Patents by Inventor Sen Takeshita
Sen Takeshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9440980Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the ? subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the ? subunit of a trimeric GTP-binding protein, as the active ingredient, etc.Type: GrantFiled: April 25, 2014Date of Patent: September 13, 2016Assignee: EA PHARMA CO., LTD.Inventors: Naoyuki Fukuchi, Satoru Okamoto, Wataru Miyanaga, Sen Takeshita, Masaru Takayanagi, Yumiko Fukuda, Takao Ikenoue, Naoyuki Yamada, Naoko Arashida
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Patent number: 9395376Abstract: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.Type: GrantFiled: December 7, 2010Date of Patent: July 19, 2016Assignee: AJINOMOTO CO., INC.Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino, Naohiro Miyamura, Tomohiko Yamanaka, Hiroaki Nagasaki
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Publication number: 20160137633Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.Type: ApplicationFiled: January 29, 2016Publication date: May 19, 2016Applicant: Ajinomoto Co., Inc.Inventors: Tadakiyo NAKAGAWA, Kayo Matsumoto, Sen Takeshita, Tomomi Yoshida, Munetaka Tokumasu, Hiroki Inoue, Kaori Kobayashi
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Patent number: 9290487Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.Type: GrantFiled: May 2, 2014Date of Patent: March 22, 2016Assignee: AJINOMOTO CO., INC.Inventors: Tadakiyo Nakagawa, Kayo Matsumoto, Sen Takeshita, Tomomi Yoshida, Munetaka Tokumasu, Hiroki Inoue, Kaori Kobayashi
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Publication number: 20160046592Abstract: An object is to provide a novel compound which has a glycogen synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe.Type: ApplicationFiled: October 30, 2015Publication date: February 18, 2016Applicant: Ajinomoto Co., Inc.Inventors: Kayo MATSUMOTO, Wataru MIYANAGA, Mizuki DOHI, Tadakiyo NAKAGAWA, Kaori KOBAYASHI, Sen TAKESHITA
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Publication number: 20140336376Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.Type: ApplicationFiled: May 2, 2014Publication date: November 13, 2014Applicant: Ajinomoto Co., Inc.Inventors: Tadakiyo NAKAGAWA, Kayo Matsumoto, Sen Takeshita, Tomomi Yoshida, Munetaka Tokumasu, Hiroki Inoue, Kaori Kobayashi
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Publication number: 20140309135Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the ? subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the ? subunit of a trimeric GTP-binding protein, as the active ingredient, etc.Type: ApplicationFiled: April 25, 2014Publication date: October 16, 2014Applicant: AJINOMOTO CO., INC.Inventors: Naoyuki FUKUCHI, Satoru Okamoto, Wataru Miyanaga, Sen Takeshita, Masaru Takayanagi, Yumiko Fukuda, Takao Ikenoue, Naoyuki Yamada, Naoko Arashida
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Patent number: 8772281Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the ? subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the ? subunit of a trimeric GTP-binding protein, as the active ingredient, etc.Type: GrantFiled: December 10, 2012Date of Patent: July 8, 2014Assignee: Ajinomoto Co., Inc.Inventors: Naoyuki Fukuchi, Satoru Okamoto, Wataru Miyanaga, Sen Takeshita, Masaru Takayanagi, Yumiko Fukuda, Takao Ikenoue, Naoyuki Yamada, Naoko Arashida
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Patent number: 8357680Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the ? subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the ? subunit of a trimeric GTP-binding protein, as the active ingredient, etc.Type: GrantFiled: October 7, 2009Date of Patent: January 22, 2013Assignee: Ajinomoto Co., Inc.Inventors: Naoyuki Fukuchi, Satoru Okamoto, Wataru Miyanaga, Sen Takeshita, Masaru Takayanagi, Yumiko Fukuda, Takao Ikenoue, Naoyuki Yamada, Naoko Arashida
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Publication number: 20130017548Abstract: The present invention relates to a novel method for screening for a therapeutic or prophylactic agent for an inflammatory disease. More particularly, the present invention relates to a method for screening for a therapeutic or prophylactic agent for an inflammatory disease by selecting a substance having an inhibitory activity specific to PIKfyve by using the presence or absence of the inhibitory activity as an indicator.Type: ApplicationFiled: June 27, 2012Publication date: January 17, 2013Applicant: AJINOMOTO, INC.Inventors: Sen Takeshita, Takashi Yamamoto, Ayatoshi Andou, Tomohisa Okutsu, Agung Eviryanti, Naoyuki Fukuchi, Shunsuke Kageyama
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Patent number: 8173605Abstract: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.Type: GrantFiled: May 8, 2008Date of Patent: May 8, 2012Assignee: Ajinomoto Co., Inc.Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino, Naohiro Miyamura, Tomohiko Yamanaka, Hiroaki Nagasaki
