Patents by Inventor Shahid Zaman

Shahid Zaman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic methods for drug screening for Alzheimer's disease
    Patent number: 6960470
    Abstract: Methods of screening candidate drugs for the treatment of Alzheimer's disease are provided. Employing tissue slices of mutant mouse hippocampal cells having an extra copy of a mutant form of the presenilin-1 gene, it is found that these cells have enhanced potentiation to tetanic stimuli. By subjecting both wild-type and mutant hippocampal cells to tetanic stimuli in the presence of a candidate drug, reduction of the enhanced potentiation of the mutant cells without significant change in the potentiation of the wild-type cells indicates a successful candidate.
    Type: Grant
    Filed: July 14, 1999
    Date of Patent: November 1, 2005
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Roberto Malinow, Shahid Zaman, Sangram S. Sisodia, David R. Borchelt, Michael K. Lee