Patents by Inventor Sean McClain

Sean McClain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11878844
    Abstract: A lid that is designed to cover the lip of a disposable coffee cup. The lid defines a circular central wall on its top side that is designed to receive a lip of a disposable miniature coffee cup. The lid defines a perforated spout on its top side that opens outward toward the circumference of the lid. The lid is designed to serve as mount, after a first miniature coffee cup is inserted into the circular central wall, that will securely hold a stack of miniature coffee cups.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: January 23, 2024
    Inventor: Sean McClain
  • Publication number: 20230340501
    Abstract: The present invention provides methods of producing thrombin using coordinated coexpression systems, and particularly inducible coexpression systems, capable of controlled induction of expression of each gene product required for the production of thrombin.
    Type: Application
    Filed: May 1, 2023
    Publication date: October 26, 2023
    Inventors: Sean McClain, Mark Valasek, Andras Gruber
  • Publication number: 20220364104
    Abstract: The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Application
    Filed: May 19, 2022
    Publication date: November 17, 2022
    Inventors: Sean McClain, Mark Valasek, Philip Barish, Jeremy Minshull
  • Patent number: 11447781
    Abstract: The present invention provides host cells for use in an inducible coexpression system that is capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: September 20, 2022
    Assignee: ABSCI LLC
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 11371048
    Abstract: The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: September 11, 2016
    Date of Patent: June 28, 2022
    Assignee: ABSCI LLC
    Inventors: Sean McClain, Mark Valasek, Philip Barish, Jeremy Minshull
  • Publication number: 20220090093
    Abstract: The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 11214807
    Abstract: The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: January 4, 2022
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 10901190
    Abstract: A digital camera optically couples a monocentric lens to image sensor arrays, without optical fibers, yet shields the image sensor arrays from stray light. In some digital cameras, baffles are disposed between an outer surface of a monocentric lens and each image sensor array to shield the image sensor arrays from stray light. In other such digital cameras, an opaque mask defines a set of apertures, one aperture per image sensor array, to limit the amount of stray light. Some digital cameras include both masks and baffles.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: January 26, 2021
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Erik L. Waldron, Gregory P. Blasche, Paul Bohn, Robin Mark Adrian Dawson, Walter Foley, Samuel Harrison, Matthew T. Jamula, Juha-Pekka J. Laine, Benjamin F. Lane, Sean McClain, Francis J. Rogomentich, Stephen P. Smith, John James Boyle
  • Publication number: 20200270338
    Abstract: A cell for producing insulin includes an E. coli host cell and a polynucleotide designed for production of insulin disposed within the E. coli host cell. The polynucleotide includes a first inducible promoter and a first coding sequence to be transcribed from the first inducible promoter, the first coding sequence encoding an insulin polypeptide. The polynucleotide also includes a second inducible promoter and a second coding sequence to be transcribed from the second inducible promoter, the second coding sequence encoding one or more of cDsbA, cDsbC, a protein disulfide isomerase, Ervlp, and a chaperone. The first inducible promoter and the second inducible promoter are not responsive to the same inducer. A method of producing insulin includes growing a sample of the cells in a fermentation volume between 0.1 L and 1,000,000 L, adding an inducer of the first inducible promoter to induce expression of the insulin polypeptide, and purifying the insulin polypeptide.
    Type: Application
    Filed: May 11, 2020
    Publication date: August 27, 2020
    Applicant: AbSci LLC
    Inventors: Sean McClain, Philip Barish
  • Publication number: 20200172915
    Abstract: The present invention provides host cells for use in an inducible coexpression system that is capable of controlled induction of expression of each gene product.
    Type: Application
    Filed: February 13, 2020
    Publication date: June 4, 2020
    Applicant: AbSci LLC
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 10604761
    Abstract: The present invention provides host cells for use in an inducible coexpression system that is capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: March 31, 2020
    Assignee: AbSci LLC
    Inventors: Sean McClain, Mark Valasek
  • Publication number: 20200063116
    Abstract: The present invention provides methods of producing thrombin using coordinated coexpression systems, and particularly inducible coexpression systems, capable of controlled induction of expression of each gene product required for the production of thrombin.
