Patents by Inventor Sergio A Paulo
Sergio A Paulo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240180486Abstract: The present disclosure relates to a portable system for the progressive aerobic cardiovascular endurance run test of a subject and method thereof. The portable system of the present disclosure comprises a strip comprising an interface configured for receiving input data from a user, sending instructions to a controller, and displaying data; a controller configured for receiving instructions from the interface, controlling a plurality of light emitters, and sending data to the interface; and, a variable length strip defining a length of the running path and connected to the controller comprising a plurality of light emitters for emitting a light signal to the subject. Wherein the input data are the test parameters of the progressive aerobic cardiovascular endurance run test and the lap counts at each stage, and wherein the light signal is a light pattern that, at a pre-determined pace, changes a state of a light emitter in the sequence of the running direction.Type: ApplicationFiled: November 29, 2022Publication date: June 6, 2024Applicant: IPVC | Instituto Politécnico de Viana do CasteloInventors: Sérgio Ivan FERNANDES LOPES, Luís Paulo RODRIGUES, João Miguel DE OLIVEIRA PASSOS, Filipe CLEMENTE, José Pedro BEZERRA, Pedro Miguel DO VALE MOREIRA
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Publication number: 20210386858Abstract: Provided herein are compositions, which may be useful for mucosal delivery of active agents. The provided compositions may be useful for treating diseases.Type: ApplicationFiled: February 18, 2020Publication date: December 16, 2021Applicant: BLUEPHARMA - INDUSTRIA FARMACÊUTICA, S.A.Inventors: Francisca Bastos Silva, António Lucas Nunes, Cláudia Sousa Silva, Sérgio Paulo Simões
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Publication number: 20200384097Abstract: The invention provides a composition comprising a reduced toxicity NetB epitope polypeptide and a reduced toxicity Clostridium perfringens alpha-toxin epitope polypeptide. The composition is useful as a vaccine providing complete protection against infection by C. perfringens.Type: ApplicationFiled: August 19, 2020Publication date: December 10, 2020Inventors: Richard William Titball, Sergio Paulo Fernandes Da Costa, Filip Van Immerseel, Richard Ducatelle, Dorien Mot
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Patent number: 10174086Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: GrantFiled: August 22, 2016Date of Patent: January 8, 2019Assignee: University of ExeterInventors: Richard W. Titball, Sergio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Patent number: 9670217Abstract: The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacteriochlorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalies that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.Type: GrantFiled: October 22, 2009Date of Patent: June 6, 2017Assignee: UNIVERSIDADE DE COIMBRAInventors: Luis Guilherme Da Silva Arnaut Moreira, Maria Miguéns Pereira, Sebastião José Formosinho SanchesSimõs, Sérgio Paulo Magalhães Simões, Grazyna Stochel, Krystyna Urbanska
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Patent number: 9603935Abstract: Described herein are orodispersible films comprising a film forming hydrophobic polymer, a disintegrant, a plasticizer and a stabilizer.Type: GrantFiled: July 31, 2014Date of Patent: March 28, 2017Assignee: BluepharmaInventors: Ana Filipa Silva Borges, Branca Margarida Almeida Silva, Jorge Fernando Jordao Coelho, Claudia Sousa Silva, Sergio Paulo Simoes
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Publication number: 20170051023Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: ApplicationFiled: August 22, 2016Publication date: February 23, 2017Applicant: University of ExeterInventors: Richard W. Titball, Sergio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Publication number: 20160310587Abstract: The invention provides a composition comprising a reduced toxicity NetB epitope polypeptide and a reduced toxicity Clostridium perfringens alpha-toxin epitope polypeptide. The composition is useful as a vaccine providing complete protection against infection by C. perfringens.Type: ApplicationFiled: December 18, 2014Publication date: October 27, 2016Inventors: Richard William Titball, Sergio Paulo Fernandes Da Costa, Filip Van Immerseel, Richard Ducatelle, Dorien Mot
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Patent number: 9422343Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: GrantFiled: October 24, 2012Date of Patent: August 23, 2016Assignee: University of ExeterInventors: Richard W. Titball, Sérgio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Patent number: 9287485Abstract: Method for joining wires using low resistivity joints is provided. More specifically, methods of joining one or more wires having superconductive filaments, such as magnesium diboride filaments, are provided. The wires are joined by a low resistivity joint to form wires of a desired length for applications, such in medical imaging applications.Type: GrantFiled: March 9, 2012Date of Patent: March 15, 2016Assignee: General Electric CompanyInventors: Judson Sloan Marte, Xianrui Huang, Evangelos Trifon Laskaris, Bruce Alan Knudsen, Thomas Robert Raber, Robert John Zabala, James William Bray, Paul Shadforth Thompson, Sergio Paulo Martins Loureiro, Curtis Alan Johnson, Sylvia Marie Decarr
