Abstract: Provided is a method of manufacturing healthy drink using Opuntia ficus-indica, which includes the steps of: removing fruits and thorns from stems of the Opuntia ficus-indica, washing the stems of the Opuntia ficus-indica, and mixing and grinding 90% to 99.5% by weight of the washed stems of the Opuntia ficus-indica and 0.5% to 10% by weight of roasted ginkgo nuts to thereby prepare a crude liquid of mixed materials; mixing 50% to 60% by weight of the crude liquid of mixed materials and 40% to 50% by weight of water; ripening and filtering the diluted crude liquid for 12 hours to 24 hours at temperature of 60° C. to 80° C.; mixing 0.2% to 1% by weight of at least one of pure crystalline fructose and fructooligosaccharine to 99% to 99.8% by weight of the filtered crude liquid; and sterilizing the crude liquid.