Abstract: Conventionally, a coil formed in an irregular shape is used on a distal end side of the coil of a guide wire or a distal joining section is used on the tip of the guide wire to shorten a length in a longitudinal direction of a rigid joint portion for improving the passing performance to the occluded lesion. However, it is not enough especially in the completely occluded lesion. Thus, it is an important technical problem to improve both the passing performance and safety. An outer coil having a coil inclined portion and a distal joining section connected with the coil inclined portion are provided on a distal end portion of the guide wire. In the coil inclined portion, each one turn of a coil wire is continuously inclined in a longitudinal direction. Thus, both the passing performance and safety can be remarkably improved especially in the completely occluded lesion.

Abstract: In a guide wire of the present invention, a distal end portion of a core has a distal small-diameter body and a combined truncated cone including a first truncated cone in order from a distal end side to a proximal end side. A twist angle of the distal small-diameter body is specified to be larger than the twist angle of the first truncated cone to increase flexibility for easily bending at the distal end. At least one truncated cone is connected on the proximal end side of the first truncated cone to form the structure of a combined truncated cone. Thus, the guide wire of the present invention has high rotation transmission performance toward the distal end side and other performances. Accordingly, the guide wire can be quickly reached to the vascular lesion and has high passability at the vascular lesion.

Abstract: In a medical guide wire having a connecting structure formed by three members: a tubular connector; a first core; and a second core, when a torsional rigidity of one member is lower than the torsional rigidity of the materials of both end portions, for example, the twist is unevenly generated between the members and the rotation transmission performance to the distal end side is significantly reduced. In such a case, there is a technical problem for improving the rotation transmission performance to the distal end side. In the connecting structure formed by three members, as a result of focusing on the torsional rigidity of the three members and considering the torsional rigidity ratios between the members, the technical problem for improving the rotation transmission performance to the distal end side can be solved when the torsional rigidity ratios satisfy a predetermined relation.

Abstract: In a medical guide wire having a connecting structure formed by three members: a tubular connector; a first core; and a second core, when a torsional rigidity of one member is lower than the torsional rigidity of the materials of both end portions, for example, the twist is unevenly generated between the members and the rotation transmission performance to the distal end side is significantly reduced. In such a case, there is a technical problem for improving the rotation transmission performance to the distal end side. In the connecting structure formed by three members, as a result of focusing on the torsional rigidity of the three members and considering the torsional rigidity ratios between the members, the technical problem for improving the rotation transmission performance to the distal end side can be solved when the torsional rigidity ratios satisfy a predetermined relation.

Abstract: Conventionally, a coil formed in an irregular shape is used on a distal end side of the coil of a guide wire or a distal joining section is used on the tip of the guide wire to shorten a length in a longitudinal direction of a rigid joint portion for improving the passing performance to the occluded lesion. However, it is not enough especially in the completely occluded lesion. Thus, it is an important technical problem to improve both the passing performance and safety. An outer coil having a coil inclined portion and a distal joining section connected with the coil inclined portion are provided on a distal end portion of the guide wire. In the coil inclined portion, each one turn of a coil wire is continuously inclined in a longitudinal direction. Thus, both the passing performance and safety can be remarkably improved especially in the completely occluded lesion.

Abstract: In a guide wire of the present invention, a distal end portion of a core has a distal small-diameter body and a combined truncated cone including a first truncated cone in order from a distal end side to a proximal end side. A twist angle of the distal small-diameter body is specified to be larger than the twist angle of the first truncated cone to increase flexibility for easily bending at the distal end. At least one truncated cone is connected on the proximal end side of the first truncated cone to form the structure of a combined truncated cone. Thus, the guide wire of the present invention has high rotation transmission performance toward the distal end side and other performances. Accordingly, the guide wire can be quickly reached to the vascular lesion and has high passability at the vascular lesion.

