Patents by Inventor Shang-Tian Yang
Shang-Tian Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10150951Abstract: A method is provided for making a banana or plantain product comprising providing at least one unpeeled banana or plantain comprising banana or plantain peel and banana or plantain pulp, subjecting the at least one unpeeled banana or plantain to a heat treatment at a temperature and for a time sufficient to gelatinize starch present in the at least one unpeeled banana or plantain to form at least one heat treated unpeeled banana or plantain, and comminuting the at least one heat treated unpeeled banana or plantain to form a banana or plantain puree. A functional food ingredient is also provided comprising a banana or plantain puree including banana or plantain pulp and optionally banana or plantain peel. Foods containing banana or plantain puree or powder are provided, including crackers, snack bars, cereals, smoothies, and cookies.Type: GrantFiled: December 16, 2013Date of Patent: December 11, 2018Assignee: Dow Global Technologies LLCInventors: Shang-Tian Yang, Ehab Ammar, Christopher C. Stowers, Brandon A. Rodriguez
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Patent number: 9284580Abstract: This invention relates to compositions, systems, and methods for producing biofuels, such as butanol, and related compounds. More specifically, provided are methods of making recombinant microorganizms having non-naturally occurring metabolic pathways for the production of biofuels, and methods of producing biofuels using such organizms. Also provided are metabolically engineered microorganizms capable of producing butanol from a substrate.Type: GrantFiled: September 30, 2011Date of Patent: March 15, 2016Inventors: Shang-Tian Yang, Mingrui Yu
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Publication number: 20150366248Abstract: A method is provided for making a banana or plantain product comprising providing at least one unpeeled banana or plantain comprising banana or plantain peel and banana or plantain pulp, subjecting the at least one unpeeled banana or plantain to a heat treatment at a temperature and for a time sufficient to gelatinize starch present in the at least one unpeeled banana or plantain to form at least one heat treated unpeeled banana or plantain, and comminuting the at least one heat treated unpeeled banana or plantain to form a banana or plantain puree. A functional food ingredient is also provided comprising a banana or plantain puree including banana or plantain pulp and optionally banana or plantain peel.Type: ApplicationFiled: December 16, 2013Publication date: December 24, 2015Inventors: Shang-Tian Yang, Ehab Ammar, Christopher C. Stowers, Brandon A. Rodriguez
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Patent number: 8652564Abstract: Protein binding onto a polymeric surface is enhanced by treating the surface with an amine-bearing polymer like poly(ethylene imine). When used in ELISA, the treated surface improves the performance of the assay.Type: GrantFiled: May 7, 2007Date of Patent: February 18, 2014Assignee: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Yunling Bai
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Patent number: 8603806Abstract: The methods generally relate to three-dimensional culturing of cells with the steps of seeding a cell support structure in a device with at least one vessel for cell culture having a bottom, at least one wall and a cell support structure for three-dimensional cell culture. The cell support structure is inside the at least one vessel and the device is configured such that assays can be performed. Devices for performing cell culture and assays are also provided. It will be understood that the devices can have many different suitable configurations. In general, the devices are selected such that they can be used with suitable radiation based assays.Type: GrantFiled: November 2, 2006Date of Patent: December 10, 2013Assignee: The Ohio State Universtiy Research FoundationInventors: Shang-Tian Yang, Xudong Zhang, Yuan Wen
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Publication number: 20130323809Abstract: This invention relates to compositions, systems, and methods for producing biofuels, such as butanol, and related compounds. More specifically, provided are methods of making recombinant microorganisms having non-naturally occurring metabolic pathways for the production of biofuels, and methods of producing biofuels using such organisms. Also provided are metabolically engineered microorganisms capable of producing butanol from a substrate.Type: ApplicationFiled: September 30, 2011Publication date: December 5, 2013Applicant: THE OHIO STATE UNIVERSITYInventors: Shang-Tian Yang, Mingrui Yu
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Patent number: 8450093Abstract: Adaptive engineering of microorganisms to create mutants exhibiting high butanol tolerance and productivity. Mutant strains are obtained through the fermentation of parental strains in a fibrous bed bioreactor in the presence of butanol. Also provided are methods of producing butanol using mutant strains in ABE fermentation. Butanol production may be furthered by gas stripping and distillation. Also provided are mutant proteins for increasing butanol production in a microorganism.Type: GrantFiled: November 9, 2011Date of Patent: May 28, 2013Assignee: The Ohio State UniversityInventors: Shang-Tian Yang, Jingbo Zhao
