Abstract: The invention relates to a method for screening of at least one chemical substance by treatment of plant material, comprising the following process steps: a) Applying the plant material into a cavity; b) Treatment of the plant material with the chemical substance; c) Creating at least one dataset showing at least one phenotypical characteristic of the plant material after treatment with the chemical substance; and d) Assigning the chemical substance based on the dataset to at least one site of action (SoA) and/or at least one mode of action (MoA) of a multitude of stored SoA and/or MoA by using a SoA- and/or MoA-compendium containing data regarding dependencies between phenotypical characteristics of at least one plant material treated by at least one reference substance of a known SoA and/or MoA.