Abstract: The disclosure relates to a composition of nanoparticles as carrier for HPV-derived immunogenic fragments and the use of the composition for medical purposes, in particular for immunoprophylaxis or immunotherapy. The invention also relates to a vaccine containing the composition and/or nanoparticles.

Abstract: The present disclosure generally relates to a cost-based optimizer for efficiently processing data through the use of multiple different data processing platforms. The cost-based optimizer may receive an input plan for processing data that includes a number of base operators. The cost-based optimizer may then determine execution operators for each base operator, where each execution operator corresponds to a different data processing platform. From the execution operators, the cost-based optimizer may determine possible subplans for executing the input plan on one or more data processing platforms. The cost-based optimizer may determine the cost of executing each possible subplan and choose the subplan with the lowest cost.

Abstract: A computer implemented method for integrating data into a target database may include: providing a plurality of source databases which each may include a relational schema and data for integration into the target database; generating at least one complexity model based on the relational schema and data of each source database, each complexity model indicating at least one inconsistency between two or more of the data sources which may be require to be resolved to integrate the data from the data sources into the target database; and generating an effort model that may include an effort value for each inconsistency indicated by each complexity model, each effort value indicating at least one of a time period and a financial cost to resolve the inconsistency to integrate data from the data sources into the target database.

Abstract: The present disclosure generally relates to a cost-based optimizer for efficiently processing data through the use of multiple different data processing platforms. The cost-based optimizer may receive an input plan for processing data that includes a number of base operators. The cost-based optimizer may then determine execution operators for each base operator, where each execution operator corresponds to a different data processing platform. From the execution operators, the cost-based optimizer may determine possible subplans for executing the input plan on one or more data processing platforms. The cost-based optimizer may determine the cost of executing each possible subplan and choose the subplan with the lowest cost.

Abstract: A computer implemented method for integrating data into a target database may include: providing a plurality of source databases which each may include a relational schema and data for integration into the target database; generating at least one complexity model based on the relational schema and data of each source database, each complexity model indicating at least one inconsistency between two or more of the data sources which may be require to be resolved to integrate the data from the data sources into the target database; and generating an effort model that may include an effort value for each inconsistency indicated by each complexity model, each effort value indicating at least one of a time period and a financial cost to resolve the inconsistency to integrate data from the data sources into the target database.

Abstract: A powered lower extremity orthotic, including a shank link coupled to an artificial foot, a knee mechanism connected to the shank link and a thigh link, is controlled by based on signals from various orthotic mounted sensors such that the artificial foot follows a predetermined trajectory defined by at least one Cartesian coordinate.

Abstract: A semi-actuated above knee prosthetic system, which is mostly passive in nature and includes a shank link coupled to an artificial foot, a knee mechanism connected to the shank link and a thigh link attached to an above-knee remaining lower limb of an amputee, is operable in either an actuated mode or an un-actuated mode controlled by a signal processor linked to various prosthetic mounted sensors which may include combinations of knee angle, stance, thigh angle and shank angle sensors. Power is delivered through an electric motor connected to a battery source and employed to drive a hydraulic pump which is part of an overall hydraulic power unit including the torque generator. A signal processor selects a swing state from at least forward, combination forward and descent, combination forward and ascent, reverse, combination reverse and descent, and combination reverse and ascent swing states.

Abstract: A semi-actuated above knee prosthetic system, which is mostly passive in nature and includes a shank link coupled to an artificial foot, a knee mechanism connected to the shank link and a thigh link attached to an above-knee remaining lower limb of an amputee, is operable in either an actuated mode or an un-actuated mode controlled by a signal processor linked to various prosthetic mounted sensors. In the actuated mode, power is delivered to a torque generator connected to the knee mechanism to cause a forced movement between the thigh and shank links. In the un-actuated mode, a control circuit operates in a non-powered manner to allow operation of the knee mechanism with modulated resistance. Power is delivered through an electric motor connected to a battery source and employed to drive a hydraulic pump which is part of an overall hydraulic power unit including the torque generator.