Abstract: Medical devices, such as implants, and corresponding methods of manufacturing using an additive manufacturing technique, wherein the finished medical devices include a build plate retained therein, are disclosed. In some embodiments, the medical device includes a build plate having a plurality of peaks and a plurality of indentations, the plurality of peaks and the plurality of indentations together defining a surface roughness of an exterior surface of the build plate. The medical device may further include a first layer formed atop the exterior surface of the build plate, the first layer comprising a plurality of powder structures disposed over the plurality of peaks and the plurality of indentations. In some embodiments, an average peak distance between adjacent peaks of the plurality of peaks is less than an average width dimension of at least a portion of the plurality of powder structures.

Abstract: There is provided a tibial component (100) comprising a tibial tray (102) having a superior side and an inferior side, and a support member (104) connected to the inferior side of the tibial tray, the support member having a stem portion (120), the stem portion including one or more fins (130) and a first arm (134) angled relative to a second arm (136). In one form, the fins have a curvature that extends away from the stem portion. In another form, the first arm defines an opening sized to receive an anchor wherein the anchor is configured to penetrate a portion of bone and the opening in the first arm. Optionally, the stem portion includes a first portion (1022) having a first cross sectional area and a second portion (1024) having a second cross sectional area wherein the first cross sectional area is larger than the second cross sectional area. The fins and arms can include rail protrusions (1186).

Abstract: In one preferred aspect, a surgical instrument for insertion into human tissue is provided with a release mechanism that permits one or more components of the surgical instrument to be removably coupled to a handle.

Abstract: In one preferred aspect, a method is provided for forming an opening in bone for the sequential dilation of tissue.

Abstract: In one preferred aspect, a method is provided for inserting an instrument set having a tapered configuration into a patient. In another preferred aspect, a method is provided for inserting a cannula having an external threaded portion into bone. In yet another preferred aspect, a method is provided for forming and enlarging an opening in bone.

Abstract: An instrument set is provided that has a tapered configuration that facilitates the insertion of the instrument set into a patient.

Abstract: The present invention relates to a method for enhancing ingrowth of host bone comprising: modifying a bone graft structure to provide an ionic gradient to produce a modified bone graft structure; and implanting the modified bone graft structure. The present invention also relates to a method of enhancing the binding of growth factors and cell cultures to a bone graft structure comprising: applying ex vivo an effective quantity of an ionic force change agent to the surface of a bone graft structure to produce a binding-sensitized bone graft structure; implanting said binding-sensitized bone graft structure into a host bone; and administering to said binding-sensitized bone graft structure a molecule, a cell culture or a combination thereof.

Abstract: Techniques and systems for distracting a spinal disc space and supporting adjacent vertebrae are provided. Trial instruments are insertable into the disc space to determine a desired disc space height and to select a corresponding implant. Implants can be also be self-distracting and the implant providing the desired disc space height can be implanted in the spinal disc space.

Abstract: An improved osteoimplant device and method for producing it. Bone particles are mixed with a polymer and a solvent. The mixture is formed into the shape of an osteoimplant and substantially all of the solvent is removed. The osteoimplant may be osteoinductive, osteoconductive, and load-bearing.