    Type: Application
    Filed: November 5, 2019
    Publication date: February 27, 2020
    Inventors: Sean McClain, Mark Valasek, Andras Gruber
  • Publication number: 20200032276
    Abstract: The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Application
    Filed: October 7, 2019
    Publication date: January 30, 2020
    Applicant: AbSci, LLC
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 10508270
    Abstract: The present invention provides methods of producing thrombin using coordinated coexpression systems, and particularly inducible coexpression systems, capable of controlled induction of expression of each gene product required for the production of thrombin, and the thrombin produced by this method.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: December 17, 2019
    Assignees: AbSci LLC, Aronora Inc.
    Inventors: Sean McClain, Mark Valasek, Andras Gruber
  • Patent number: 10465197
    Abstract: The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: November 5, 2019
    Assignee: AbiSci, LLC
    Inventors: Sean McClain, Mark Valasek
  • Publication number: 20180282405
    Abstract: The present invention provides host cells having an oxidizing cytoplasm, which are capable of growing to high cell densities and producing recombinant proteins in soluble form. Also provided are methods for growing such host cells to high densities, methods for optionally modulating the growth rates of the host cells, and methods for inducing the host cells to produce the desired gene product in soluble form. Further aspects of the invention relate to host cell preparation and storage methods, which utilize the advantages of producing gene products in host cell cytoplasm to provide methods for long-term storage and/or transport of expressed gene products that are retained in a stable and soluble form within the host cells.
    Type: Application
    Filed: June 14, 2018
    Publication date: October 4, 2018
    Applicant: AbSci, LLC
    Inventors: Sean McClain, Philip Barish
  • Patent number: 9766041
    Abstract: A device and method for selectively illuminating and designating multiple targets in the air or on the ground simultaneously. The device comprises a light source, a switching array and a ball lens. Light from the light source is routed through the switching array, which can addressably output multiple light beams simultaneously. The light beams from the switching array illuminate the backside of a low F-number ball lens. The ball lens creates highly collimated output beams independently (and simultaneously) from any of the output source points of the switching array. These output beams can be used to simultaneously designate multiple targets. When the target illuminating device includes an optional detector array, light scattered from targets can be refracted by the balls lens to impinge on the detector array. Signals from the detector array representing the received light beams can be used for target imaging.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: September 19, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Juha-Pekka Laine, Gregory Blasche, Robin Dawson, Sean McClain, Stephen P. Smith, Robert Larsen, Charles Arant, William Ostrowski
  • Publication number: 20170159061
    Abstract: The present invention provides host cells for use in an inducible coexpression system that is capable of controlled induction of expression of each gene product.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Applicant: AbSci, LLC
    Inventors: Sean McClain, Mark Valasek
  • Patent number: 9653003
    Abstract: Methods and apparatus ascertain a geographic position based on topographic contours of ocean surfaces. Observed ocean topographic contours are matched to predicted ocean topography and/or ocean topographic information stored in a database. Such systems and methods do not necessarily require INS, GPS, RF beacons, optical beacons or celestial sightings. These systems and methods may be used as references to correct INS. These systems and methods may be used to ascertain a geographic location of an aircraft, spacecraft, watercraft, landcraft (vehicle), person or the like. Similarly, these systems and methods may be used as part of a guidance system for guiding a craft to a destination. These systems and methods may be used in tandem with, or as backups for, other types of navigation or guidance systems or as one input to a navigation filter.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: May 16, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Juha-Pekka J. Laine, Gregory P. Blasche, Paul Bohn, Robin Mark Adrian Dawson, Walter Foley, Benjamin F. Lane, Sean McClain, Erik L. Waldron, Stephen P. Smith
  • Patent number: 9617335
    Abstract: The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: April 11, 2017
    Assignee: AbSci LLC
    Inventors: Sean McClain, Mark Valasek