Patents by Inventor Scott T. Younger

Scott T. Younger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATING GENE EXPRESSION WITH agRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS
    Publication number: 20150064709
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: September 10, 2014
    Publication date: March 5, 2015
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jacob C. SCHWARTZ, Scott T. YOUNGER, Bethany A. JANOWSKI, David R. COREY
  • Modulating Gene Expression With agRNA and Gapmers Targeting Antisense Transcripts
    Publication number: 20120288869
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: July 3, 2012
    Publication date: November 15, 2012
    Inventors: Jacob C. Schwartz, Scott T. Younger, Bethany A. Janowski, David R. Corey
  • Modulation of gene expression through endogenous small RNA targeting of gene promoters
    Patent number: 8222221
    Abstract: Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: July 17, 2012
    Assignee: The Board of Regents of the University of Texas System
    Inventors: David R. Corey, Scott T. Younger
  • Modulation of gene expression through endogenous small RNA targeting of gene promoters
    Publication number: 20090326051
    Abstract: Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 31, 2009
    Inventors: David R. Corey, Scott T. Younger
  • Modulating Gene Expression with agRNA and Gapmers Targeting Antisense Transcripts
    Publication number: 20090092988
    Abstract: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
    Type: Application
    Filed: October 6, 2008
    Publication date: April 9, 2009
    Inventors: Jacob C. Schwartz, Scott T. Younger, Bethany A. Janowski, David R. Corey