Patents by Inventor Sergio A. Castillo
Sergio A. Castillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11814673Abstract: The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.Type: GrantFiled: August 1, 2012Date of Patent: November 14, 2023Assignee: GENinCode PLCInventors: Eduardo Salas Pérez-Rasilla, Jaume Marrugat De La Iglesia, Roberto Elosua Llanos, Sergio Castillo Fernandez, Joan Salgado Gomez, José Maria Ordovás Munoz
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Publication number: 20200202804Abstract: The disclosure relates to displays. In one arrangement a plurality of pixels are provided. Each pixel comprises a first optical element reversibly switchable between at least two optical states, and a second optical element reversibly switchable between at least two optical states. The first optical element overlaps spatially with the second optical element in an overlap region when viewed from a viewing side of the display, such that an overall optical effect for the overlap region is defined by a combination of the optical state of the first optical element and the optical state of the second optical element. Row signal lines and column signal lines allow individual addressing of each pixel by applying a combination of a row control signal and a column control signal to the pixel. A driving controller applies the row control signals and the column control signals to the pixels.Type: ApplicationFiled: June 15, 2018Publication date: June 25, 2020Inventors: SERGIO CASTILLO GARCIA, BEN BROUGHTON, PEIMAN HOSSEINI, CLEMENT TALAGRAND
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Patent number: 10557170Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: GrantFiled: July 17, 2017Date of Patent: February 11, 2020Assignee: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua Llanos, Joan Vila, Sergio Castillo Fernandez
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Patent number: 10023914Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: GrantFiled: October 19, 2015Date of Patent: July 17, 2018Assignee: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua, Joan S. Vila, Sergio Castillo
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Patent number: 9957565Abstract: The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.Type: GrantFiled: June 9, 2010Date of Patent: May 1, 2018Assignee: Gendiag.exe, S.L.Inventors: Eduardo Salas Pérez-Rasilla, Jaume Marrugat De La Iglesia, Roberto Elosua Llanos, Sergio Castillo Fernandez, Joan Salgado Gómez, Jose Maria Ordovás Munoz
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Publication number: 20180066313Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: July 17, 2017Publication date: March 8, 2018Applicant: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua Llanos, Joan Vila, Sergio Castillo Fernandez
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Patent number: 9518297Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: GrantFiled: June 13, 2012Date of Patent: December 13, 2016Assignee: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua Llanos, Joan Vila, Sergio Castillo
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Publication number: 20160215341Abstract: The invention relates to a method for determining the risk of a subject suffering from chronic kidney disease of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with clinical/biochemical risk factors for CVD as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: August 29, 2014Publication date: July 28, 2016Applicant: Gendiag.exe, S.L.Inventors: Eduardo Salas, Sara Pich, Manuel Arias, Roberto Elosua, Sergio Castillo
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Publication number: 20160102355Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: October 19, 2015Publication date: April 14, 2016Applicant: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua Llanos, Joan Vila, Sergio Castillo Fernandez
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Publication number: 20140342355Abstract: The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: August 1, 2012Publication date: November 20, 2014Applicant: Gendiag.exe, S.L.Inventors: Eduardo Salas Pérez-Rasilla, Jaume Marrrugat De La Iglesia, Roberto Elosua Llanos, Sergio Castillo Fernández, Joan Salgado Gómez, José Maria Ordovás Munoz
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Publication number: 20140221230Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: June 13, 2012Publication date: August 7, 2014Applicant: Gendiag.exe, S.L.Inventors: Eduardo Salas, José Manuel Soria, Miroslava Ogorelkova, Roberto Elosua Llanos, Joan Vila, Sergio Castillo
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Patent number: 8669049Abstract: The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.Type: GrantFiled: January 21, 2004Date of Patent: March 11, 2014Assignee: Progenika Biopharma, S.A.Inventors: Pedro Mata Lopez, Rodrigo Alberto Alonso Karlezi, Pilar Mozas Alonso, Gilberto Reyes Leal, Miguel Pocovi Mieras, Sergio Castillo Fernandez, Diego Tejedor Hernandez, Antonio Martinez Martinez, Miguel Mallen Perez
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Publication number: 20120141450Abstract: The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.Type: ApplicationFiled: June 9, 2010Publication date: June 7, 2012Applicant: GENDIAG.EXE, S.L.Inventors: Eduardo Salas Pérez-Rasilla, Jaume Marrugat De La Iglesia, Roberto Elosua Llanos, Sergio Castillo Fernandez, Joan Salgado Gómez, Jose Maria Ordovás Munoz
