Patents by Inventor Shanta Modak
Shanta Modak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050048139Abstract: The present invention provides for compositions and methods that may offer protection from irritants as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions that lack conventional antibiotics or preservatives, wherein the antimicrobial benefit is created by essential oils (or their active ingredients), emollient solvents and, in some instances, anti-inflammatory agents.Type: ApplicationFiled: July 15, 2004Publication date: March 3, 2005Inventors: Shanta Modak, Trupti Gaonkar, Milind Shintre, Lauserpina Caraos
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Publication number: 20050019431Abstract: The present invention relates to compositions comprising quaternary ammonium compounds and essential oils or individual constituents thereof which exhibit enhanced antimicrobial effects. Such combinations may be comprised in lotions, gels, creams, soaps, etc. for application to skin or mucous membranes. The invention is based, at least in part, on the observation that synergistic antimicrobial effects are achieved with combinations of essential oils or individual constituents thereof and low concentrations of quaternary ammonium compounds.Type: ApplicationFiled: July 15, 2004Publication date: January 27, 2005Inventors: Shanta Modak, Milind Shintre, Trupti Gaonkar, Lauserpina Caraos
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Patent number: 6846846Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.Type: GrantFiled: October 23, 2001Date of Patent: January 25, 2005Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Trupti A. Gaonkar, Lester Sampath
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Patent number: 6843784Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.Type: GrantFiled: February 5, 2001Date of Patent: January 18, 2005Assignee: The Trustees Of Columbia University in the city of New YorkInventors: Shanta Modak, Lester Sampath
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Publication number: 20040247685Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.Type: ApplicationFiled: February 24, 2004Publication date: December 9, 2004Inventors: Shanta Modak, Trupti A. Gaonkar, Lauser Caraos, Lester Sampath
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Publication number: 20040219227Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.Type: ApplicationFiled: February 25, 2004Publication date: November 4, 2004Inventors: Shanta Modak, Trupti A. Gaonkar
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Publication number: 20040039349Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.Type: ApplicationFiled: August 25, 2003Publication date: February 26, 2004Inventors: Shanta Modak, Lester Sampath
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Patent number: 6626873Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.Type: GrantFiled: July 18, 2000Date of Patent: September 30, 2003Assignee: Trustees of Columbia UniversityInventors: Shanta Modak, Lester Sampath
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Publication number: 20030152644Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.Type: ApplicationFiled: October 23, 2001Publication date: August 14, 2003Inventors: Shanta Modak, Trupti A. Gaonkar, Lester Sampath
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Patent number: 6503952Abstract: An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.Type: GrantFiled: January 11, 2001Date of Patent: January 7, 2003Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Lester Sampath, Lauserpina A. Caraos
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Publication number: 20010016589Abstract: An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.Type: ApplicationFiled: January 11, 2001Publication date: August 23, 2001Inventors: Shanta Modak, Lester Sampath, Lauserpina Caraos
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Publication number: 20010010016Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.Type: ApplicationFiled: February 5, 2001Publication date: July 26, 2001Inventors: Shanta Modak, Lester Sampath
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Patent number: 6224579Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.Type: GrantFiled: March 31, 1999Date of Patent: May 1, 2001Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 6106505Abstract: The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.Type: GrantFiled: June 30, 1998Date of Patent: August 22, 2000Assignee: The Trustees of Columbia University of the City of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 6083208Abstract: The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers.Type: GrantFiled: April 17, 1998Date of Patent: July 4, 2000Assignee: The Trustees of Columbia University of the City of New YorkInventors: Shanta Modak, Sampath Lester
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Patent number: 5985931Abstract: The present invention relates to antimicrobial compositons comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 1 percent by weight of a quaternary ammonium compound, such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial deterents, soaps, creams rinses, and emulsions for use in the medical community as well as general public use.Type: GrantFiled: June 2, 1998Date of Patent: November 16, 1999Assignee: The Trustees of Columbia University in the city of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 5985918Abstract: The present invention relates to the use of organic salts of zinc in topical formulations. Such organic salts tend to be less water soluble and therefore less likely to result in systemic toxicity, even with chronic use. In preferred embodiments, the composition of the invention comprise zinc salicylate, which provides the antiinflammatory effect of salicylate, but wherein the zinc moiety counteracts toxic effects associated with salicylate.Type: GrantFiled: December 4, 1996Date of Patent: November 16, 1999Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Lester Sampath, Lauserpina Caraos
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Patent number: 5772640Abstract: The present invention relates to polymeric medical articles contained the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are contained in either hydrophilic or hydrophobic polymers.Type: GrantFiled: January 5, 1996Date of Patent: June 30, 1998Assignee: The Trustees of Columbia University of the City of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 5705532Abstract: The present invention relates to antimicrobial compositions comprising (i) less than or equal to two percent by weight chlorhexidine or chlorhexidine salt; (ii) less than or equal to 0.1 percent by weight of a quaternary ammonium compound such as benzalkonium chloride; and (iii) less than or equal to two percent by weight of parachlorometaxylenol. The antimicrobial compositions of the invention may be utilized in antimicrobial detergents, soaps, creams, rinses, and emulsions for use in the medical community as well as general public use.Type: GrantFiled: November 13, 1995Date of Patent: January 6, 1998Assignee: The Trustees of Columbia University of The City of New YorkInventors: Shanta Modak, Lester Sampath
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Patent number: 5567495Abstract: The present invention provides for medical devices which are antiinfective as a result of antiinfective agents impregnated onto their surfaces and/or antiinfective activity incorporated into their access sites. It is based, at least in part, on the discovery that certain combinations of antimicrobial agents and solvents change the surface characteristics of polymeric medical devices, thereby facilitating the retention of antimicrobial agents. It is further based on the discovery that the incorporation of antiinfective polymeric inserts into the access site of a medical device provides substantially improved antiinfective activity.Type: GrantFiled: July 11, 1994Date of Patent: October 22, 1996Assignee: The Trustees of Columbia University In The City of New YorkInventors: Shanta Modak, Lester Sampath