Abstract: The present invention provides a compound of Formula (I) Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

Abstract: The invention relates to a bottle lock for a bottle, comprising a housing part designed to enclose an upper portion of the bottle neck of the bottle to be secured, including the bottle cap of the bottle to be secured, a plurality of claws arranged in the housing part, which are designed and intended to engage non-releasably with the upper portion of the bottle neck when the bottle lock is in a secured state and to allow the bottle lock to be released and removed away from the upper portion of the bottle neck in the released state of the bottle lock, and to a locking mechanism intended to assume an unlocked state in which the bottle lock can be transferred from the secured state to the released state, and a locked state in which the bottle lock cannot be transferred from the secured state to the released state.

Abstract: A computer-implemented method and a corresponding apparatus are provided for the provision of a two-dimensional visualization image having a plurality of visualization pixels for the visualization of a three-dimensional object represented by volume data for a user. Context information for the visualization is obtained by the evaluation of natural language and is taken into account in the visualization. The natural language can be in the form of electronic documents, which are assigned or can be assigned to the visualization process. In addition, the natural language can be in the form of a speech input of a user, during or after the visualization.

Abstract: The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing a natural, pen-and-paper user experience that harnesses cutting edge artificial intelligence and machine learning to enhance user interactions with data in a suite of software applications. The pen-and-paper user experience may mimic the time-honored human tradition of writing with pen and paper, allowing users to work in an intuitive, productive, familiar fashion. The user experience may automatically retrieve objects, e.g., data, charts, tables, graphs, etc. from backend systems and display the objects in the user experience. The user experience may allow users to provide additional natural language directly on or around the objects and update the displayed results accordingly.

Abstract: An analog circuit arrangement (1) to variably set a voltage Uout, within defined voltage limits, has a non-inverting adder (10) with a positive input (11). A voltage divider (20), with at least a first stage (21) and a second stage (22), is connected to the positive input (11) of the adder (10). At least one stage has a parallel circuit of n resistors (R1, R2, . . . , Rn) that are each connected in series in a conduction path (L1, L2, . . . , Ln) to an overcurrent protection device (F1, F2, . . . , Fn). At least one device (30) actively changes one or more of the overcurrent protection devices (F1, F2, . . . , Fn) into a state that interrupts the respective affected conduction path (L1, L2, . . . , Ln).

Abstract: The invention relates to an anti-theft device configured to be attached to merchandise to be protected the anti-theft device including a housing, which comprises a winding apparatus rotatably arranged therein, at least one securing-loop arrangement designed and intended to loop around the merchandise to be protected such that the anti-theft device can be securely connected to the merchandise to be protected, and a locking mechanism.

Abstract: Please substitute the new Abstract submitted herewith for the original Abstract: A system for increasing a degree of automation of a driver assistance system of a motor vehicle by using at least a second sensor and/or at least a second computing unit of a traffic participant in the surroundings of the motor vehicle is provided.

Abstract: The description relates to a joining head for fastening a fastening element by a die to the surface of a component with a gripper that can be linearly displaced in a first displacement direction RG and a magazine that can be linearly displaced in a second displacement direction RM. The magazine contains a plurality of fastening elements, with the first displacement direction RG running transversely to the second displacement direction RM.

Abstract: Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: The apparatus has a control unit, a connection unit and a vibration unit. The connection unit has a control-element-side region, an edge region and a flexible region, wherein the control-element-side region is flexibly mounted relative to the edge region by the flexible region. The control unit has a contact region, wherein the contact region is fixed relative to the control-element-side region. The control unit is configured to generate a contact signal based on contact with the contact region. The vibration unit is configured to induce a vibration of the contact region relative to the edge region during contact with the contact region.

Abstract: A crank device or crank drive is disclosed which has a crankshaft, into which a variable first force can be introduced by way of a transmission element over a variable first lever spacing. Here, the first variable force has a predefined profile and/or predefined change. A profile of the first variable lever spacing is designed in a manner which is dependent on the predefined profile of the first variable force in such a way that an effect of change in the first variable force on the crankshaft is at least partially compensated for. The compensation is provided over a rotational range of the crankshaft, which is preferably less than one revolution of the crankshaft.

Abstract: A method is described for providing a neural network for directly validating an environment map in a vehicle by means of sensor data. Valid or legitimate environment data is provided in a feature representation from map data and sensor data. Invalid or illegitimate environment data is provided in a feature representation from map data and sensor data. A neutral network is trained using the valid environment data and the invalid environment data.

Abstract: An apparatus for controlling at least one safety function of a motor vehicle is configured to determine a current driving situation of the motor vehicle, to determine a safety level required in the current driving situation of the motor vehicle, and to control the at least one safety function according to the required safety level.

Abstract: A battery system includes a plurality of battery cell packs arranged in layers selectively connected in series and parallel by a control system controlling a plurality of switches. Each of the battery cell packs includes a plurality of battery cells. A plurality of first switches and a plurality of second switches are controlled by a control system to connect the battery cell packs in response to a desired current output of the battery system and/or a desired voltage output of the battery system irrespective of individual battery cell or battery cell pack voltages or currents associated with state of charge or operational performance. The control system controls the switches to selectively connect the battery cell pack(s) to the output connections in parallel and/or series to provide redundancy and reduce output voltage/current fluctuation otherwise associated with state of charge or underperforming battery cells/packs.

Abstract: A process for operating a virtual sensor for determining the condition of a tool holder on a tool machine, such as a spindle, and the condition of a tool machine which has at least one tool holder and at least one tool, attached or attachable to the tool holder, which allows a workpiece to be processed by running a machine program, and which has at least one control unit comprising at least one sensor.

Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Abstract: A method for detection of a sub-synchronous oscillation in a power system includes measuring a three-phase measurement signal of an electric system value, analyzing the measurement signal to detect an oscillation component of the measurement signal having an oscillation frequency lower than a system frequency of the power system, deciding whether the detected oscillation component at the oscillation frequency qualifies as a sub-synchronous oscillation, and disconnecting a generator from the power system that might be affected by the sub-synchronous oscillation. To detect sub-synchronous oscillations with low computational effort and good accuracy, an amplitude of each phase of the oscillation component is calculated and compared against a threshold, a sub-synchronous oscillation is detected upon exceeding the threshold during a given time delay, and a fault signal is generated upon detecting a sub-synchronous oscillation. A device having a processing unit is also provided.

Abstract: The apparatus has a control unit, a connection unit and a vibration unit. The connection unit has a control-element-side region, an edge region and a flexible region, wherein the control-element-side region is flexibly mounted relative to the edge region by the flexible region. The control unit has a contact region, wherein the contact region is fixed relative to the control-element-side region. The control unit is configured to generate a contact signal based on contact with the contact region. The vibration unit is configured to induce a vibration of the contact region relative to the edge region during contact with the contact region.