Patents by Inventor Scott Wilbur
Scott Wilbur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230131121Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.Type: ApplicationFiled: May 27, 2022Publication date: April 27, 2023Inventors: Paul D. DAVIS, D. Scott WILBUR
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Patent number: 11505525Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.Type: GrantFiled: June 23, 2017Date of Patent: November 22, 2022Assignees: Quanta BioDesign, Ltd., University of WashingtonInventors: Paul D. Davis, D. Scott Wilbur
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Publication number: 20220354974Abstract: Reagents and methods for labeling biomolecules with astatine isotopes in higher oxidation states. The reagents and methods allow for efficient labeling of biomolecules, such as antibodies, without the formation of high molecular weight by products that arise due to 211At-promoted dimerization and higher aggregation of the conjugated biomolecules, and diminish cellular retention of astatine caused by cellular oxidization of the bonded astatine atom in vivo.Type: ApplicationFiled: April 26, 2022Publication date: November 10, 2022Applicant: University of WashingtonInventors: D. Scott Wilbur, Ming-Kuan Chyan, Donald K. Hamlin
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Publication number: 20200317612Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.Type: ApplicationFiled: October 10, 2019Publication date: October 8, 2020Applicants: Quanta BioDesign, Ltd, University of WashingtonInventors: Paul D. Davis, D. Scott Wilbur
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Publication number: 20170313656Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.Type: ApplicationFiled: June 23, 2017Publication date: November 2, 2017Inventors: Paul D. Davis, D. Scott Wilbur
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Publication number: 20160053345Abstract: This disclosure relates to methods for purifying and isolating astatine-211 from bismuth metal. Also disclosed are automated methods for purifying and isolating astatine-211 from bismuth metal.Type: ApplicationFiled: August 21, 2015Publication date: February 25, 2016Inventors: D. Scott Wilbur, Ming-Kuan Chyan, Donald K. Hamlin, Katherine Gagnon, Shigeki Watanabe
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Patent number: 8951499Abstract: A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.Type: GrantFiled: September 6, 2006Date of Patent: February 10, 2015Assignees: University of Washington, Glycorex Transplantation ABInventors: D. Scott Wilbur, Bengt E. B. Sandberg
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Publication number: 20140179877Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.Type: ApplicationFiled: July 18, 2013Publication date: June 26, 2014Inventors: Rune NILSSON, Bengt SANDBERG, Scott WILBUR
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Patent number: 8586177Abstract: Structural damage repair elements including inserts and a structural damage repair kit is provided. The structural damage repair elements typically include two or more layers of materials having an adhesive therebetween that are subsequently compressed together. The structural damage repair kit includes a chemical molding agent, an optional jig, one or more structural damage repair elements and a sealant. Both hollow and solid elongated objects, as well as relatively flat, curved objects may be repaired with the kit. The structural damage repair elements include rods, wafers, and/or adhesive saturated inserts.Type: GrantFiled: September 24, 2009Date of Patent: November 19, 2013Assignee: Scoda America, Inc.Inventors: Wesley Scott Wilbur, David Kip Wilbur
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Patent number: 8480503Abstract: A bowling ball with an indicia is provided. A method for manufacturing such a bowling ball is also provided. The indicia may be preformed and attached to the core of the bowling ball before the outer layer of the bowling ball is created.Type: GrantFiled: June 14, 2012Date of Patent: July 9, 2013Assignee: Scoda America, Inc.Inventors: W. Scott Wilbur, David Wilbur, Harold Thommen, III, Kevin Keck
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Publication number: 20130052130Abstract: Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.Type: ApplicationFiled: August 30, 2012Publication date: February 28, 2013Applicants: UNIVERSITY OF WASHINGTON, QUANTA BIODESIGN, LTD.Inventors: Paul D. Davis, D. Scott Wilbur
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Publication number: 20120252593Abstract: A bowling ball with an indicia is provided. A method for manufacturing such a bowling ball is also provided. The indicia may be preformed and attached to the core of the bowling ball before the outer layer of the bowling ball is created.Type: ApplicationFiled: June 14, 2012Publication date: October 4, 2012Inventors: W. Scott WILBUR, David Wilbur, Harold Thommen, III, Kevin Keck
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Patent number: 8221252Abstract: A bowling ball with an indicia is provided. A method for manufacturing such a bowling ball is also provided. The indicia may be preformed and attached to the core of the bowling ball before the outer layer of the bowling ball is created.Type: GrantFiled: March 12, 2009Date of Patent: July 17, 2012Assignee: Scoda America, Inc.Inventors: W. Scott Wilbur, David Wilbur, Harold Thommen, III, Kevin Keck
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Patent number: 8124364Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.Type: GrantFiled: June 18, 2001Date of Patent: February 28, 2012Assignee: Glycorex Transplantation ABInventors: Bengt Sandberg, Scott Wilbur, Rune Nilsson
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Publication number: 20110014151Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.Type: ApplicationFiled: January 11, 2007Publication date: January 20, 2011Applicant: Biotech IgG ABInventors: Rune Nilsson, Bengt Sandberg, Scott Wilbur
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Publication number: 20100012257Abstract: Structural damage repair elements including inserts and a structural damage repair kit is provided. The structural damage repair elements typically include two or more layers of materials having an adhesive therebetween that are subsequently compressed together. The structural damage repair kit includes a chemical molding agent, an optional jig, one or more structural damage repair elements and a sealant. Both hollow and solid elongated objects, as well as relatively flat, curved objects may be repaired with the kit. The structural damage repair elements include rods, wafers, and/or adhesive saturated inserts.Type: ApplicationFiled: September 24, 2009Publication date: January 21, 2010Inventors: Wesley Scott Wilbur, David Kip Wilbur
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Publication number: 20090309255Abstract: A bowling ball with an indicia is provided. A method for manufacturing such a bowling ball is also provided. The indicia may be preformed and attached to the core of the bowling ball before the outer layer of the bowling ball is created.Type: ApplicationFiled: March 12, 2009Publication date: December 17, 2009Inventors: W. Scott Wilbur, David Wilbur, Harold Thommen, III, Kevin Keck
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Patent number: 7615129Abstract: Structural damage repair elements including inserts and a structural damage repair kit is provided. The structural damage repair elements typically include two or more layers of materials having an adhesive therebetween that are subsequently compressed together. The structural damage repair kit includes a chemical molding agent, an optional jig, one or more structural damage repair elements and a sealant. Both hollow and solid elongated objects, as well as relatively flat, curved objects may be repaired with the kit. The structural damage repair elements include rods, wafers, and/or adhesive saturated inserts.Type: GrantFiled: December 23, 2005Date of Patent: November 10, 2009Assignee: Scoda America, Inc.Inventors: Wesley Scott Wilbur, David Kip Wilbur
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Patent number: 7141676Abstract: Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water-soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds also are disclosed.Type: GrantFiled: September 30, 2002Date of Patent: November 28, 2006Assignee: University of WashingtonInventors: D. Scott Wilbur, Pradip M. Pathare, Donald K. Hamlin, Feng Wan
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Publication number: 20040052784Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.Type: ApplicationFiled: April 23, 2003Publication date: March 18, 2004Inventors: Bengt Sandberg, Scott Wilbur, Rune Nilsson