Abstract: There is described a method for designing and manufacturing a protective glove, to be used for imparting slight knocks in performing a cycle of manual operations in an industrial production line and for absorbing the counter-knock received when using a tool or equipment gripped by the operator during said operating cycle. There are provided means for sensing the forces the various areas of the hand are subjected to during said operating cycle, and signals of said sensor means are processed so as to obtain a classification of the areas of the hand according to the value of the forces to which they are subjected. The glove is designed having areas that provide differentiated protections, having pads of different thickness calculated as a function of the aforementioned classification of the various areas of the hand.