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Patent number: 8106020Abstract: A calcium receptor activator and compositions containing at least one of the following: ?-Glu-Cys-Gly, ?-Glu-Cys(SNO)-Gly, ?-Glu-Ala, ?-Glu-Gly, ?-Glu-Cys, ?-Glu-Met, ?-Glu-Thr, ?-Glu-Val, ?-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, ?-Glu-Met(O), ?-Glu-Val-Val, ?-Glu-Val-Glu, ?-Glu-Val-Lys, ?-Glu-?-Glu-Val, ?-Glu-Val-NH2, ?-Glu-Val-ol, ?-Glu-Ser, ?-Glu-Tau, ?-Glu-Cys(S-Me)(O), ?-Glu-Leu, ?-Glu-Ile, ?-Glu-t-Leu, ?-Glu-Cys(S-allyl)-Gly, ?-Glu-Gly-Gly, ?-Glu-Val-Phe, ?-Glu-Val-Ser, ?-Glu-Val-Pro, ?-Glu-Val-Arg, ?-Glu-Val-Asp, ?-Glu-Val-Met, ?-Glu-Val-Thr, ?-Glu-Val-His, ?-Glu-Val-Asn, ?-Glu-Val-Gln, ?-Glu-Val-Cys, ?-Glu-Val-Orn, ?-Glu-Ser-Gly, ?-Glu-Cys(S-Me), ?-Glu-Abu-Gly, ?-Glu-Cys(S-Me)-Gly, and ?-Glu-Val-Gly.Type: GrantFiled: May 8, 2008Date of Patent: January 31, 2012Assignee: Ajinomoto Co., Inc.Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino
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Publication number: 20110097805Abstract: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.Type: ApplicationFiled: December 7, 2010Publication date: April 28, 2011Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino, Naohiro Miyamura, Tomohiko Yamanaka, Hiroaki Nagasaki
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Publication number: 20100093055Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the ? subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the ? subunit of a trimeric GTP-binding protein, as the active ingredient, etc.Type: ApplicationFiled: October 7, 2009Publication date: April 15, 2010Applicant: AJINOMOTO CO., INC.Inventors: Naoyuki Fukuchi, Satoru Okamoto, Wataru Miyanaga, Sen Takeshita, Masaru Takayanagi, Yumiko Fukuda, Takao Ikenoue, Naoyuki Yamada, Naoko Arashida
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Publication number: 20090239808Abstract: A calcium receptor activator and compositions containing at least one of the following: ?-Glu-Cys-Gly, ?-Glu-Cys(SNO)-Gly, ?-Glu-Ala, ?-Glu-Gly, ?-Glu-Cys, ?-Glu-Met, ?-Glu-Thr, ?-Glu-Val, ?-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, ?-Glu-Met(O), ?-Glu-Val-Val, ?-Glu-Val-Glu, ?-Glu-Val-Lys, ?-Glu-?-Glu-Val, ?-Glu-Val-NH2, ?-Glu-Val-ol, ?-Glu-Ser, ?-Glu-Tau, ?-Glu-Cys(S-Me)(O), ?-Glu-Leu, ?-Glu-Ile, ?-Glu-t-Leu, ?-Glu-Cys(S-allyl)-Gly, ?-Glu-Gly-Gly, ?-Glu-Val-Phe, ?-Glu-Val-Ser, ?-Glu-Val-Pro, ?-Glu-Val-Arg, ?-Glu-Val-Asp, ?-Glu-Val-Met, ?-Glu-Val-Thr, ?-Glu-Val-His, ?-Glu-Val-Asn, ?-Glu-Val-Gln, ?-Glu-Val-Cys, ?-Glu-Val-Orn, ?-Glu-Ser-Gly, ?-Glu-Cys(S-Me), ?-Glu-Abu-Gly, ?-Glu-Cys(S-Me)-Gly, and ?-Glu-Val-Gly.Type: ApplicationFiled: May 8, 2008Publication date: September 24, 2009Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino
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Publication number: 20090239310Abstract: The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink imparted with kokumi, and food or drink imparted with kokumi.Type: ApplicationFiled: May 8, 2008Publication date: September 24, 2009Inventors: Takeaki Ohsu, Sen Takeshita, Yuzuru Eto, Yusuke Amino, Naohiro Miyamura, Tomohiko Yamanaka, Hiroaki Nagasaki
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Publication number: 20080182811Abstract: Amino acids other than glutamic acid are used as a metabotropic glutamate receptor activator. More preferably, aspartic acid, valine and cysteine are used as a group I metabotropic glutamate receptor activator; alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, ornithine, taurine and hydroxyproline are used as a group II metabotropic glutamate receptor activator; and cysteine is used as a group III metabotropic glutamate receptor activator.Type: ApplicationFiled: December 21, 2007Publication date: July 31, 2008Applicant: Ajinomoto Co., Inc.Inventors: Takeaki Ohsu, Sen Takeshita, Mitsuo Takahashi, Yuzuru Eto
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Publication number: 20070037886Abstract: Bone marrow erythroid progenitor cell(s) differentiation may be induced and anemia may be treated by administering arginine. Arginine is an excellent differentiation inducer, because it has high safety, can be orally administered, and is widely used.Type: ApplicationFiled: April 26, 2006Publication date: February 15, 2007Applicant: Ajinomoto Co., Inc.Inventors: Sen Takeshita, Yuzuru Eto, Yoshiyuki Takahara, Kiyonobu Kamiya, Kazumi Tashiro, Maki Sugiyama, Hiroshi Yamamoto
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Publication number: 20060257935Abstract: The present invention provides methods of screening for enhancers and/or inhibitors of a hematopoietic factor production promoter comprising arginine as an active ingredient. Arginine is an excellent hematopoietic factor production promoter, because it has high safety, can be orally administered, and is widely used.Type: ApplicationFiled: April 26, 2006Publication date: November 16, 2006Applicant: Ajinomoto Co., Inc.Inventors: Sen Takeshita, Yuzuru Eto, Yoshiyuki Takahara, Kiyonobu Kamiya, Kazumi Tashiro, Maki Sugiyama, Hiroshi Yamamoto