Abstract: Systems and method for performing transfers non-fungible tokens (NFT). For instance, the system includes a first blockchain module of a first blockchain technology; a second blockchain module of a second blockchain technology; an integration module configured to store computer executable instructions for communicating with a plurality of blockchain technologies including the first and second blockchain technologies. The system withdraws the NFT from the first blockchain module; locks the NFT on the first blockchain module; deposits the NFT to the second blockchain module; unlocks the NFT on the second blockchain module; and records the transfer of the NFT on the first or second blockchain module.

Abstract: A pharmaceutical composition comprising a compound and/or a pharmaceutically acceptable salt thereof having the following Formula I is disclosed: wherein R1, R2, R3, and R4 are as defined herein. Also, a method of treating an individual suffering from multiple myeloma, leukemia or lymphoma and method of preparing a compound of Formula I are disclosed. These compounds can be PIKfyve kinase inhibitors.

Abstract: A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

Abstract: A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

Abstract: A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

Abstract: A compound and/or a pharmaceutically acceptable salt thereof has the following formula A: These compounds can be PIKfyve kinase inhibitors.

Abstract: This application provides methods of determining biological activities of a biological sample comprising, for example, comparing the profile of transcription factor activities in a cell contacted with the biological sample to a control profile, such as a profile of transcription factor activities in a cell not contacted with the biological sample.

Abstract: Compositions, methods and kits are provided that are useful, for example, for determining activities of multiple cis-regulatory sequences, such as promoters and enhancers, and/or multiple trans-acting factors, such as transcription factors, in a cell. In particular, in certain embodiments, compositions are provided comprising a population of polynucleotide reporter transcription units (RTUs) in which each RTU comprises a reporter sequence, a processing tag located in the reporter sequence; and a cis-regulatory element operably linked to the reporter sequence, wherein the reporter sequences between any two RTUs in the population, outside of the processing tags, are substantially identical and wherein the positions of the processing tags within the reporter sequences distinguish between any two RTUs differing, for example, in their cis-regulatory elements. The compositions, methods and kits can further be used, for example, to identify a cell type or disease state, for example, in a biological organism.