Patents by Inventor Seiji Sakano

Seiji Sakano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1
    Patent number: 7253265
    Abstract: An antibody and a method for producing an antibody that specifically binds to a full length amino acid sequence of human Delta-1.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: August 7, 2007
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Nucleic acid encoding a human serrate-1 polypeptide
    Patent number: 7198918
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: April 3, 2007
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Method of suppressing differentiation by administering a human serrate-1 polypeptide
    Patent number: 7179622
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 20, 2007
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Method of suppressing differentiation by administering a human serrate-1 polypeptide
    Patent number: 7141379
    Abstract: A method for suppressing differentiation of undifferentiated blood cells in vivo by contacting the cells in vitro with a serrate-1 peptide, thereby suppressing differentiation of the cells.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: November 28, 2006
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation-suppressive polypeptide serrate-2 and methods of use
    Patent number: 7138276
    Abstract: A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: November 21, 2006
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Nucleic acids encoding differentiation inhibitor delta 2
    Patent number: 7022499
    Abstract: Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described in SEQ ID NO: 1 of the sequence listing, functions as a chemical useful for proliferation of undifferentiated blood cells and inhibition of differentiation, and hence can be utilized as pharmaceuticals and medical supplies.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: April 4, 2006
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventor: Seiji Sakano
  • Method of suppressing differentiation by administering a human serrate-1 polypeptide
    Publication number: 20050164348
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Application
    Filed: January 27, 2005
    Publication date: July 28, 2005
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Method of suppressing differentiation by administering a human serrate-1 polypeptide
    Publication number: 20050130268
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Application
    Filed: January 27, 2005
    Publication date: June 16, 2005
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Method of suppressing differentiation by administering a human serrate-1 polypeptide
    Publication number: 20050130271
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Application
    Filed: January 27, 2005
    Publication date: June 16, 2005
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Stem cell culture medium and culture method by using the same
    Publication number: 20040023324
    Abstract: A novel culture medium for stem cells. A culture medium containing a human notch ligand protein as the active ingredient and a method of culturing human stem cells by using this medium. The human notch ligand protein may be used together with a growth factor. According to this culture method, the cell count or the frequency of human stem cells having an SRC (Scid Repopulating Cells) activity, human stem cells characterized by being CD34-positive CD38-negative differentiation antigen-negative, etc. can be amplified.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 5, 2004
    Inventors: Seiji Sakano, Mick Bhatia
  • Differentiation inhibitory agent
    Patent number: 6664098
    Abstract: Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described in SEQ ID NO: 1 of the sequence listing, functions as a chemical useful for proliferation of undifferentiated blood cells and inhibition of differentiation, and hence can be utilized as pharmaceuticals and medical supplies.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: December 16, 2003
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventor: Seiji Sakano
  • Differentiation-suppressive polypeptide serrate-2
    Patent number: 6638741
    Abstract: An isolated polypeptide comprising a first amino acid sequence selected from the group consisting of SEQ ID NOs. 1 to 3, and a second amino acid sequence selected from the group consisting of SEQ ID NO. 22 and Fc sequence below hinge region of human IgG, wherein said second amino acid sequence is linked to the C-terminal of said first amino acid sequence.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: October 28, 2003
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Novel differentiation-inhibitor
    Publication number: 20030049788
    Abstract: Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described in SEQ ID NO: 1 of the sequence listing, functions as a chemical useful for proliferation of undifferentiated blood cells and inhibition of differentiation, and hence can be utilized as pharmaceuticals and medical supplies.
    Type: Application
    Filed: September 12, 2002
    Publication date: March 13, 2003
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventor: Seiji Sakano
  • Differentiation-suppressive polypeptide
    Publication number: 20030032781
    Abstract: A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.
    Type: Application
    Filed: August 16, 2002
    Publication date: February 13, 2003
    Applicant: ASAHI KASEI KOGYO KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation-suppressive polypeptide
    Publication number: 20030022368
    Abstract: A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.
    Type: Application
    Filed: August 16, 2002
    Publication date: January 30, 2003
    Applicant: ASAHI KASEI KOGYO KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation-suppressive polypeptide
    Publication number: 20020128197
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the suppression of the proliferation and differentiation of undifferentiated blood cells, this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Application
    Filed: November 29, 2001
    Publication date: September 12, 2002
    Applicant: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation-suppressive polypeptide
    Publication number: 20020049306
    Abstract: A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO:1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.
    Type: Application
    Filed: May 16, 2001
    Publication date: April 25, 2002
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation-suppressive polypeptide
    Patent number: 6337387
    Abstract: A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in the supression of the proliferation and defferentiation of undifferentiated blood cells. this polypeptide is expected to be usable in medicines and medical supplies.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 8, 2002
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Differentiation inhibitor
    Patent number: 6291210
    Abstract: A novel human serrate-2 polypeptide consisting of a polypeptide containing the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing and having the effect of regulating the differentiation of undifferentiated cells involving stem cells; its gene; a process for producing the same; and an antibody specifically recognizing the polypeptide.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: September 18, 2001
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Seiji Sakano, Akira Itoh
  • Tyrosine kinase
    Patent number: 5834208
    Abstract: Disclosed are a novel cytoplasmic tyrosine kinase which is increased with respect to expression amount thereof in accordance with the differentiation of blood cells, and a deoxyribonucleic acid (DNA) coding for the same. The tyrosine kinase of the present invention can be advantageously used for screening chemical substances having the capability to inhibit or activate the tyrosine kinase activity of at least the tyrosine kinase of the present invention.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: November 10, 1998
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventor: Seiji Sakano