Patents by Inventor Sebastian J Osterfeld
Sebastian J Osterfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220365029Abstract: Provided are methods of evaluating a sample for presence of an analyte using a magnetic sensor and a dissociation reagent. In some embodiments the sample is magnetically labelled and bound to the magnetic sensor, after which a dissociation reagent is introduced to dissociate the magnetic label from the magnetic sensor. The magnetic sensor can be used to detect the magnetically labeled analyte before and after introduction of the dissociation reagent, thereby allowing for evaluating of the presence of the analyte. Exemplary samples include aqueous solutions containing proteins, DNA, RNA, and other biologically relevant analytes. In some cases the methods provide for an increase in the speed at which the magnetic sensor can evaluate samples. Also provided are apparatuses and kits for performing the methods.Type: ApplicationFiled: May 9, 2022Publication date: November 17, 2022Inventors: Sebastian J. Osterfeld, Heng Yu
-
Patent number: 11175358Abstract: Aspects of the present disclosure include magnetic sensor devices having a mixed oxide passivation layer. Magnetic sensor devices according to certain embodiments include a magnetic sensor element and a passivation layer having two or more of zirconium oxide, aluminum oxide and tantalum oxide. Also provided are magnetic sensor devices having an encapsulating passivation layer. Magnetic sensor devices according to certain embodiments include a substrate, a magnetic sensor element and a passivation layer that encapsulates the magnetic sensor element. Methods for making a magnetic sensor with a passivation layer are described. Methods and systems for detecting one or more analytes in a sample are also described. Aspects further include kits having one or more of the subject magnetic sensor devices and a magnetic label.Type: GrantFiled: June 19, 2019Date of Patent: November 16, 2021Assignee: MagArray, Inc.Inventors: Shan Xiang Wang, Sebastian J. Osterfeld
-
Publication number: 20210041434Abstract: Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction, for example wherein the determination involves a complex sample, are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a complex sample including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.Type: ApplicationFiled: August 5, 2020Publication date: February 11, 2021Inventors: Heng Yu, Sebastian J. Osterfeld, Kalidip Choudhury
-
Patent number: 10809253Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.Type: GrantFiled: December 4, 2017Date of Patent: October 20, 2020Assignees: MagArray, Inc., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Shan Xiang Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
-
Patent number: 10802089Abstract: Provided are magnetic sensors, which include a magnetic sensor element having a sensor surface modification and an inter-element area adjacent to the magnetic sensor element and having an inter-element area surface modification, where the sensor surface modification and the inter-element area surface modification provide a binding surface in the inter-element area. Also provided are devices, systems and methods in which the subject magnetic sensors find use.Type: GrantFiled: May 10, 2016Date of Patent: October 13, 2020Assignee: MagArray, Inc.Inventors: Sebastian J. Osterfeld, Heng Yu
-
Publication number: 20200041585Abstract: Aspects of the present disclosure include magnetic sensor devices having a mixed oxide passivation layer. Magnetic sensor devices according to certain embodiments include a magnetic sensor element and a passivation layer having two or more of zirconium oxide, aluminum oxide and tantalum oxide. Also provided are magnetic sensor devices having an encapsulating passivation layer. Magnetic sensor devices according to certain embodiments include a substrate, a magnetic sensor element and a passivation layer that encapsulates the magnetic sensor element. Methods for making a magnetic sensor with a passivation layer are described. Methods and systems for detecting one or more analytes in a sample are also described. Aspects further include kits having one or more of the subject magnetic sensor devices and a magnetic label.Type: ApplicationFiled: June 19, 2019Publication date: February 6, 2020Inventors: Shan Xiang Wang, Sebastian J. Osterfeld
-
Patent number: 10267871Abstract: Provided are magnetic sensors, which include a magnetic tunnel junction (MTJ) magnetoresistive element, a first electrode contacting at least a portion of a surface of the MTJ magnetoresistive element and extending beyond an edge of the surface of the MTJ magnetoresistive element, and a second electrode contacting at least a portion of an opposing surface of the MTJ magnetoresistive element and extending beyond an edge of the opposing surface of the MTJ magnetoresistive element, where facing surfaces of the extending portions of the first and second electrodes are non-overlapping. Also provided are devices, systems and methods in which the subject magnetic sensors find use.Type: GrantFiled: March 13, 2014Date of Patent: April 23, 2019Assignee: MagArray, Inc.Inventors: Sebastian J. Osterfeld, Shan Xiang Wang
-
Publication number: 20180128822Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.Type: ApplicationFiled: December 4, 2017Publication date: May 10, 2018Inventors: Shan Xiang Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
-
