Abstract: Provided is a carboxylic acid co-modified organopolysiloxane that can stably and uniformly disperse various hydrophobic powders in an aqueous phase and has excellent functionality as a powder dispersant or the like. Compositions, such as topical agent compositions comprising the carboxylic acid co-modified organopolysiloxane, are also provided. The carboxylic acid co-modified organopolysiloxane is expressed by the following structural formula (1): where R1 is a C6 or lower hydrocarbon group or a hydrogen atom, R2 is a C6-30 monovalent hydrocarbon group, L1 is a specific organosilicon-containing organic group, Rc is a carboxyl group-containing organic group, R? is a group independently selected from the aforementioned R1, R2, L1 and Rc, but Rc and L1 are always included in the molecule.

Abstract: Provided is a co-modified organopolysiloxane that has excellent affinity and compatibility with a wide range of cosmetic product raw materials (particularly non-silicone oil agents such as fatty acid ester oils and the like), is less likely to cause thickening or inferior dispersion when used with powders, and can form favorable and stable slurries. The co-modified organopolysiloxane is expressed by structural formula (1) below, with an HLB value within a range of 0.5 to 2.0, and viscosity within a range of 200 to 1500 mPa·s. R2 is a monovalent hydrocarbon group having 6 to 30 carbon atoms, L1 is an organosilicon-containing organic group selected from silylalkyl groups having a carbosiloxy dendron structure and groups having a siloxane macromonomer structure, and Q is a hydrophilic group, which is a (poly)glycerin residual group or sugar alcohol residual group. The co-modified organopolysiloxane can be used as a powder dispersing agent or the like.

Abstract: There is provided a care-needing person assistance system that can efficiently collect stimulus information. The care-needing person assistance system includes a stimulus information storage means that stores stimulus information about a stimulus for at least one of five senses of a care-needing person, and a value exchange means that provides compensation for provision of stimulus information to a provider who provides new stimulus information to be additionally stored in the stimulus information storage means.

Abstract: Silicone particles having excellent dispersibility are provided via the method herein. A cosmetic material having excellent feeling of use, and a highly functional paint and an electronic material are also provided. The silicone particles include a siloxane as a component. A content of a hydrogen atom bonded to a silicon atom per unit mass is 300 ppm or less, or optionally is 20 ppm or less. In addition, the silicon atom in the siloxane as a component for the silicone particles is crosslinked with another silicon atom via an alkylene group having a carbon number of 4 to 20.

Abstract: The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the variable groups X, R1, R2, R3 m, n and p are as defined herein. The present disclosure also relates to methods for the preparation of at least one such entity, and intermediates useful in the preparation thereof, to pharmaceutical compositions containing at least one such entity, to the use of at least one such entity in the preparation of medicaments, and to the use of at least one such entity in the treatment of conditions such as, for example, allergic diseases, autoimmune diseases, viral diseases, and cancer.

Abstract: Provided is a cosmetic composition with excellent storage stability, feel during use and ultraviolet light blocking effects, in which an inorganic ultraviolet light blocking agent comprising a hydrophobic fine particulate metal oxide, e.g., hydrophobic fine particulate zinc oxide can be uniformly and stably dispersed in an aqueous phase, and in which a reduction in viscosity of a formulation is suppressed even when the structure of the hydrophobic fine particulate metal oxide is dispersed in the aqueous phase. The cosmetic composition comprises (A) a carboxylic acid modified silicone having a specific structure, (B) a water-soluble thickening agent, (C) a basic compound, and (D) a hydrophobic fine particulate metal oxide. The cosmetic composition is useful as a sunscreen cosmetic composition.

Abstract: Provided is an oil-in-water cleansing cosmetic composition. The oil-in-water cleansing cosmetic composition comprises: (A) carboxylic acid-modified silicone that is liquid at 50° C.; (B) 3 to 80 mass % of an oil agent relative to the total mass of the cosmetic composition; (C) water; and (D) a basic compound. An amount of an ionic surfactant other than the carboxylic acid-modified silicone (A) that is liquid at 50° C. is 10 mass % or less relative to the total mass of the cosmetic composition. In general, the oil-in-water cleansing cosmetic composition quickly blends with makeup grime, has a high makeup removing effect, and has excellent stability.

Abstract: An oil-in-water emulsion cosmetic composition is provided. The cosmetic composition comprises a carboxylic acid modified silicone (A) that is liquid state at 50° C., an oil agent (B), water (C), and an oil-soluble film-forming agent (D). The oil-soluble film-forming agent (D) is present in a range of 0.01 to 5 mass % of the total mass of the cosmetic composition. The cosmetic composition according can provide a cosmetic film with high stability and excellent water resistance.

Abstract: The present disclosure concerns at least one entity chosen from compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the variable groups X, R1, R2, R3 m, n and p are as defined herein. The present disclosure also relates to methods for the preparation of at least one such entity, and intermediates useful in the preparation thereof, to pharmaceutical compositions containing at least one such entity, to the use of at least one such entity in the preparation of medicaments, and to the use of at least one such entity in the treatment of conditions such as, for example, allergic diseases, autoimmune diseases, viral diseases, and cancer.