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Patent number: 8357519Abstract: Methods are provided for producing esters. The methods comprise converting a fermentable carbon source to organic acids by fermentation with organic acid producing microorganisms, followed by catalytic esterification. The methods comprise integrated fermentation, extraction, and esterification reactions wherein the organic acids produced during fermentation are extracted into an extraction solvent and then directly reacted with an alcohol in the presence of a catalyst to form organic esters. Methods of producing esters are also provided wherein the organic acids produced during fermentation and extracted into the extraction solvent are stripped from the extraction solvent prior to being reacted with an alcohol in the presence of a catalyst to form organic esters.Type: GrantFiled: November 19, 2009Date of Patent: January 22, 2013Assignee: The Ohio State UniversityInventor: Shang-Tian Yang
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Patent number: 8075854Abstract: A microfluidic chip comprises a substrate and a channel or multiple channels in the substrate. Each channel includes a tortuous path section or multiple tortuous path sections. A receptor for the detection of an analyte can be immobilized in a tortuous path section, for example by adsorption. Different receptors can be immobilized in different tortuous path sections of each channel or in different channels for simultaneous detection of multiple analytes. The chip is especially useful for running immunoassays, particularly ELISA.Type: GrantFiled: November 8, 2007Date of Patent: December 13, 2011Inventors: Shang-Tian Yang, Yunling Bai, Wei-Cho Huang
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Publication number: 20110151529Abstract: A fermentation process for the production of organic acids is provided and includes, providing metabolically engineered mutant bacteria which have had one or both of ack and pta genes disrupted, adapting the mutant bacteria to increase their resistance to acids and to increase their growth rate by immobilizing the mutant bacteria while exposing the mutant bacteria to a fermentable substrate, and further exposing the adapted mutant bacteria to a fermentable substrate for a time sufficient to provide a final organic acid fermentation product concentration of greater than about 50 g/L.Type: ApplicationFiled: June 19, 2008Publication date: June 23, 2011Applicant: THE OHIO STATE UNIVERSITYInventor: Shang-Tian Yang
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Patent number: 7811796Abstract: A multilayer enzyme immobilization process is provided comprising adsorbing a polyethyleneimine (PEI) solution in a fibrous matrix, and adding an enzyme to the fibrous matrix, which comprises a plurality of fibrils. The process further comprises forming at least two layers of PEI-enzyme aggregates on the fibrils, and cross-linking the multilayer PEI-enzyme aggregates. The process can further comprise washing the fibrils containing the cross-linked PEI-enzyme aggregates with distilled water and acetic acid buffer subsequent to cross-linking. However, the PEI-containing matrix is not washed prior to the addition of enzyme. The enzyme can be ?-galactosidase and the fibrous matrix can be cotton cloth. The multilayer immobilized enzyme can be employed in a biocatalyst reactor for production of galacto-oligosaccharides from lactose and the hydrolysis of lactose to glucose and galactose.Type: GrantFiled: December 4, 2006Date of Patent: October 12, 2010Assignee: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Nedim Albayrak
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Publication number: 20100124773Abstract: Methods are provided for producing esters. The methods comprise converting a fermentable carbon source to organic acids by fermentation with organic acid producing microorganisms, followed by catalytic esterification. The methods comprise integrated fermentation, extraction, and esterification reactions wherein the organic acids produced during fermentation are extracted into an extraction solvent and then directly reacted with an alcohol in the presence of a catalyst to form organic esters. Methods of producing esters are also provided wherein the organic acids produced during fermentation and extracted into the extraction solvent are stripped from the extraction solvent prior to being reacted with an alcohol in the presence of a catalyst to form organic esters.Type: ApplicationFiled: November 19, 2009Publication date: May 20, 2010Applicant: THE OHIO STATE UNIVERSITYInventor: Shang-Tian Yang
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Publication number: 20090123336Abstract: A microfluidic chip comprises a substrate and a channel or multiple channels in the substrate. Each channel includes a tortuous path section or multiple tortuous path sections. A receptor for the detection of an analyte can be immobilized in a tortuous path section, for example by adsorption. Different receptors can be immobilized in different tortuous path sections of each channel or in different channels for simultaneous detection of multiple analytes. The chip is especially useful for running immunoassays, particularly ELISA.Type: ApplicationFiled: November 8, 2007Publication date: May 14, 2009Applicant: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Yunling Bai, Wei-Cho Huang
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Publication number: 20080248540Abstract: A method of producing butanol from carbohydrates is provided. A feedstock comprising a carbohydrate source is fermented in the presence of bacteria to produce butyric acid and hydrogen. The butyric acid is then hydrogenated in the presence of a catalyst to produce butanol.Type: ApplicationFiled: April 3, 2008Publication date: October 9, 2008Applicant: THE OHIO STATE UNIVERSITYInventor: Shang-Tian Yang