Patent number: 9863939Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.Type: GrantFiled: September 19, 2008Date of Patent: January 9, 2018Assignees: MagArray, Inc., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Shan X. Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
-
Patent number: 9528995Abstract: Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.Type: GrantFiled: September 4, 2015Date of Patent: December 27, 2016Assignee: MagArray, Inc.Inventors: Sebastian J. Osterfeld, Shan Xiang Wang
-
Publication number: 20160334370Abstract: Provided are magnetic sensors, which include a magnetic sensor element having a sensor surface modification and an inter-element area adjacent to the magnetic sensor element and having an inter-element area surface modification, where the sensor surface modification and the inter-element area surface modification provide a binding surface in the inter-element area. Also provided are devices, systems and methods in which the subject magnetic sensors find use.Type: ApplicationFiled: May 10, 2016Publication date: November 17, 2016Inventors: Sebastian J. Osterfeld, Heng Yu
-
Publication number: 20150377893Abstract: Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.Type: ApplicationFiled: September 4, 2015Publication date: December 31, 2015Inventors: Sebastian J. Osterfeld, Shan Xiang Wang
-
Patent number: 9164100Abstract: Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.Type: GrantFiled: November 16, 2012Date of Patent: October 20, 2015Assignee: MagArray, Inc.Inventors: Sebastian J. Osterfeld, Shan X. Wang
-
Patent number: 9151763Abstract: Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.Type: GrantFiled: March 9, 2012Date of Patent: October 6, 2015Assignee: MagArray, Inc.Inventors: Sebastian J. Osterfeld, Shan X. Wang
-
Publication number: 20140266186Abstract: Provided are magnetic sensors, which include a magnetic tunnel junction (MTJ) magnetoresistive element, a first electrode contacting at least a portion of a surface of the MTJ magnetoresistive element and extending beyond an edge of the surface of the MTJ magnetoresistive element, and a second electrode contacting at least a portion of an opposing surface of the MTJ magnetoresistive element and extending beyond an edge of the opposing surface of the MTJ magnetoresistive element, where facing surfaces of the extending portions of the first and second electrodes are non-overlapping. Also provided are devices, systems and methods in which the subject magnetic sensors find use.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Inventors: Sebastian J. Osterfeld, Shan Xiang Wang
-
Patent number: 8405385Abstract: Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.Type: GrantFiled: March 10, 2010Date of Patent: March 26, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Drew A. Hall, Richard Gaster, Sebastian J. Osterfeld, Shan X. Wang
-
Publication number: 20120231960Abstract: Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.Type: ApplicationFiled: March 9, 2012Publication date: September 13, 2012Inventors: Sebastian J. Osterfeld, Shan X. Wang
-
Publication number: 20100231203Abstract: Double modulation of a magnetoresistive sensor entails modulating both an excitation (e.g., voltage or current) applied to the sensor and a tickling magnetic field applied to the sensor. The excitation and magnetic field are modulated at different frequencies fc and ff, respectively. As a result of the double modulation, the sensor output spectrum includes a carrier tone (CT) at frequency fc and side tones (STs) at frequencies fc±ff. A baseline relation between CT amplitude and ST amplitude is determined (e.g., by measuring CT and ST amplitude while drift occurs in the absence of a sample). During sensor operation, raw ST measurements are corrected using corresponding raw CT measurements to provide corrected ST measurements as the sensor output.Type: ApplicationFiled: March 10, 2010Publication date: September 16, 2010Inventors: Drew A. Hall, Richard Gaster, Sebastian J. Osterfeld, Shan X. Wang
-
Publication number: 20090104707Abstract: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from the magnetic sensor to determine whether the analyte is present in the sample. Also provided are devices, systems and kits that find use in practicing the methods of the invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including detection of biomarkers, such as disease markers.Type: ApplicationFiled: September 19, 2008Publication date: April 23, 2009Inventors: Shan X. Wang, Sebastian J. Osterfeld, Heng Yu, Nader Pourmand, Robert L. White
-
Patent number: 7419639Abstract: The present invention provides microfluidic devices constructed from four layers. The layers include a rigid substrate layer, a patterned rigid layer having thickness t, a patterned elastomeric layer having thickness greater than t, and a rigid support layer. Microfluidic structures in the devices are defined by the alignment of openings in the patterned rigid layer and the patterned elastomeric layer. The rigid support layer, rigid substrate layer, and patterned rigid layer may be made of any rigid material, including but not limited to plastic or silicon-containing materials, such as glass, quartz, or SiO2-coated materials. Similarly, the patterned elastomeric layer may be made of any elastomeric material, including but not limited to polydimethylsiloxanes, polymethylmethacrylates, perfluoropolyethers, or combinations thereof. Microfluidic devices according to the present invention may include sensors or sensor arrays.Type: GrantFiled: March 22, 2006Date of Patent: September 2, 2008Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sebastian J Osterfeld, Shan X. Wang