Patents by Inventor Seizo Sato
Seizo Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117390Abstract: To provide a microbial oil that contains eicosapentaenoic acid (EPA) at a high concentration and can effectively exert the function of EPA. A microbial oil containing EPA and docosahexaenoic acid (DHA), in which the content of EPA is 38% by area or greater relative to the total fatty acids and which has at least one fatty acid ratio selected from the group consisting of (a) to (c): (a) a ratio of the content of EPA to the content of DHA of 1.7 or more; (b) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 20 carbon atoms of 0.3 or less; and (c) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 22 carbon atoms of 1.5 or less.Type: ApplicationFiled: December 5, 2023Publication date: April 11, 2024Applicant: Nissui CorporationInventors: Takayoshi SEKIGUCHI, Seizo SATO, Yuko ISHIWATA
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Publication number: 20240011061Abstract: The purpose of the present invention is to provide very long chain polyunsaturated fatty acids and/or derivatives thereof. Substance production of very long chain polyunsaturated fatty acids and/or derivatives thereof has been possible by the conventional technology. However, concentrations of the produced substances have been low. The substance production of very long chain polyunsaturated fatty acids and/or derivatives thereof has been possible. However, the substances produced cannot be obtained in sufficient concentrations and cannot be used as compositions. The present invention provides very long chain polyunsaturated fatty acids and/or derivatives thereof with increased concentrations. Moreover, the object of the present invention is to provide a composition comprising very long chain polyunsaturated fatty acids and/or derivatives thereof.Type: ApplicationFiled: August 4, 2023Publication date: January 11, 2024Applicant: Nissui CorporationInventors: Takayoshi Sekiguchi, Misaki Takahashi, Ryutaro Eko, Seizo Sato
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Patent number: 11856952Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.Type: GrantFiled: April 14, 2022Date of Patent: January 2, 2024Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki Yamaguchi, Yuhei Kosuge, Rie Ikeda, Nobushige Doisaki, Seizo Sato
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Patent number: 11479751Abstract: Provided is a dried powder of microorganisms, which is highly suitable for processing and has excellent usefulness as one component of various products. The present invention provides: a dried powder of microorganisms, the dried powder exhibiting a brightness of 55 or more and a chromaticness of 18 or less; and a method for producing a dried powder of microorganisms, the method comprising: washing microorganisms at least once with a liquid having an osmotic pressure lower than that of a liquid culture medium for culturing the microorganisms; and drying and heating the microorganisms after the washing to thereby obtain the dried powder of the microorganisms, which exhibits a brightness of 55 or more and a chromaticness of 18 or less.Type: GrantFiled: January 31, 2019Date of Patent: October 25, 2022Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Seizo Sato, Takayoshi Sekiguchi, Yuko Ishiwata
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Publication number: 20220248671Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.Type: ApplicationFiled: April 14, 2022Publication date: August 11, 2022Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki YAMAGUCHI, Yuhei KOSUGE, Rie IKEDA, Nobushige DOISAKI, Seizo SATO
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Patent number: 11330817Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.Type: GrantFiled: December 4, 2014Date of Patent: May 17, 2022Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki Yamaguchi, Yuhei Kosuge, Rie Ikeda, Nobushige Doisaki, Seizo Sato
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Publication number: 20220049185Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.Type: ApplicationFiled: October 26, 2021Publication date: February 17, 2022Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki YAMAGUCHI, Nobushige DOISAKI, Seizo SATO, Yuhei KOSUGE
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Patent number: 11193085Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.Type: GrantFiled: February 27, 2018Date of Patent: December 7, 2021Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki Yamaguchi, Nobushige Doisaki, Seizo Sato, Yuhei Kosuge
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Publication number: 20210324433Abstract: The purpose of the present invention is to provide an oil/lipid that contains dihomo-?-linolenic acid at a higher purity. Provided is a microbial oil/lipid that is specified by a high content of dihomo-?-linolenic acid contained therein and/or a reduced content of undesirable constituting fatty acid(s).Type: ApplicationFiled: June 28, 2021Publication date: October 21, 2021Applicant: Nippon Suisan Kaisha, Ltd.Inventors: Seizo SATO, Takayoshi SEKIGUCHI, Misaki TAKAHASHI
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Publication number: 20210047663Abstract: To provide a microbial oil that contains eicosapentaenoic acid (EPA) at a high concentration and can effectively exert the function of EPA. A microbial oil containing EPA and docosahexaenoic acid (DHA), in which the content of EPA is 38% by area or greater relative to the total fatty acids and which has at least one fatty acid ratio selected from the group consisting of (a) to (c): (a) a ratio of the content of EPA to the content of DHA of 1.7 or more; (b) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 20 carbon atoms of 0.3 or less; and (c) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 22 carbon atoms of 1.5 or less.Type: ApplicationFiled: April 26, 2019Publication date: February 18, 2021Applicant: Nippon Suisan Kaisha, Ltd.Inventors: Takayoshi SEKIGUCHI, Seizo SATO, Yuko ISHIWATA
