, such as from an impaired water source, using either a single or multiple-manifold configuration. In other implementations, an assembly is provided, such as a skid or trailer mounted assembly, for use in a mobile automated system.

Abstract: An expanding plunger rod (100) for a syringe (50). The expanding plunger rod is configured to transition from a packaged configuration for packaging to an expanded configuration for operation. The expanding plunger rod comprises a substantially cylindrical outer sleeve (110) having a closed-off bottom end (108) and an open upper end (111). The expanding plunger includes an inner rod (114) having a lower end (138) and an upper end (140). The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod is configured to lock axially in place so as to prevent transition from the expanded configuration to the packaged configuration.

Abstract: An exemplary automated system and method are provided for monitoring and controlling the transfer of water to frac water tanks during hydraulic fracturing. In one embodiment, the automated system includes a first manifold, a plurality of controllable valves, a plurality of level indicators, a pump, controller(s), storage device, and display. In one implementation, the controller is configured to control the opening/closing of the plurality of controllable valves based, at least in part, on the water levels of the frac water tanks. The controller(s) may include one or more control modes. In other implementations, the system may include a second manifold (or additional manifolds) and the capability to blend water from two or more sources, such as from an impaired water source, using either a single or multiple-manifold configuration. In other implementations, an assembly is provided, such as a skid or trailer mounted assembly, for use in a mobile automated system.

Abstract: One general aspect includes a cap for a the overflow reservoir bottle, including a lower cup having a syncline void, said syncline void having by a wall extending above and below at least one surface of the lower cup. The cap also includes an upper cup with an anticline projection nesting adjacent to the syncline void of the lower cup, and said upper cup affixed to the lower cup, with at least one vent to permit gas to traverse the overflow reservoir bottle.

Abstract: A vial adapter is provided for interconnecting a vial having a closure and a fluid delivery device such as a safety syringe. The vial adapter comprises an adapter housing having a base, a shroud extending or projecting from the base and a cannula extending or projecting from the base for penetrating a rubber seal on the vial closure to thereby establish fluid communication between the vial and the vial adapter. The shroud may comprise a plurality of latitudinal slits or windows within each of which resides a flexion arm connected to the shroud, each flexion arm capable of engaging and/or retaining vial closures of any of a variety of different sizes. The vial adapter may comprise a conduit tip in fluid communication with the cannula to allow transfer of fluid to or from the safety syringe while also preventing inadvertent activation of a safety syringe needle retraction mechanism.

Abstract: An expanding plunger rod for a syringe is configured to transition from a packaged configuration to an expanded configuration for operation. The rod includes a substantially cylindrical outer sleeve having a closed-off bottom end and an open upper end, and an inner rod having a lower end and an upper end. The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod locks axially in place to prevent transition from the expanded to the packaged configuration.

Abstract: A barrel adapter for a syringe having a barrel and plunger. The adapter comprises a barrel tip and a needle retraction mechanism having a needle subassembly with a needle and a lumen, actuator subassembly, and biasing member. The needle subassembly moves from an injection to a retracted position within the barrel tip. The actuator subassembly includes a retainer connected to the barrel tip, a stylet held in a stylet disc, and a prong passing into the retainer. The stylet slides within the needle lumen and is spaced from the needle tip in the injection position. The biasing member biases the NOM from the retainer. A locking arrangement compresses the biasing member when locked and releases the biasing member when actuated by depression of the plunger, which moves the prong against the retainer. The biasing member moves the needle and stylet from the injection position to the retracted position when released.

Abstract: The present embodiments provide for a syringe and a retraction plunger assembly configured to accept various retractable needle assemblies, which are capable of cooperating to provide a retraction safety syringe. In particular, the syringe includes a barrel and a retraction plunger assembly comprising a control unit attached to a plunger and releasably engaged to a housing, and at least one biasing means disposed within the plunger assembly. Upon completion of dose delivery via a retractable needle, the control unit disengages from housing and the biasing member retracts the plunger and a connected needle into the barrel. Various elements are configured to prevent further use of the syringe. The control unit can be used to control a rate of needle retraction.

Abstract: An exemplary automated system and method are provided for monitoring and controlling the transfer of water to frac water tanks during hydraulic fracturing. In one embodiment, the automated system includes a first manifold, a plurality of controllable valves, a plurality of level indicators, a pump, controller(s), storage device, and display. In one implementation, the controller is configured to control the opening/closing of the plurality of controllable valves based, at least in part, on the water levels of the frac water tanks. The controller(s) may include one or more control modes. In other implementations, the system may include a second manifold (or additional manifolds) and the capability to blend water from two or more sources, such as from an impaired water source, using either a single or multiple-manifold configuration. In other implementations, an assembly is provided, such as a skid or trailer mounted assembly, for use in a mobile automated system.

Abstract: One general aspect includes a cap for a the overflow reservoir bottle, including a lower cup having a syncline void, said syncline void having by a wall extending above and below at least one surface of the lower cup. The cap also includes an upper cup with an anticline projection nesting adjacent to the syncline void of the lower cup, and said upper cup affixed to the lower cup, with at least one vent to permit gas to traverse the overflow reservoir bottle.

Abstract: Barrel adapters for safety syringes include a barrel and a plunger assembly adapted to move within the barrel, a barrel tip adapted to be sealingly engaged with a distal end of the barrel and a needle retraction mechanism barrel having a needle subassembly and an actuator subassembly. The needle subassembly includes a needle, and a needle-over-mold (NOM) through which the needle extends. The needle subassembly is disposed at least partially within the barrel tip, and adapted to move from an injection position in which the needle extends from a distal end of the barrel tip to a retracted position in which the needle is disposed within at least one of the barrel tip or the barrel. The actuator subassembly includes a needle seal, a push-bar, and an actuator surface. The needle retraction mechanism barrel includes a biasing member and an actuable locking arrangement. A syringe includes such barrel adapters.

Abstract: An expanding plunger rod for a syringe is configured to transition from a packaged configuration to an expanded configuration for operation. The rod includes a substantially cylindrical outer sleeve having a closed-off bottom end and an open upper end, and an inner rod having a lower end and an upper end. The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod locks axially in place to prevent transition from the expanded to the packaged configuration.

Abstract: The present embodiments provide for a syringe and a retraction plunger assembly configured to accept various retractable needle assemblies, which are capable of cooperating to provide a retraction safety syringe. In particular, the syringe includes a barrel and a retraction plunger assembly comprising a control unit attached to a plunger and releasably engaged to a housing, and at least one biasing means disposed within the plunger assembly. Upon completion of dose delivery via a retractable needle, the control unit disengages from housing and the biasing member retracts the plunger and a connected needle into the barrel. Various elements are configured to prevent further use of the syringe. The control unit can be used to control a rate of needle retraction.