Abstract: This disclosure provides compositions and methods for treating or preventing neuronal injury in a subject, e.g., a subject at risk of or having traumatic brain injury or stroke.

Abstract: This disclosure provides compositions and methods for treating or preventing liver diseases and disorders with hyperammonemia or muscle wasting in a subject.

Abstract: Disclosed is a clip for attaching one or more transducers, such as arterial blood pressure transducers, to a variety of different objects. The clip typically includes first and second arms that are pivotally connected together. The clip also typically includes an alignment device that facilitates the alignment of the clip with a patient. The clip is configured to be movable between (i) a first orientation to place an object with an attachment location and (ii) a second orientation to secure the object within the attachment location. In some instances, the attachment location is rotatable relative to the clip.

Abstract: An apparatus for generating electrical power downhole comprises a housing located in a drillstring. A primary flow channel is formed through the housing. At least two secondary flow channels are located in the housing and arc laterally displaced from the primary flow channel, A fluid driven electrical generator is positioned in each of the at least two secondary flow channels. A controllable flow diverter is associated with each of the secondary flow channels to controllably divert at least a portion of a fluid flow m the primary flow channel to at least one of the at least two secondary flow channels to drive the generator therein.

Abstract: Disclosed herein are methods and compositions for using nanoexpression to interrogate antigen specificity within antibody repertoires. Also disclosed herein is an antibody display system composition comprising one or more recombinant nucleic acid sequences comprising a first nucleic acid sequence encoding a heavy chain variable region sequence or fragment thereof operatively linked to a first identification region sequence and a second nucleic acid sequence encoding a light chain variable region sequence or fragment thereof operatively linked to a second identification region sequence.

Abstract: A prescription verification system and method is provided that stores and processes information on one or more servers for verifying medical prescription orders originating from healthcare providers. The system and method enables one or more clients to retrieve medical prescriptions and for ordering personnel information for prescription verification through the system. The system includes functionality for entering, editing, or deleting data files and retrieving and displaying them as requested by authorized users as they pertain to ordering, verifying, filling and tracking of medical prescriptions.

Abstract: An apparatus for generating electrical power downhole comprises a housing located in a drillstring. A primary flow channel is formed through the housing. At least two secondary flow channels are located in the housing and arc laterally displaced from the primary flow channel, A fluid driven electrical generator is positioned in each of the at least two secondary flow channels. A controllable flow diverter is associated with each of the secondary flow channels to controllably divert at least a portion of a fluid flow m the primary flow channel to at least one of the at least two secondary flow channels to drive the generator therein.

Abstract: A well tool can include sealing surfaces, and a shape memory material seal which dynamically seals between the sealing surfaces with metal-to-metal contact between the shape memory material seal and each of the sealing surfaces. A method of sealing in a well tool can include forming a shape memory material seal, heat treating the seal, then deforming the seal, then installing the seal in the well tool, and then heating the seal, thereby causing the seal to expand into metal-to-metal sealing contact with a sealing surface which displaces relative to the shape memory material seal. A drill bit can include sealing surfaces formed on a cone and a journal of the drill bit, and a shape memory material seal which dynamically seals between the sealing surfaces with metal-to-metal contact between the shape memory material seal and each of the sealing surfaces.

Abstract: A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation tool is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.

Abstract: A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Abstract: A catheter adapted for mapping and ablating epicardial tissue from the pericardial cavity includes a catheter body and an electrode assembly that has a tip section and a loop member lying generally within a plane, wherein the tip section includes an ablation electrode exposed on one side of the loop member and an insulation member exposed on an opposite side of the loop member. The catheter also includes a intermediate section between the catheter body and the electrode assembly, wherein the intermediate deflects the loop member and the tip section bi-directionally within the same plane. So arranged, the catheter can be safely maneuvered in the pericardial sac and swept in a side to side motion over the epicardium with the ablation electrode reliably facing and making contact with the epicardium. The tip section can include a balloon that is inflatable to push away surrounding pericardial tissue.

Abstract: A centralized verification system and method is provided that stores and processes information on a secure remote server database for verifying medical prescription orders originating from healthcare providers. A secure interactive website resides on a remote server with a unique URL address, enabling one or more clients to retrieve medical prescriptions originated and for ordering personnel information for prescription verification through the internet by use of a general purpose computer. Access is limited to medical and pharmacy personnel having a validated and authorized identification and access code. The system includes functionality for entering, editing, or deleting data files and retrieving and displaying them as requested by authorized users as they pertain to ordering and filling of medical prescriptions.

Abstract: A prescription verification system and method is provided that stores and processes information on one or more servers for verifying medical prescription orders originating from healthcare providers. The system and method enables one or more clients to retrieve medical prescriptions and for ordering personnel information for prescription verification through the system. The system includes functionality for entering, editing, or deleting data files and retrieving and displaying them as requested by authorized users as they pertain to ordering, verifying, filling and tracking of medical prescriptions.

Abstract: A catheter adapted for mapping and ablating epicardial tissue from the pericardial cavity includes a catheter body and an electrode assembly that has a tip section and a loop member lying generally within a plane, wherein the tip section includes an ablation electrode exposed on one side of the loop member and an insulation member exposed on an opposite side of the loop member. The catheter also includes a intermediate section between the catheter body and the electrode assembly, wherein the intermediate deflects the loop member and the tip section bi-directionally within the same plane. So arranged, the catheter can be safely maneuvered in the pericardial sac and swept in a side to side motion over the epicardium with the ablation electrode reliably facing and making contact with the epicardium. The tip section can include a balloon that is inflatable to push away surrounding pericardial tissue.

Abstract: Disclosed is an apparatus and method for communicating over an electrically conductive line having a plurality of power line phases between a first device having a single receiver and plurality of distal devices. The power line phases are adapted to deliver an alternating electrical current. Each of the distal devices are adapted to communicate with the first device over a single phase through a modulated carrier signal at a communication frequency. The apparatus comprises a plurality of unique coupling phases for coupling to a corresponding power line phase adapted to receive a frequency band having the modulated carrier signal from each of the plurality of power line phases and a selective coupling circuit between each of the plurality of coupling phases. The method comprises receiving the modulated carrier signal from each of the plurality of power line phases, attenuating the frequency band from being received by another of said unique coupling phases.

Abstract: A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Abstract: A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Abstract: A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen.

Abstract: A medical device is provided having a means for actuating a pair of opposing jaw members. The jaw members are movable relative to one another from a first position, wherein the jaw members are disposed in a spaced apart relation relative to one another, to a second position, wherein the jaw members cooperate to grasp tissue therebetween. An ablation mechanism is connected to at least one of the jaws members, such that the jaw members are capable of conducting ablation energy through the tissue grasped therebetween.

Abstract: Deflection mechanisms are disclosed that are positionable to deflecting portions of a flexible body, such as a catheter, in more than one direction in a single plane, as well as in more than one plane. The invention allows a distal portion of a catheter to be deflected more than 360 degrees to provide a loop.