Abstract: A distal end portion 2B of the core has a structure of a combined truncated cone 26 formed by connecting truncated cones satisfying a predetermined relational expression. An outer diameter ratio between the maximum outer diameter and the minimum outer diameter of the combined truncated cone 26 is greater than the outer diameter ratio between a large diameter proximal portion and a small diameter distal portion of an inner coil 4, and is greater than the outer diameter ratio between a large diameter proximal portion and a small diameter distal portion of the outer coil. Because of this, the rotation angle of the proximal side is reduced when rotation operation is performed and the torsional moment toward the distal end side is increased. Thus, the perforation performance at the completely occluded lesion can be improved.

Abstract: A distal end portion 2B of the core has a structure of a combined truncated cone 26 formed by connecting truncated cones satisfying a predetermined relational expression. An outer diameter ratio between the maximum outer diameter and the minimum outer diameter of the combined truncated cone 26 is greater than the outer diameter ratio between a large diameter proximal portion and a small diameter distal portion of an inner coil 4, and is greater than the outer diameter ratio between a large diameter proximal portion and a small diameter distal portion of the outer coil. Because of this, the rotation angle of the proximal side is reduced when rotation operation is performed and the torsional moment toward the distal end side is increased. Thus, the perforation performance at the completely occluded lesion can be improved.

Abstract: An outer coil and an inner coil are joined in parallel with a distal end portion of a core of a guide wire. A winding direction of a strand of the outer coil is the same as that of a strand of the inner coil. Diameters of the outer and inner coils increase or decrease when rotation of the core is transmitted and thereby rotation transmission capability is improved. An outer space wound portion and an inner space wound portion are formed in corresponding positions in the outer coil and the inner coil, respectively, in a core direction. Even if the guide wire has a double-coil structure, the outer and inner space wound portions improve flexibility of the guide wire. A coil pitch of the outer space wound portion differs from a coil pitch of the inner space wound portion. Thereby, engagement of the strands is prevented.

Abstract: An outer coil and an inner coil are joined in parallel with a distal end portion of a core of a guide wire. A winding direction of a strand of the outer coil is the same as that of a strand of the inner coil. Diameters of the outer and inner coils increase or decrease when rotation of the core is transmitted and thereby rotation transmission capability is improved. An outer space wound portion and an inner space wound portion are formed in corresponding positions in the outer coil and the inner coil, respectively, in a core direction. Even if the guide wire has a double-coil structure, the outer and inner space wound portions improve flexibility of the guide wire. A coil pitch of the outer space wound portion differs from a coil pitch of the inner space wound portion. Thereby, engagement of the strands is prevented.

Abstract: A medical guide wire includes a flexible long core. A core elongated component is disposed to extend forwards from the core, and has a tapered shape. A helical coil is disposed about the core elongated component, secured by attachment of a coil distal end and a coil proximal end to the core elongated component. The helical coil includes an equiradial coil portion having the coil proximal end, disposed at a portion of the core elongated component on a side of the core. A diameter decreasing coil portion has the coil distal end, extends forwards from the equiradial coil portion, has a decreasing diameter, and has a length 25 mm or more. A diameter ratio D1/D2 of the diameter decreasing coil portion is 1.22-2.31, where D1 is a proximal end diameter of the diameter decreasing coil portion, and D2 is a distal end diameter of the diameter decreasing coil portion.

Abstract: A medical guide wire includes a flexible long core. A core elongated component is disposed to extend forwards from the core, and has a tapered shape. A helical coil is disposed about the core elongated component, secured by attachment of a coil distal end and a coil proximal end to the core elongated component. The helical coil includes an equiradial coil portion having the coil proximal end, disposed at a portion of the core elongated component on a side of the core. A diameter decreasing coil portion has the coil distal end, extends forwards from the equiradial coil portion, has a decreasing diameter, and has a length 25 mm or more. A diameter ratio D1/D2 of the diameter decreasing coil portion is 1.22-2.31, where D1 is a proximal end diameter of the diameter decreasing coil portion, and D2 is a distal end diameter of the diameter decreasing coil portion.