Abstract: A water repellent agent composition contains a compound represented by the following General Formula (1) and a silicone resin: wherein in Formula (1), R31 represents a monovalent hydrocarbon group having 4 to 30 carbon atoms, R32 represents a hydrogen, a monovalent hydrocarbon group having 1 to 30 carbon atoms, or an organic group represented by —R36—N(R37)—R38 (in the formula, R36 represents a divalent hydrocarbon group having 1 to 30 carbon atoms, and R37 and R38 each independently represent a hydrogen or a monovalent hydrocarbon group having 1 to 30 carbon atoms), R33 represents a divalent hydrocarbon group having 1 to 30 carbon atoms, R34 and R35 each independently represent a hydrogen or a monovalent hydrocarbon group having 1 to 30 carbon atoms, a represents an integer of 0 to 2, and when a is 2, the plurality of R32 and R33 each may be identical or different.

Abstract: A method of designing a film-forming agent for cosmetics, which can form a film having excellent water resistance and excellent sebum resistance while also having high washability, is provided. The method is also useful for designing a cosmetic containing the film-forming agent. The film-forming agent comprises a copolymer, which is formed by polymerizing a monomer composition. The monomer composition comprises: (A) an unsaturated monomer having at least one polysiloxane structure in the molecule; and (B) an unsaturated monomer having at least one acidic group or salt thereof in the molecule; wherein monomer (A) is present in an amount of at least 30 wt % relative to the weight of to the monomer composition.

Abstract: A copolymer having excellent water resistance and sebum resistance while also exhibiting high washability is provided. Also provided is a composition and cosmetic material containing the copolymer. The copolymer is generally polymerized from a monomer composition comprising: (A) a carbosiloxane dendrimer monomer having a radically polymerizable organic group; and (B) an unsaturated monomer having at least one acidic group or a salt thereof per molecule; wherein monomer (A) is present in the monomer composition in an amount greater than or equal to 30 wt. % relative to the weight of the monomer composition, and a weight ratio (A/B) of monomer (A) to monomer (B) is from 1.0 to 20.0.

Abstract: Provided is an oil-in-water emulsion cosmetic composition having a high UV protection or blocking effect (particularly, boost effect of SPF value) and excellent water resistance and the like of a film (e.g., cosmetic film) without impairing the tactile sensation or the feeling of use particular to the oil-in-water emulsion cosmetic composition. The oil-in-water emulsion cosmetic composition comprises: (A) a carboxylic acid-modified silicone in a liquid form at 50° C., (B) a vinyl-based polymer emulsion, (C) a basic compound, and (D) an inorganic UV protecting agent consisting of hydrophobic fine particulate metal oxide. The oil-in-water emulsion cosmetic composition is useful.

Abstract: An oil-in-water emulsion cosmetic composition is provided. The oil-in-water emulsion cosmetic composition comprises a carboxylic acid modified silicone (A) that has a specific chemical structure and is liquid at room temperature, an oil agent (B), and water (C). The oil-in-water emulsion cosmetic composition can provide a cosmetic film with high stability and excellent water resistance.

Abstract: An aqueous dispersion composition in which hydrophobic powders are stably and uniformly dispersed in an aqueous phase, which has excellent handling workability, and which can exhibit sufficient water repellency, water resistance, sebum resistance, and the like when compounded in a cosmetic composition or the like is provided. The aqueous dispersion composition contains at least (A) carboxylic acid-modified silicone in a liquid form at 50° C., (B) a hydrophobic powder, (C) a basic substance, and (D) water; and optionally (E) one or more alcohols selected from polyhydric alcohols and ethyl alcohols; wherein 80% by mass or more of a total composition is formed of the components (A) to (E), and component (B) is contained in a range of 10% to 70% by mass of the total composition, and component (A) is contained in a range of 5 to 30 parts by mass with respect to 100 parts by mass of component (B).

Abstract: A cosmetic composition is provided. The cosmetic composition comprises a carboxylic acid modified silicone (A) that has a specific chemical structure and is liquid at room temperature. The cosmetic composition also comprises an oil agent (B). The cosmetic composition generally provides a cosmetic film having excellent water resistance, and can be easily removed by normal soap and water.

Abstract: A treatment agent for a cosmetic powder is provided. The treatment agent contains a reactive organosiloxane represented by the following general formula (1) as a main ingredient: In general formula (1): each R1 is independently an alkyl group having 1 to 30 carbon atoms; each R2 is independently an alkyl group having 1 to 20 carbon atoms; R3 is a divalent alkylene group; n is an integer of 1 to 200; and p is an integer of 1 to 3. The treatment agent for a cosmetic powder of this disclosure is capable of imparting excellent lipophilicity. A cosmetic raw material having cosmetic effect and giving an excellent feeling of use, and a cosmetic are also provided.

Abstract: Silicone particles having excellent dispersibility are provided via the method herein. A cosmetic material having excellent feeling of use, and a highly functional paint and an electronic material are also provided. The silicone particles include a siloxane as a component. A content of a hydrogen atom bonded to a silicon atom per unit mass is 300 ppm or less, or optionally is 20 ppm or less. In addition, the silicon atom in the siloxane as a component for the silicone particles is crosslinked with another silicon atom via an alkylene group having a carbon number of 4 to 20.

Abstract: Silicone particles having excellent dispersibility are provided. A cosmetic material having excellent feeling of use, and a highly functional paint and an electronic material are also provided. The silicone particles include a siloxane as a component. A content of a hydrogen atom bonded to a silicon atom per unit mass is 300 ppm or less. In addition, the silicon atom in the siloxane as a component for the silicone particles is crosslinked with another silicon atom via an alkylene group having a carbon number of 4 to 20.