Abstract: According to one aspect, an electric toothbrush may include a handle, a brush head, a rechargeable battery, an electric motor, and a pair of electrical contacts. The handle may have a first end region and a second end region defining a longitudinal axis therebetween, the handle defining a volume from the first end region to the second end region. The brush head may include bristles, the brush head releasably securable to the first end region of the handle. The rechargeable battery may be in the volume. The electric motor may be at least partially disposed in the volume, the electric motor in electrical communication with the rechargeable battery, the electric motor in mechanical communication with the brush head. The pair of electrical contacts may be in electrical communication with the rechargeable battery, and the pair of electrical contacts axially and radially spaced from one another, relative to the longitudinal axis.

Abstract: A sail wheel includes a large wheel with a sail that is ridden on an outrigger attached to an axle of the large wheel. The outrigger includes a handle section and a foot stand section, allowing a user to ride and control the sail wheel. The sail wheel utilizes wind power for propulsion and is used on land for extreme sports or recreationally.

Abstract: A method for generating an immune score, the method comprising the steps of: (i) determining a qualitative and/or quantitative assessment of tumor infiltrating lymphocytes in a sample; (ii) determining a qualitative and/or quantitative assessment of T-cell receptor signaling in the sample; (iii) determining a qualitative and/or quantitative assessment of mutation burden in the sample; (iv) generating, using a predictive algorithm, an immune score based on the determined qualitative and/or quantitative assessment of tumor infiltrating lymphocytes, the determined qualitative and/or quantitative assessment of T-cell receptor signaling, and the determined qualitative and/or quantitative assessment of mutation burden.

Abstract: A method for generating an immune score, the method comprising the steps of: (i) determining a qualitative and/or quantitative assessment of tumor infiltrating lymphocytes in a sample; (ii) determining a qualitative and/or quantitative assessment of T-cell receptor signaling in the sample; (iii) determining a qualitative and/or quantitative assessment of mutation burden in the sample; (iv) generating, using a predictive algorithm, an immune score based on the determined qualitative and/or quantitative assessment of tumor infiltrating lymphocytes, the determined qualitative and/or quantitative assessment of T-cell receptor signaling, and the determined qualitative and/or quantitative assessment of mutation burden.

Abstract: A method for characterizing tumor response to immune checkpoint blockade therapy, comprising: (i) obtaining tissue from the tumor; (ii) measuring, using the tissue, expression of one or more cell proliferation gene markers; (iii) determining, based on the measured expression of the one or more cell proliferation gene markers, a proliferation profile of the tumor; (iv) predicting, based on the determined proliferation profile, response of the tumor to immune checkpoint blockade therapy; and (v) determining, by a physician using the predicted response of the tumor to immune checkpoint blockade therapy, a therapy for the tumor.

Abstract: A liner (18) for a shaped-charge (10) that is compressively formed from a mixture of powdered metal, powdered metal binder, and a selected quantity of nanoparticle material, is used to achieve improved penetration depths during perforation of a wellbore. Exemplary nanoparticles include lead, tin, copper, molybdenum, etc. Such nanoparticles increase the density, sound speed, or acoustic impedance of the liner. In another embodiment, the added nanoparticles comprise reactive materials which, after penetration into the formation, cause secondary reactions in the perforations.

Abstract: A method for characterizing tumor response to immune checkpoint blockade therapy, comprising: (i) obtaining tissue from the tumor; (ii) measuring, using the tissue, expression of one or more cell proliferation gene markers; (iii) determining, based on the measured expression of the one or more cell proliferation gene markers, a proliferation profile of the tumor; (iv) predicting, based on the determined proliferation profile, response of the tumor to immune checkpoint blockade therapy; and (v) determining, by a physician using the predicted response of the tumor to immune checkpoint blockade therapy, a therapy for the tumor.

Abstract: A non-destructive inspection method that comprises obtaining one or more images corresponding to an X-ray, scanning electron microscope, or CT scan of an object, assigning numeric values to pixels of the images, comparing the numeric values to reference numeric values, and identifying an anomaly in the object based on the comparison. A non-destructive inspection system that comprises at least one processor, a memory in communication with the processor and storing instructions that causes the processor to obtain an image corresponding to an X-ray, scanning electron microscope, or CT scan of an object, assign numeric values to pixels of the image, compare the assigned numeric values to reference numeric values, and identify an anomaly in the object based on the comparison.

Abstract: A non-destructive inspection method that comprises obtaining one or more images corresponding to an X-ray, scanning electron microscope, or CT scan of an object, assigning numeric values to pixels of the images, comparing the numeric values to reference numeric values, and identifying an anomaly in the object based on the comparison. A non-destructive inspection system that comprises at least one processor, a memory in communication with the processor and storing instructions that causes the processor to obtain an image corresponding to an X-ray, scanning electron microscope, or CT scan of an object, assign numeric values to pixels of the image, compare the assigned numeric values to reference numeric values, and identify an anomaly in the object based on the comparison.

Abstract: A method may include positioning at least one calibration disk in a computed tomography (CT) scanner and positioning a pellet in the CT scanner. The at least one calibration disk and the pellet may both be made of a same powder exhibiting a known density. The method may further include scanning the at least one calibration disk and the pellet using the CT scanner to obtain one or more CT images of the pellet and the at least one calibration disk, and comparing a density of the pellet with the known density of the at least one calibration disk based on the one or more CT images.

Abstract: A method for generating an immune score, the method comprising the steps of: (i) determining a qualitative and/or quantitative assessment of tumor infiltrating lymphocytes in a sample; (ii) determining a qualitative and/or quantitative assessment of T-cell receptor signaling in the sample; (iii) determining a qualitative and/or quantitative assessment of mutation burden in the sample; (iv) generating, using a predictive algorithm, an immune score based on the determined qualitative and/or quantitative assessment of tumor infiltrating lymphocytes, the determined qualitative and/or quantitative assessment of T-cell receptor signaling, and the determined qualitative and/or quantitative assessment of mutation burden.

Abstract: A method may include positioning at least one calibration disk in a computed tomography (CT) scanner and positioning a pellet in the CT scanner. The at least one calibration disk and the pellet may both be made of a same powder exhibiting a known density. The method may further include scanning the at least one calibration disk and the pellet using the CT scanner to obtain one or more CT images of the pellet and the at least one calibration disk, and comparing a density of the pellet with the known density of the at least one calibration disk based on the one or more CT images.

Abstract: A liner (18) for a shaped-charge (10) that is compressively formed from a mixture of powdered metal, powdered metal binder, and a selected quantity of nanoparticle material, is used to achieve improved penetration depths during perforation of a wellbore. Exemplary nanoparticles include lead, tin, copper, molybdenum, etc. Such nanoparticles increase the density, sound speed, or acoustic impedance of the liner. In another embodiment, the added nanoparticles comprise reactive materials which, after penetration into the formation, cause secondary reactions in the perforations.