Patents by Inventor Shaoling Li

Shaoling Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination dosage form of a mu opioid receptor antagonist and an opioid agent
    Patent number: 11452723
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: September 27, 2022
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • SOLID FORMS OF {6-[(2-AMINO-3-CHLOROPYRIDIN-4-YL)SULFANYL]-3-[(3S,4S)-4-AMINO-3-METHYL-2-OXA-8-AZASPIRO[4.5]DECAN-8-YL]-5-METHYLPYRAZIN-2-YL}METHANOL, A SHP2 INHIBITOR
    Publication number: 20220298159
    Abstract: The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: November 29, 2021
    Publication date: September 22, 2022
    Applicant: Revolution Medicines, Inc.
    Inventors: Shaoling LI, Steven G. BALLMER
  • Solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl} methanol, a SHP2 inhibitor
    Patent number: 11220501
    Abstract: The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: January 11, 2022
    Assignee: Revolution Medicines, Inc.
    Inventors: Shaoling Li, Steven G. Ballmer
  • SOLID FORMS OF {6-[(2-AMINO-3-CHLOROPYRIDIN-4-YL)SULFANYL]-3-[(3S,4S)-4-AMINO-3-METHYL-2-OXA-8-AZASPIRO[4.5]DECAN-8-YL]-5-METHYLPYRAZIN-2-YL}METHANOL, AN SHP2 INHIBITOR
    Publication number: 20210253574
    Abstract: The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 19, 2021
    Inventors: Shaoling LI, Steven G. BALLMER
  • COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
    Publication number: 20210161884
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 3, 2021
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20210113541
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 22, 2021
    Inventors: Subramanian S. VENKATRAMAN, Shaoling LI, Robert M. GALE, Jane STEPIC, William W. VAN OSDOL
  • Combination dosage form of a mu opioid receptor antagonist and an opioid agent
    Patent number: 10946009
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20200289488
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventors: Subramanian VENKATRAMAN, Shaoling LI, Robert M. GALE, Jane STEPIC, William W. VAN OSDOL
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20200054619
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: October 24, 2019
    Publication date: February 20, 2020
    Inventors: Subramanian VENKATRAMAN, Shaoling LI, Robert M. GALE, Jane STEPIC, William W. VAN OSDOL
  • COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
    Publication number: 20190321350
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 24, 2019
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • Combination dosage form of a mu opioid receptor antagonist and an opioid agent
    Patent number: 10369142
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: August 6, 2019
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • Transdermal Administration Of Fentanyl And Analogs Thereof
    Publication number: 20190167655
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 6, 2019
    Inventors: Subramanian VENKATRAMAN, Shaoling Li, Robert M. Gale, Jane Stepic, William W. Van Osdol
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20180098979
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: December 8, 2017
    Publication date: April 12, 2018
    Inventors: SUBRAMANIAN S. VENKATRAMAN, SHAOLING LI, ROBERT M. GALE, JANE STEPIC, WILLIAM W. VAN OSDOL
  • COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
    Publication number: 20180050028
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Application
    Filed: October 31, 2017
    Publication date: February 22, 2018
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20160331740
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: July 25, 2016
    Publication date: November 17, 2016
    Inventors: SUBRAMANIAN S. VENKATRAMAN, SHAOLING LI, ROBERT M. GALE, JANE STEPIC, WILLIAM W. VAN OSDOL
  • COMBINATION DOSAGE FORM OF A MU OPIOID RECEPTOR ANTAGONIST AND AN OPIOID AGENT
    Publication number: 20160287573
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles
    Patent number: 9066870
    Abstract: The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: June 30, 2015
    Assignees: Nanjing University, Nanjing Effect Pharm Drug Development Corporation
    Inventors: Yiqiao Hu, Jinhui Wu, Dawei Ding, Guangming Gong, Xiaolei Tang, Chunhui Tong, Yan Zhu, Shaoling Li
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20140271799
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: June 2, 2014
    Publication date: September 18, 2014
    Applicant: ALZA Corporation
    Inventors: SUBRAMANIAN S. VENKATRAMAN, SHAOLING LI, ROBERT M. GALE, JANE STEPIC, WILLIAM W. VAN OSDOL
  • TRANSDERMAL ADMINISTRATION OF FENTANYL AND ANALOGS THEREOF
    Publication number: 20140030316
    Abstract: A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 30, 2014
    Applicant: ALZA Corporation
    Inventors: Subramanian S. Venkatraman, Shaoling Li, Robert M. Gale, Jane Stepic, William W. Van Osdol
  • METHODS FOR DRUG DELIVERY COMPRISING UNFOLDING AND FOLDING PROTEINS AND PEPTIDE NANOPARTICLES
    Publication number: 20110059181
    Abstract: The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.
    Type: Application
    Filed: August 6, 2010
    Publication date: March 10, 2011
    Applicant: NanoPax Pharma, LLC
    Inventors: Yiqiao Hu, Jinhui Wu, Dawei Ding, Guangming Gong, Xiaolei Tang, Chunhui Tong, Yan Zhu, Shaoling Li