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Publication number: 20210040439Abstract: Provided is a dried powder of microorganisms, which is highly suitable for processing and has excellent usefulness as one component of various products. The present invention provides: a dried powder of microorganisms, the dried powder exhibiting a brightness of 55 or more and a chromaticness of 18 or less; and a method for producing a dried powder of microorganisms, the method comprising: washing microorganisms at least once with a liquid having an osmotic pressure lower than that of a liquid culture medium for culturing the microorganisms; and drying and heating the microorganisms after the washing to thereby obtain the dried powder of the microorganisms, which exhibits a brightness of 55 or more and a chromaticness of 18 or less.Type: ApplicationFiled: January 31, 2019Publication date: February 11, 2021Applicant: Nippon Suisan Kaisha, Ltd.Inventors: Seizo SATO, Takayoshi SEKIGUCHI, Yuko ISHIWATA
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Patent number: 10750741Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.Type: GrantFiled: October 25, 2017Date of Patent: August 25, 2020Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Seizo Sato, Takuro Fukae, Naomi Ohtsuka, Hideaki Yamaguchi, Rie Ikeda
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Patent number: 10597606Abstract: A method for producing monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof, said method involving the following: obtaining free fatty acids or low-grade alcohol esters through the hydrolysis or alcoholysis of oils and fats derived from marine products; carrying out distillation on the free fatty acids or low-grade alcohol esters, and reducing the concentration of fatty acids with 18 or less carbons in the low-grade alcohol esters or free fatty acids; and collecting fractions of monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof by column chromatography based on reversed-phase distribution.Type: GrantFiled: December 29, 2016Date of Patent: March 24, 2020Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Seizo Sato, Takuro Fukae, Naomi Ohtsuka, Hideaki Yamaguchi
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Publication number: 20180187126Abstract: Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.Type: ApplicationFiled: February 27, 2018Publication date: July 5, 2018Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Hideaki YAMAGUCHI, Nobushige DOISAKI, Seizo SATO, Yuhei KOSUGE
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Publication number: 20180042230Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.Type: ApplicationFiled: October 25, 2017Publication date: February 15, 2018Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Seizo SATO, Takuro FUKAE, Naomi OHTSUKA, Hideaki YAMAGUCHI, Rie IKEDA
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Patent number: 9820484Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.Type: GrantFiled: December 4, 2014Date of Patent: November 21, 2017Assignee: NIPPON SUISAN KAISHA, LTD.Inventors: Seizo Sato, Takuro Fukae, Naomi Ohtsuka, Hideaki Yamaguchi, Rie Ikeda
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Publication number: 20170107453Abstract: A method for producing monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof, said method involving the following: obtaining free fatty acids or low-grade alcohol esters through the hydrolysis or alcoholysis of oils and fats derived from marine products; carrying out distillation on the free fatty acids or low-grade alcohol esters, and reducing the concentration of fatty acids with 18 or less carbons in the low-grade alcohol esters or free fatty acids; and collecting fractions of monovalent unsaturated free fatty acids having 20 and/or 22 carbons or low-grade alcohol esters thereof by column chromatography based on reversed-phase distribution.Type: ApplicationFiled: December 29, 2016Publication date: April 20, 2017Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Seizo SATO, Takuro FUKAE, Naomi OHTSUKA, Hideaki YAMAGUCHI
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Publication number: 20170000116Abstract: A microbial oil comprising dihomo-?-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-?-linolenic acid (arachidonic acid/dihomo-?-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-?-linolenic acid or a free fatty acid of dihomo-?-linolenic acid obtained from the microbial oil is provided.Type: ApplicationFiled: December 4, 2014Publication date: January 5, 2017Applicant: NIPPON SUISAN KAISHA, LTD.Inventors: Seizo SATO, Takuro FUKAE, Naomi OHTSUKA, Hideaki YAMAGUCHI, Rie IKEDA
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Publication number: 20160317592Abstract: A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.Type: ApplicationFiled: December 4, 2014Publication date: November 3, 2016Inventors: Hideaki YAMAGUCHI, Yuhei KOSUGE, Rie IKEDA, Nobushige DOISAKI, Seizo SATO
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Publication number: 20160237053Abstract: A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III) or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces, wherein R1, R2, R5 and R6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R1 and R2 or R5 and R6 are bonded; R3, R4, R7 and R8 each independently represent a methyl group or a hydroxymethyl group; and R9 represents a hydrogen atom or a hydroxyl group.Type: ApplicationFiled: March 10, 2016Publication date: August 18, 2016Inventors: Seizo SATO, Fumie IWATA, Shoichi YAMADA, Jiro TAKEO, Akihisa ABE, Hiroyuki KAWAHARA