Patents by Inventor Ser-Mien Chia

Ser-Mien Chia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-layer cell encapsulation for tissue engineering
    Patent number: 7943353
    Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: May 17, 2011
    Assignees: Agency for Science, Technology and Research, The National University of Singapore
    Inventors: Hanry Yu, Kam W Leong, Ser-Mien Chia, Andrew C. A. Wan
  • MULTI-LAYER CELL ENCAPSULATION FOR TISSUE ENGINEERING
    Publication number: 20090286278
    Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
    Type: Application
    Filed: July 23, 2009
    Publication date: November 19, 2009
    Applicants: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Hanry Yu, Kam W. Leong, Ser-Mien Chia, Andrew C.A. Wan
  • Multi-layer cell encapsulation for tissue engineering
    Publication number: 20050220891
    Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
    Type: Application
    Filed: May 26, 2005
    Publication date: October 6, 2005
    Applicants: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Hanry Yu, Kam Leong, Ser-Mien Chia, Andrew Wan
  • Multi-layer cell encapsulation for tissue engineering
    Patent number: 6916640
    Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: July 12, 2005
    Assignees: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Hanry Yu, Kam W. Leong, Ser-Mien Chia, Andrew C. A. Wan
  • Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells
    Patent number: 6905875
    Abstract: A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: June 14, 2005
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Hanry Yu, Kam W. Leong, Ser-Mien Chia
  • Non-disruptive three-dimensional culture and harvest system for anchorage-dependent cells
    Publication number: 20040023370
    Abstract: A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.
    Type: Application
    Filed: August 22, 2003
    Publication date: February 5, 2004
    Inventors: Hanry Yu, Kam Leong, Ser-Mien Chia
  • Multi-layer cell encapsulation for tissue engineering
    Publication number: 20020094569
    Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.
    Type: Application
    Filed: October 12, 2001
    Publication date: July 18, 2002
    Inventors: Hanry Yu, Kam W. Leong, Ser-Mien Chia, Andrew C.A. Wan