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Patent number: 6554249Abstract: The invention is directed to a plug valve comprising a body which includes an inlet port, an outlet port and a cavity that is connected between the inlet and outlet ports; first and second seal segments which are mounted in the cavity and which each comprise a through bore that is coaxial with the inlet and outlet ports; the through bores and the inlet and outlet ports defining a flow passage through the body; a plug member which is rotatably positioned between the first and second seal segments and which includes a hole that extends transversely therethrough; the plug member being rotatable between an open position in which the hole is aligned with the flow passage and a closed position in which the hole is offset from the flow passage; and at least a first booster spring which is positioned between the first seal segment and the body to bias the first seal segment against the plug member.Type: GrantFiled: May 30, 2001Date of Patent: April 29, 2003Assignee: FMC Technologies, Inc.Inventors: Rick Wei-Shou Pang, Tep Ungchusri, Sergio Castillo
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Publication number: 20020179876Abstract: The invention is directed to a plug valve comprising a body which includes an inlet port, an outlet port and a cavity that is connected between the inlet and outlet ports; first and second seal segments which are mounted in the cavity and which each comprise a through bore that is coaxial with the inlet and outlet ports; the through bores and the inlet and outlet ports defining a flow passage through the body; a plug member which is rotatably positioned between the first and second seal segments and which includes a hole that extends transversely therethrough; the plug member being rotatable between an open position in which the hole is aligned with the flow passage and a closed position in which the hole is offset from the flow passage; and at least a first booster spring which is positioned between the first seal segment and the body to bias the first seal segment against the plug member.Type: ApplicationFiled: May 30, 2001Publication date: December 5, 2002Inventors: Rick Wei-Shou Pang, Tep Ungchusri, Sergio Castillo
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Patent number: 6371527Abstract: The present invention is directed to a swivel joint for fluid conduits which comprises a central axis; a tubular male member having an outer annular surface, a first end and at least first and second outer annular grooves formed on the outer surface coaxial with the central axis; a tubular female member having an inner annular recess, an annular shoulder formed at an inner end of the recess and at least first and second inner annular grooves formed on the recess coaxial with the central axis; wherein the outer surface of the male member is adapted to be received in the recess of the female member such that the first end is disposed proximate the shoulder and each outer groove is aligned with a corresponding inner groove to thereby define at least first and second annular races; a plurality of balls disposed in each race to secure said male and female members together and to facilitate relative rotation of the male and female members about the central axis; wherein the radius of each race as measured from theType: GrantFiled: November 1, 2000Date of Patent: April 16, 2002Assignee: FMC CorporationInventors: Tep Ungchusri, Sergio A. Castillo
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Patent number: 6164707Abstract: A fluid-carrying swivel joint has a stepped bearing race arrangement on interconnecting hubs having an improved bore seal capability. The stepped arrangement allows more ball bearings per adjacent race which allows equal distribution of hydrostatic end loading to each bearing race, thereby enabling maximum total end loading while minimizing load concentration on a particular bearing race section due to increased total ball and race contact area. A straight bore type seal is used to reduce surface area subject to axial pressure and to minimize rotational friction.Type: GrantFiled: November 1, 1996Date of Patent: December 26, 2000Assignee: FMC CorporationInventors: Tep Ungchusri, Sergio A. Castillo
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Patent number: 5931476Abstract: A bore seal assembly for sealing between first and second adjoining tubular members which comprises a cylindrical seal sleeve having a bore and two radially outwardly extending sealing lips for engaging a seal pocket formed in the adjoining ends of the first and second tubular members, a cylindrical wear sleeve mounted within the bore for supporting the seal sleeve within the seal pocket, and an elongated erosion sleeve extending longitudinally from the wear sleeve into at least the first tubular member, whereby the erosion sleeve protects the first tubular member against erosion.Type: GrantFiled: January 23, 1997Date of Patent: August 3, 1999Assignee: FMC CorporationInventors: Tep Ungchusri, Sergio A. Castillo, Jr.
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Patent number: RE39695Abstract: A swivel joint comprises a tubular male member having at least first and second outer annular grooves formed on an outer surface, a tubular female member having at least first and second inner annular grooves formed on an inner recess, and a plurality of balls disposed in at least first and second annular races which are formed by the alignment of the first and second outer grooves with the first and second inner grooves when a first end of the male member is received within the recess of the female member. In addition, the radius of the first race is greater than the radius of an adjacent race closer to the first end of the male member, and the number of balls in the first race is just one more than the number of balls in the adjacent race closer to the first end.Type: GrantFiled: March 11, 2003Date of Patent: June 19, 2007Assignee: FMC Technologies, Inc.Inventors: Tep Ungchusri, Sergio A. Castillo
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Patent number: D1023749Type: GrantFiled: August 16, 2022Date of Patent: April 23, 2024Assignee: The Procter & Gamble CompanyInventors: Luke Anthony Snider, Folke Schlueter, Sergio Ricardo Lopez Manzano, Macarena Castillo Olmos