Abstract: A medical guide wire includes a flexible long core. A core elongated component is disposed to extend forwards from the core, and has a tapered shape. A helical coil is disposed about the core elongated component, secured by attachment of a coil distal end and a coil proximal end to the core elongated component. The helical coil includes an equiradial coil portion having the coil proximal end, disposed at a portion of the core elongated component on a side of the core. A diameter decreasing coil portion has the coil distal end, extends forwards from the equiradial coil portion, has a decreasing diameter, and has a length 25 mm or more. A diameter ratio D1/D2 of the diameter decreasing coil portion is 1.22-2.31, where D1 is a proximal end diameter of the diameter decreasing coil portion, and D2 is a distal end diameter of the diameter decreasing coil portion.

Abstract: A medical guide wire includes a flexible long core. A core elongated component is disposed to extend forwards from the core, and has a tapered shape. A helical coil is disposed about the core elongated component, secured by attachment of a coil distal end and a coil proximal end to the core elongated component. The helical coil includes an equiradial coil portion having the coil proximal end, disposed at a portion of the core elongated component on a side of the core. A diameter decreasing coil portion has the coil distal end, extends forwards from the equiradial coil portion, has a decreasing diameter, and has a length 25 mm or more. A diameter ratio D1/D2 of the diameter decreasing coil portion is 1.22-2.31, where D1 is a proximal end diameter of the diameter decreasing coil portion, and D2 is a distal end diameter of the diameter decreasing coil portion.

Abstract: A rotational handle device rotates a medical instrument for vascular treatment in a tubular form including a tube for insertion by guiding of a medical guide wire inside. The tube includes a helical coil of metal, a tubular tip of metal secured to an end of the helical coil, and a cutting head of a blade shape, formed on the tubular tip, for cutting a lesion upon being rotated. A first rotatable tube rotates with the tube, and has a wire lumen. An externally operable second rotatable tube is secured to the first rotatable tube in an axial direction. An over torque preventing mechanism is disposed between the first and second rotatable tubes, and causes the second rotatable tube to rotate free from the first rotatable tube upon application of torque higher than the predetermined level to the second rotatable tube.

Abstract: A connecting structure of the guide wire used for medical treatment herein consisting of a corrugated tube attached to a main guide wire or an extension wire and a straight bar part formed at the end of said extension wire of said main guide wire wherein said straight bar part is inserted into said corrugated tube to fix elastic deformation resistance produced by both of said corrugated tube and said straight bar part. Said connecting structure of the guide wire can be easily and precisely formed and is not disconnected by the force produced in use but can be disconnected when changed.

Abstract: A treating agent for cellulosic textile materials includes a water-soluble phosphonium salt of phosphorus-containing oxoacid and polycarboxylic acid as active ingredients, and a process of treating cellulosic textile materials uses the treating agent. The treating agent eliminates the necessity of the use of a substance releasing formaldehyde during wash and wear treatment and enables non-formaldehyde wash and wear treatment, and the cellulosic textile material treated by the treating agent is completely free from formaldehyde, retains enough of the strength thereof, and undergoes neither discoloration nor fibrillation.

Abstract: A bifunctional alkyl phosphine oxide which is represented by the following general formula (1), ##STR1## wherein R.sup.1 represents tert-butyl or 1,1,3,3-tetramethylbutyl, and a production method thereof. This organophosphorus compound is useful a wide variety of fields including a flame retardant, antistatic additive, antibacterial agent, dyeing-improving agent, resin modifier, stain-proofing agent, and rust preventives. This compound can be produced industrially advantageously.

Abstract: A monoalkylphosphine represented by the following formula (1): ##STR1## wherein m indicates 1 or 2, and n indicates an integer of 0 to 2. The monoalkylphosphine can effectively be obtained by reaction between phosphine and an alkene in the presence of an organic solvent and an anhydrous alkanesulfonic acid catalyst.

Abstract: An antimicrobial polymer obtained by homo- or copolymerizing a phosphonium salt type vinyl monomer, such as 2-(methacrylic acid) ethyltri-n-octylphosphonium chloride, and a contact lens and an article for its care mainly comprising an antimicrobial resin obtained by copolymerizing a polymerizable monomer and a phosphonium salt type vinyl monomer are disclosed. The antimicrobial polymer has a broad antimicrobial spectrum and produces a sufficient antimicrobial effect after a short contact time. The contact lens and article for its care are hardly effected by contamination with microorganisms while retaining excellent optical performance and processability.