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Publication number: 20150306049Abstract: The invention relates to pharmaceutical compositions comprising: (a) from 15 to 50% by weight cinacalcet HCl; (b) from 30 to 80% by weight of one or more fillers; (c) from 5.1% to 7% by weight of one or more binders; and optionally one or more disintegrants, one or more glidants and/or one or more lubricants or one or more other acceptable pharmaceutical excipients and to a manufacturing process for the manufacture of such pharmaceutical compositions.Type: ApplicationFiled: November 6, 2013Publication date: October 29, 2015Applicant: K.H.S. PHARMA HOLDING GMBHInventors: Stephanie Cadonau, Christian Drescher, Gabriel Leitao Silva, Sérgio Paulo Simoes
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Publication number: 20150038594Abstract: Described herein are orodispersible films comprising a film forming hydrophobic polymer, a disintegrant, a plasticizer and a stabilizer.Type: ApplicationFiled: July 31, 2014Publication date: February 5, 2015Applicant: BluepharmaInventors: Ana Filipa Silva Borges, Branca Margarida Almeida Silva, Jorge Fernando Jordao Coelho, Claudia Sousa Silva, Sergio Paulo Simoes
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Publication number: 20140302094Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: ApplicationFiled: October 24, 2012Publication date: October 9, 2014Applicant: UNIVERSITY OF EXETERInventors: Richard W. Titball, Sérgio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Patent number: 8741338Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: GrantFiled: September 6, 2013Date of Patent: June 3, 2014Assignees: Universidade de Comibra, Centro de Neurociencias e Biologia CelularInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sergio Paulo de Magalhães Simões, Maria da Conceição Monteiro Pedroso de Lima
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Publication number: 20140004042Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: ApplicationFiled: September 6, 2013Publication date: January 2, 2014Applicants: Centro de Neurociencias e Biologia Celular, Universidade de CoimbraInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sergio Paulo de Magalhães Simões, Maria de Conceição Monteiro Pedroso de Lima
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Patent number: 8529944Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: GrantFiled: May 9, 2012Date of Patent: September 10, 2013Assignees: Universidade de Coimbra, Centro de Neurociencias e Biologia CelularInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sergio Paulo de Magalhães Simões, Maria da Conceição Monteiro Pedroso de Lima
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Patent number: 8419974Abstract: Disclosed here are methods for the preparation of optionally activated nanocrystalline rare earth phosphates. The optionally activated nanocrystalline rare earth phosphates may be used as one or more of quantum-splitting phosphor, visible-light emitting phosphor, vacuum-UV absorbing phosphor, and UV-emitting phosphor. Also disclosed herein are discharge lamps comprising the optionally activated nanocrystalline rare earth phosphates provided by these methods.Type: GrantFiled: December 11, 2008Date of Patent: April 16, 2013Assignee: General Electric CompanyInventors: Holly Ann Comanzo, Mohan Manoharan, Sergio Paulo Martins Loureiro, Anant Achyut Setlur, Alok Mani Srivastava
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Publication number: 20120282172Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: ApplicationFiled: May 9, 2012Publication date: November 8, 2012Applicants: Centro de Neurociencias e Biologia Celular, Universidade de CoimbraInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sérgio Paulo de Magalhães Simões, Maria da Conceição Monteiro Pedroso de Lima
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Patent number: 8231895Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: GrantFiled: May 22, 2008Date of Patent: July 31, 2012Assignees: Universidade de Coimbra, Centro de Neurociencias e Biologia CelularInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sérgio Paulo de Magalhães Simões, Maria da Conceição Monteiro Pedroso de Lima
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Patent number: 8211498Abstract: In some embodiments, the present invention is directed to methods of making structures with complex functional architectures, where such structures generally comprise at least two mesoporous regions comprising different chemical activity, and where such methods afford spatial control over the placement of such regions of differing chemical activity. In some embodiments, the present invention is also directed to the structures formed by such methods, where such structures are themselves novel.Type: GrantFiled: June 12, 2009Date of Patent: July 3, 2012Assignee: General Electric CompanyInventors: Anthony Yu-Chung Ku, Seth Thomas Taylor, Mohan Manoharan, Sergio Paulo Martins Loureiro, James Anthony Ruud