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Publication number: 20070264676Abstract: Protein binding onto a polymeric surface is enhanced by treating the surface with an amine-bearing polymer like poly(ethylene imine). When used in ELISA, the treated surface improves the performance of the assay.Type: ApplicationFiled: May 7, 2007Publication date: November 15, 2007Applicant: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Yunling Bai
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Publication number: 20070178586Abstract: Methods of culturing stem cells including growing fibroblast cells on a three-dimensional scaffold, perfusing the fibroblast cells with a cell culture medium to form fibroblast cell-conditioned cell culture medium, and growing the stem cells on a three-dimensional scaffold perfused with the fibroblast cell-conditioned cell culture medium are presented. Multi-stage bioreactors for growing stem cells, comprising a first fibrous bed bioreactor in fluid communication with a second fibrous bed bioreactor are also presented.Type: ApplicationFiled: November 9, 2006Publication date: August 2, 2007Applicant: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Anil Ouyang
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Publication number: 20070111289Abstract: A multilayer enzyme immobilization process is provided comprising adsorbing a polyethyleneimine (PEI) solution in a fibrous matrix, and adding an enzyme to the fibrous matrix, which comprises a plurality of fibrils. The process further comprises forming at least two layers of PEI-enzyme aggregates on the fibrils, and cross-linking the multilayer PEI-enzyme aggregates. The process can further comprise washing the fibrils containing the cross-linked PEI-enzyme aggregates with distilled water and acetic acid buffer subsequent to cross-linking. However, the PEI-containing matrix is not washed prior to the addition of enzyme. The enzyme can be ?-galactosidase and the fibrous matrix can be cotton cloth. The multilayer immobilized enzyme can be employed in a biocatalyst reactor for production of galacto-oligosaccharides from lactose and the hydrolysis of lactose to glucose and galactose.Type: ApplicationFiled: December 4, 2006Publication date: May 17, 2007Inventors: Shang-Tian Yang, Nedim Albayrak
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Publication number: 20070099294Abstract: The methods generally relate to three-dimensional culturing of cells with the steps of seeding a cell support structure in a device with at least one vessel for cell culture having a bottom, at least one wall and a cell support structure for three-dimensional cell culture. The cell support structure is inside the at least one vessel and the device is configured such that assays can be performed. Devices for performing cell culture and assays are also provided. It will be understood that the devices can have many different suitable configurations. In general, the devices are selected such that they can be used with suitable radiation based assays.Type: ApplicationFiled: November 2, 2006Publication date: May 3, 2007Applicant: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Xudong Zhang, Yuan Wen
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Patent number: 7166451Abstract: A multilayer enzyme immobilization process is provided comprising adsorbing a polyethyleneimine (PEI) solution in a fibrous matrix, and adding an enzyme to the fibrous matrix, which comprises a plurality of fibrils. The process further comprises forming at least two layers of PEI-enzyme aggregates on the fibrils, and cross-linking the multilayer PEI-enzyme aggregates. The process can further comprise washing the fibrils containing the cross-linked PEI-enzyme aggregates with distilled water and acetic acid buffer subsequent to cross-linking. However, the PEI-containing matrix is not washed prior to the addition of enzyme. The enzyme can be ?-galactosidase and the fibrous matrix can be cotton cloth. The multilayer immobilized enzyme can be employed in a biocatalyst reactor for production of galacto-oligosaccharides from lactose and the hydrolysis of lactose to glucose and galactose.Type: GrantFiled: February 24, 2004Date of Patent: January 23, 2007Assignee: The Ohio State UniversityInventors: Shang-Tian Yang, Nedim Albayrak
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Patent number: 6787340Abstract: The present invention includes a process for separating cells from a liquid media, a method of fermentation using such a separation, and an apparatus for conducting such a separation or for facilitating a cellular reaction. In broadest terms, the separation process of the present invention is a process for separating cells from a liquid containing cells. The process comprises the steps of: (a) bringing the liquid containing the cells into contact with one or more microbial polysaccharide and a fibrous material so as to adsorb the cells onto the fibrous material; and (b) separating the liquid from the fibrous material so as to remove the cells from the liquid. The process of the present invention may be used to remove cells from any liquid, but such liquids typically will be aqueous solutions, such as growth media, biological fluids, diagnostic samples, aqueous test samples, etc.Type: GrantFiled: October 21, 1999Date of Patent: September 7, 2004Assignee: The Ohio State UniversityInventor: Shang-Tian Yang