Patents by Inventor Sei Hien Lim

Sei Hien Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic platform for investigating cell-based interactions
    Patent number: 10711234
    Abstract: A microfluidic platform for investigating cell-based interactions with a chip base is made of a suitable plastics material with the appropriate optical properties. The chip base has a plurality of ports in fluid communication with a microfluidic channel for containing a culture medium in which cells are held. A gas permeable laminate is bonded to a bottom surface of the chip base. Each port has an internal inlet, connecting the port with the microfluidic channel, and a trough for containing a small reservoir of culture medium fluid adjacent to the inlet. When in use, culture medium can be aspirated from the microfluidic channel via the trough rather than directly via the internal inlet.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 14, 2020
    Assignee: AIM BIOTECH PTE. LTD.
    Inventors: Andrea Pavesi, Sei Hien Lim, Swee Khuan Lim, Chee Mun Kuan
  • MICROFLUIDIC PLATFORM FOR INVESTIGATING CELL-BASED INTERACTIONS
    Publication number: 20180327700
    Abstract: A microfluidic platform for investigating cell-based interactions with a chip base is made of a suitable plastics material with the appropriate optical properties. The chip base has a plurality of ports in fluid communication with a microfluidic channel for containing a culture medium in which cells are held. A gas permeable laminate is bonded to a bottom surface of the chip base. Each port has an internal inlet, connecting the port with the microfluidic channel, and a trough for containing a small reservoir of culture medium fluid adjacent to the inlet. When in use, culture medium can be aspirated from the microfluidic channel via the trough rather than directly via the internal inlet.
    Type: Application
    Filed: November 9, 2015
    Publication date: November 15, 2018
    Inventors: Andrea Pavesi, Sei Hien Lim, Swee Khuan Lim, Chee Mun Kuan
  • Compositions and methods for neovascularization
    Patent number: 9446031
    Abstract: The invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1? (HIF-1?). In another aspect, the invention is directed to a method of inducing angiogenesis at a site in an individual in need thereof comprising administering locally to the site an effective amount of one or more agents that induce hypoxia induced factor 1? (HIF-1?) and one or more lysophospholipids. In addition, the invention is directed to methods of generating prevascularized tissue, methods of generating a vascular network in a device and compositions thereof.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: September 20, 2016
    Assignees: National University of Singapore, Massachusetts Institute of Technology
    Inventors: Michael Raghunath, Sei Hien Lim, Roger Dale Kamm