Patents by Inventor Sean LANDRETTE

Sean LANDRETTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating cancer using apilimod
    Patent number: 10350213
    Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: July 16, 2019
    Assignee: AI Therapeutics, Inc.
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Sophia Gayle, Neil Beeharry, Paul Beckett, Sean Landrette, Chris Conrad, Tian Xu
  • APILIMOD FOR USE IN THE TREATMENT OF COLORECTAL CANCER
    Publication number: 20190209576
    Abstract: The present invention relates to methods for treating colorectal cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: November 6, 2015
    Publication date: July 11, 2019
    Inventors: Neil BEEHARRY, Sophia GAYLE, Sean LANDRETTE, Paul BECKETT, Chris CONRAD, Tian XU, Marylens HERNANDEZ, Jonathan M. ROTHBERG, Henri LICHENSTEIN
  • APILIMOD FOR USE IN THE TREATMENT OF RENAL CANCER
    Publication number: 20190201385
    Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: December 19, 2018
    Publication date: July 4, 2019
    Inventors: Neil Beeharry, Sophia Gayle, Sean Landrette, Paul Beckett, Chris Conrad, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • Apilimod Compositions and Methods for Using Same
    Publication number: 20190183902
    Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: November 16, 2018
    Publication date: June 20, 2019
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Sophia Gayle, Neil Beeharry, Paul Beckett, Sean Landrette, Chris Conrad, Matt Dyer, Tian Xu
  • THERAPEUTIC METHODS RELATING TO HSP90 INHIBITORS
    Publication number: 20190091229
    Abstract: The disclosure provides methods for treating cancer, including but not limited to, hematopoietic and lung cancers, using the HSP90 inhibitor, MPC-0767, as monotherapy and in combination therapy with additional active agents, including but not limited to, inhibitors of Bcl-2, EZH2 inhibitors, Ras/Raf/MEK/ERK pathway inhibitors, checkpoint inhibitors, DNMT inhibitors, ATO and chemotherapeutic agents. The disclosure also provides related compositions and methods of use.
    Type: Application
    Filed: September 27, 2018
    Publication date: March 28, 2019
    Inventors: Henri Lichenstein, Neil Beeharry, Sean Landrette, Sophia Gayle, Jeff Grotzke, Marylens Hernandez, Peter R. Young, Jonathan M. Rothberg
  • Apilimod for use in the treatment of renal cancer
    Patent number: 10206910
    Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: February 19, 2019
    Assignee: LAM Therapeutics, Inc.
    Inventors: Neil Beeharry, Sophia Gayle, Sean Landrette, Paul Beckett, Chris Conrad, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • Biomarkers for Treating Cancer with Apilimod
    Publication number: 20190015421
    Abstract: The present disclosure relates to compositions and methods for treating cancer in a subject having cancer cells over-expressing a microphthalmia (MiT) transcription factor with apilimod and related compositions and methods.
    Type: Application
    Filed: January 20, 2017
    Publication date: January 17, 2019
    Inventors: Sophia Gayle, Neil Beeharry, Sean Landrette, Chris Conrad, Paul Beckett, Marylens Hernandez, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • Apilimod compositions and methods for using same
    Patent number: 10179135
    Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: January 15, 2019
    Assignee: LAM Therapeutics, Inc.
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Sophia Gayle, Neil Beeharry, Paul Beckett, Sean Landrette, Chris Conrad, Matt Dyer, Tian Xu
  • Compositions and Methods Relating to the Radioprotective Effects of Apilimod
    Publication number: 20180280403
    Abstract: The present disclosure relates to methods for preventing or treating a radiation-induced disease, disorder, or condition by administering apilimod to a subject in need thereof, and related compositions.
    Type: Application
    Filed: March 28, 2018
    Publication date: October 4, 2018
    Inventors: Sean Landrette, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • Methods for treating cancer using HSP90 inhibitors
    Publication number: 20180221376
    Abstract: The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of low dose' HSP90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 9, 2018
    Inventors: Neil Beeharry, Marylens Hernandez, Sean Landrette, Tian Xu, Jonathan M. Rothberg, Henri Lichenstein
  • ACTIVE METABOLITES OF APILIMOD AND USES THEREOF
    Publication number: 20180078561
    Abstract: The present invention relates to compositions comprising one or more active metabolites of apilimod and methods for their use in treating cancer.
    Type: Application
    Filed: January 21, 2016
    Publication date: March 22, 2018
    Inventors: Paul Beckett, Neil Beeharry, Sean Landrette, Chris Conrad, Jonathan M. Rothberg, Henri Lichenstein
  • ANTI-VIRAL COMPOSITIONS CONTAINING PIKFYVE INHIBITORS AND USE THEREOF
    Publication number: 20180028540
    Abstract: The present invention relates to compositions containing a PIKfyve inhibitor, preferably apilimod, APY0201 or YM-201636, most preferably apilimod, for use in treating or preventing viral infections, preferably Ebola or Marburg virus infections. It also relates to a pharmaceutical pack or kit comprising apillimod and at least one additional anti-viral agent.
    Type: Application
    Filed: January 21, 2016
    Publication date: February 1, 2018
    Inventors: Henri LICHENSTEIN, Jonathan M. ROTHBERG, Neil BEEHARRY, Paul BECKETT, Sean LANDRETTE, Chris CONRAD
  • APILIMOD FOR USE IN THE TREATMENT OF MELANOMA
    Publication number: 20170333439
    Abstract: The present invention relates to methods for treating melanoma with apilimod and related compositions and methods.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 23, 2017
    Inventors: Neil BEEHARRY, Sophia GAYLE, Sean LANDRETTE, Paul BECKETT, Chris CONRAD, Tian XU, Jonathan M. ROTHBERG, Henri LICHENSTEIN
  • APILIMOD FOR USE IN THE TREATMENT OF RENAL CANCER
    Publication number: 20170333408
    Abstract: The present disclosure relates to methods for treating renal cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 23, 2017
    Inventors: Neil BEEHARRY, Sophia GAYLE, Sean LANDRETTE, Paul BECKETT, Chris CONRAD, Tian XU, Jonathan M. ROTHBERG, Henri LICHENSTEIN
  • Methods for Treating Cancer Using Apilimod
    Publication number: 20170020884
    Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: July 19, 2016
    Publication date: January 26, 2017
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Sophia Gayle, Neil Beeharry, Paul Beckett, Sean Landrette, Chris Conrad, Tian Xu
  • Apilimod Compositions and Methods for Using Same
    Publication number: 20170007613
    Abstract: The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
    Type: Application
    Filed: January 23, 2015
    Publication date: January 12, 2017
    Inventors: Henri Lichenstein, Jonathan M. Rothberg, Sophia Gayle, Neil Beeharry, Paul Beckett, Sean Landrette, Chris Conrad, Matt Dyer, Tian Xu
  • COMPOSITIONS AND METHODS OF USING TRANSPOSONS
    Publication number: 20160273046
    Abstract: The present invention provides compositions and methods of using transposons. In one aspect, methods are disclosed that are useful for identifying negatively selected genes in an insertional mutagenesis screen. In another aspect, compositions for reducing proliferation of a tumor cell expressing an oncogenic RAS include an activator of a WNT pathway. Pharmaceutical compositions for reducing proliferation of tumor cells in a subject in need thereof by administering an effective amount of an activator of a WNT pathway to the tumor cells of the subject are also disclosed.
    Type: Application
    Filed: November 17, 2014
    Publication date: September 22, 2016
    Inventors: Tian XU, Feng QIAN, Sean LANDRETTE