Patents by Inventor Shai Nimri
Shai Nimri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11480565Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.Type: GrantFiled: June 12, 2020Date of Patent: October 25, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Shai Nimri, Yochanan Uri, Boaz Ran
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Publication number: 20210389305Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.Type: ApplicationFiled: June 12, 2020Publication date: December 16, 2021Inventors: Shai NIMRI, Yochanan URI, Boaz RAN
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Patent number: 10732178Abstract: The present invention is directed to novel assays for detecting target molecules. The assays employ small size, detectably labeled, magnetic nanoparticles associated with a capture molecule. The detection assay is accelerated by applying magnetic field during the assay. The assays of the invention can be used to enhance the efficiency of the detection step in dot blot, Western blot and ELISA.Type: GrantFiled: January 29, 2014Date of Patent: August 4, 2020Assignee: BIO-RAD HAIFA LTD.Inventors: Shai Nimri, Vered Bronner
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Patent number: 10359397Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.Type: GrantFiled: December 14, 2015Date of Patent: July 23, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Yochanan Uri, Uri Issman, Igor Kochetkov, Itay Barak, Shai Aharon, Shai Nimri
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Publication number: 20160299099Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.Type: ApplicationFiled: December 14, 2015Publication date: October 13, 2016Inventors: Yochanan Uri, Uri Issman, Igor Kochetkov, Itay Barak, Shai Aharon, Shai Nimri
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Patent number: 9175421Abstract: Provided is a method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method includes adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. Also provided is a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: GrantFiled: December 21, 2011Date of Patent: November 3, 2015Assignee: Bio-Rad Haifa Ltd.Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ariel Lipson, Ran Boaz, Doron Lipson, Yaakov Levie
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Patent number: 9040309Abstract: The invention provides a binding layer comprising a polysaccharide substituted by carboxylic groups or derivatives thereof exhibiting high performance in the binding of ligand molecules and in the interaction thereof with analyte molecules. A method for the preparation of the binding layer and for the assaying of various analyte molecules is also provided.Type: GrantFiled: June 21, 2006Date of Patent: May 26, 2015Assignee: BIO-RAD HAIFA LTD.Inventor: Shai Nimri
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Publication number: 20140212990Abstract: The present invention is directed to novel assays for detecting target molecules. The assays employ small size, detectably labeled, magnetic nanoparticles associated with a capture molecule. The detection assay is accelerated by applying magnetic field during the assay. The assays of the invention can be used to enhance the efficiency of the detection step in dot blot, Western blot and ELISA.Type: ApplicationFiled: January 29, 2014Publication date: July 31, 2014Applicant: BIO-RAD Haifa Ltd.Inventors: Shai NIMRI, Vered BRONNER
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Publication number: 20120129723Abstract: Provided is a method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method includes adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. Also provided is a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: ApplicationFiled: December 21, 2011Publication date: May 24, 2012Applicant: BIO-RAD HAIFA LTD.Inventors: Ariel NOTCOVICH, Alon HERSCHHORN, Shai NIMRI, John BARICH, Ariel LIPSON, Ran BOAZ, Doron LIPSON, Yaakov LEVIE
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Patent number: 8105845Abstract: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. The invention also provides a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: GrantFiled: November 14, 2004Date of Patent: January 31, 2012Assignee: Bio-Rad Haifa Ltd.Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ariel Lipson, Ran Boaz, Doron Lipson, Yaakov Levie
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Publication number: 20070117199Abstract: The invention provides a binding layer comprising a polysaccharide substituted by carboxylic groups or derivatives thereof exhibiting high performance in the binding of ligand molecules and in the interaction thereof with analyte molecules. A method for the preparation of the binding layer and for the assaying of various analyte molecules is also provided.Type: ApplicationFiled: June 21, 2006Publication date: May 24, 2007Inventor: Shai Nimri
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Publication number: 20070087348Abstract: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at each of the microspots, there being a plurality of combinations of first binding member surface density and second binding member concentration among the plurality of microspots. Data indicative of a binding reaction between the first of microspots are then obtained and analyzed so as to obtain one or more kinetic parameters of the binding between the first and second binding members. The invention also provides a system for carrying out the method. A method for localizing a molecular species at microspots on a surface, and a probe array produced by the method are also provided.Type: ApplicationFiled: November 14, 2004Publication date: April 19, 2007Inventors: Ariel Notcovich, Alon Herschhorn, Shai Nimri, John Barich, Ran Boaz, Doron Lipson, Yaakov Levie
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Publication number: 20040015101Abstract: The invention relates to a non-invasive method for the diagnosis of cardiovascular disease in a subject, comprising the steps of measuring in a urine sample the concentrations of one or more thromboxanes, the conductivity, and the concentration of at least one additional marker of cardiovascular disease, which marker can be chosen from apolipoprotein (a), conjugated dienes and lipid peroxides. Diagnosing the presence of cardiovascular disease in said subject is carried out by comparison of the analytical results with pre-determined reference values. The invention further relates to a kit for the rapid diagnosis of cardiovascular diseases.Type: ApplicationFiled: January 13, 2003Publication date: January 22, 2004Inventors: Yoram Rubin, Shai Nimri, Nitsa Galili-Nachshon, Sari Alon, Inbal Ben-Tzvi Tzchori
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Publication number: 20030171698Abstract: The invention relates to a method for the diagnosis of a medical condition in a subject, comprising the steps of measuring the concentration of one or more analytes, relevant for the diagnosis of said medical condition, in a urine sample; measuring the electrical conductivity of said urine sample; obtaining a normalized value for the analyte concentration by dividing said analyte concentration by the electrical conductivity; and determining whether said subject is suffering from said medical condition by means of comparing the normalized value with a pre-determined reference value. The medical condition to be diagnosed can be, for example, an acute cardiac condition for which the relevant urinary analyte can be one or more thromboxanes.Type: ApplicationFiled: January 13, 2003Publication date: September 11, 2003Inventors: Yoram Rubin, Shai Nimri, Nitsa Galili-Nachshon, Sari Alon, Inbal Ben-Tzi Tzchori
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Publication number: 20020038762Abstract: The present invention relates to solid-state ion selective electrodes (ISEs), methods of producing same and devices containing same. The electrodes include: (a) an internal reference element which includes a homogenous conducting body; (b) a solid contact which includes a hydrophobic polymer, an ionophore and particles of conductive material and (c) an ion selective membrane which includes a hydrophobic polymer and an ionophore. The particles of conductive material are dispersed throughout the hydrophobic polymer of the solid contact.Type: ApplicationFiled: February 7, 2001Publication date: April 4, 2002Applicant: ADVANCED MONITORING SYSTEMS LTD.Inventors: Irina Eventov, Shai Nimri