Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: A device includes a collimated light source operable to generate a collimated light source beam, which includes a beam direction. The device includes a first channel in a first plane and a second channel in a second plane different from the first plane. The second channel communicates with the first channel and includes a flow direction. The second channel is oriented to receive the collimated light source beam. The device includes a third channel in a third plane different from the second plane and communicates with the second channel. The collimated light source beam is oriented to enter a cross-section of the first channel, then to pass through the second channel, and then to enter a cross-section of the third channel such that the beam direction is opposite to the flow direction in the second channel. The device includes a focused particle stream nozzle operably connected to the first channel.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: A device includes a collimated light source operable to generate a collimated light source beam, which includes a beam direction. The device includes a first channel in a first plane and a second channel in a second plane different from the first plane. The second channel communicates with the first channel and includes a flow direction. The second channel is oriented to receive the collimated light source beam. The device includes a third channel in a third plane different from the second plane and communicates with the second channel. The collimated light source beam is oriented to enter a cross-section of the first channel, then to pass through the second channel, and then to enter a cross-section of the third channel such that the beam direction is opposite to the flow direction in the second channel. The device includes a focused particle stream nozzle operably connected to the first channel.

Abstract: A method and system for generating vapors of liquid solutions where a pneumatically modulated liquid delivery system maintains a defined flow rate for a liquid solution. The pneumatically modulated liquid delivery system includes a flow meter configured to measure a flow rate for the liquid solution flowing from a pressure vessel; a microcontroller configured to determine a pressure necessary to achieve the defined flow rate; and an electronic pressure control unit configured to adjust the pressure inside the pressure vessel. The system includes a nebulizer coupled to the pneumatically modulated liquid delivery system configured to receive the liquid solution from the pneumatically modulated liquid delivery system at the defined flow rate and configured to generate an aerosol of the liquid solution. A heat tube can vaporize the aerosol generated by the nebulizer.

Abstract: A device and method for particle separation. The device includes at least one collimated light source operable to generate at least one collimated light source beam. The device further includes a first channel in a first plane and a focused particle stream nozzle operably connected to the first channel. The device further includes a second channel in a second plane orthogonal to the first plane. The second channel communicates with the first channel. The second channel comprises a second channel cross-section. The second channel is oriented to receive the collimated light source beam. The device further includes a third channel in a third plane orthogonal to the second plane. The third channel communicates with the second channel. The collimated light source beam is oriented to enter a cross-section of the first channel, then to pass through the second channel, and then to enter a cross-section of the third channel.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: A device and method for particle separation. The device includes at least one collimated light source operable to generate at least one collimated light source beam. The device further includes a first channel in a first plane and a focused particle stream nozzle operably connected to the first channel. The device further includes a second channel in a second plane orthogonal to the first plane. The second channel communicates with the first channel. The second channel comprises a second channel cross-section. The second channel is oriented to receive the collimated light source beam. The device further includes a third channel in a third plane orthogonal to the second plane. The third channel communicates with the second channel. The collimated light source beam is oriented to enter a cross-section of the first channel, then to pass through the second channel, and then to enter a cross-section of the third channel.

Abstract: A method of particle separation, wherein a collimated light source operable to generate a collimated light source beam is provided. The collimated light source beam includes a beam cross-section. A body is provided, wherein the body defines a wall and a first channel in a first plane. The first channel includes a first channel cross-section, the first channel being oriented to receive the collimated light source beam such that the beam cross-section completely overlaps the channel cross-section. The collimated light source beam is transmitted through the channel. A fluid sample is transmitted through the channel, fluid sample including a plurality of particles of a same type. All of the particles of the plurality of particles are separated axially along the collimated light source beam. All of the particles of the plurality of particles are retained against the wall in the collimated light source beam.

Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.

Abstract: A method and system for generating vapors of liquid solutions where a pneumatically modulated liquid delivery system maintains a defined flow rate for a liquid solution. The pneumatically modulated liquid delivery system includes a flow meter configured to measure a flow rate for the liquid solution flowing from a pressure vessel; a microcontroller configured to determine a pressure necessary to achieve the defined flow rate; and an electronic pressure control unit configured to adjust the pressure inside the pressure vessel. The system includes a nebulizer coupled to the pneumatically modulated liquid delivery system configured to receive the liquid solution from the pneumatically modulated liquid delivery system at the defined flow rate and configured to generate an aerosol of the liquid solution. A heat tube can vaporize the aerosol generated by the nebulizer.

Abstract: A method of particle separation, wherein a collimated light source operable to generate a collimated light source beam is provided. The collimated light source beam includes a beam cross-section. A body is provided, wherein the body defines a wall and a first channel in a first plane. The first channel includes a first channel cross-section, the first channel being oriented to receive the collimated light source beam such that the beam cross-section completely overlaps the channel cross-section. The collimated light source beam is transmitted through the channel. A fluid sample is transmitted through the channel, fluid sample including a plurality of particles of a same type. All of the particles of the plurality of particles are separated axially along the collimated light source beam. All of the particles of the plurality of particles are retained against the wall in the collimated light source beam.

Abstract: A device and method of using same, wherein the device includes a collimated light source operable to generate a collimated light source beam, the collimated light source beam comprising a beam cross-section. The device further includes at least one body defining a first channel in a first plane, the first channel comprising a first channel cross-section, the first channel being oriented to receive the collimated light source beam such that the beam cross-section completely overlaps the first channel cross-section. Optionally, the body defines a second channel in a second plane orthogonal to the first plane, wherein the body defines a third channel in a third plane orthogonal to the first plane.

Abstract: A multi-criteria event detection system, comprising a plurality of sensors, wherein each sensor is capable of detecting a signature characteristic of a presence of an event and providing an output indicating the same. A processor for receiving each output of the plurality of sensors is also employed. The processor includes a probabilistic neural network for processing the sensor outputs. The probabilistic neural network comprises a nonlinear, nor-parametric pattern recognition algorithm that operates by defining a probability density function for a plurality of data sets that are each based on a training set data and an optimized kernel width parameter. The plurality of data sets includes a baseline, non-event, first data set; a second, event data set; and a third, nuisance data set.