Abstract: Methods of predicting the response of a subject to chimeric antigen receptor (CAR) therapy comprising receiving peripheral blood smears (PBS) from the subject and determining the number of CAR cells in the PBS are provided.

Abstract: A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.

Abstract: A microscope system for detecting a scan area within hematology slides in digital microscopy may include a scanning apparatus to scan a hematology sample, and a processor coupled to the scanning apparatus and a memory. The processor may be configured to execute instructions which may cause the system to receive a first image of the sample at a first resolution and determine a scan area of the sample to scan in response to the first image. The instructions may further cause the system to scan the scan area to generate an image of the scan area at a second resolution greater than the first resolution and classify a plurality of cells from the image of the scan area into cell data comprising a plurality of cell parameters. The instructions may also cause the microscope system to output the cell data. Various other systems and methods are provided.

Abstract: A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.